SidaSubSaharaV1, Ncbi, Merge, bibRecord, 000928

Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy.

Identifieur interne : 000928 ( Ncbi/Merge ); précédent : 000927; suivant : 000929

Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy.

Auteurs : Eugène Messou [France] ; Xavier Anglaret ; Julien Duvignac ; Eric Konan-N'Dri ; Eric Komena ; Joachim Gnokoro ; Sophie Karcher ; Anthony Tanoh ; Thérèse N'Dri-Yoman ; Catherine Seyler

Source :

AIDS (London, England) [ 1473-5571 ] ; 2010.

RBID : pubmed:19935382

Descripteurs français

KwdFr :
- Agents antiVIH (effets indésirables), Agents antiVIH (usage thérapeutique), Charge virale, Complications de la grossesse et maladies infectieuses (traitement médicamenteux), Complications de la grossesse et maladies infectieuses (virologie), Côte d'Ivoire (épidémiologie), Femelle, Grossesse, Humains, Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Mâle, Substitution de médicament (), Thérapie antirétrovirale hautement active (effets indésirables), Tuberculose (immunologie), Tuberculose (traitement médicamenteux), Tuberculose (virologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
MESH :
- effets indésirables : Agents antiVIH, Thérapie antirétrovirale hautement active.
- immunologie : Infections à VIH, Tuberculose, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- traitement médicamenteux : Complications de la grossesse et maladies infectieuses, Infections à VIH, Tuberculose.
- usage thérapeutique : Agents antiVIH.
- virologie : Complications de la grossesse et maladies infectieuses, Infections à VIH, Tuberculose.
- épidémiologie : Côte d'Ivoire.
- Charge virale, Femelle, Grossesse, Humains, Mâle, Substitution de médicament.

English descriptors

KwdEn :
- Anti-HIV Agents (adverse effects), Anti-HIV Agents (therapeutic use), Antiretroviral Therapy, Highly Active (adverse effects), Cote d'Ivoire (epidemiology), Drug Substitution (statistics & numerical data), Female, HIV Infections (drug therapy), HIV Infections (immunology), HIV Infections (virology), HIV-1 (immunology), Humans, Male, Pregnancy, Pregnancy Complications, Infectious (drug therapy), Pregnancy Complications, Infectious (virology), Tuberculosis (drug therapy), Tuberculosis (immunology), Tuberculosis (virology), Viral Load.
MESH :
- chemical , adverse effects : Anti-HIV Agents.
- chemical , therapeutic use : Anti-HIV Agents.
- geographic , epidemiology : Cote d'Ivoire.
- adverse effects : Antiretroviral Therapy, Highly Active.
- drug therapy : HIV Infections, Pregnancy Complications, Infectious, Tuberculosis.
- immunology : HIV Infections, HIV-1, Tuberculosis.
- statistics & numerical data : Drug Substitution.
- virology : HIV Infections, Pregnancy Complications, Infectious, Tuberculosis.
- Female, Humans, Male, Pregnancy, Viral Load.

Abstract

To determine the rates and causes of first antiretroviral treatment changes in HIV-infected adults in Côte d'Ivoire.

DOI: 10.1097/QAD.0b013e32832ec1c3
PubMed: 19935382

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000469
to stream PubMed, to step Curation: 000469
to stream PubMed, to step Checkpoint: 000469

Links to Exploration step

pubmed:19935382

Le document en format XML

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<term>Antiretroviral Therapy, Highly Active (adverse effects)</term>
<term>Cote d'Ivoire (epidemiology)</term>
<term>Drug Substitution (statistics & numerical data)</term>
<term>Female</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (immunology)</term>
<term>Humans</term>
<term>Male</term>
<term>Pregnancy</term>
<term>Pregnancy Complications, Infectious (drug therapy)</term>
<term>Pregnancy Complications, Infectious (virology)</term>
<term>Tuberculosis (drug therapy)</term>
<term>Tuberculosis (immunology)</term>
<term>Tuberculosis (virology)</term>
<term>Viral Load</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Agents antiVIH (effets indésirables)</term>
<term>Agents antiVIH (usage thérapeutique)</term>
<term>Charge virale</term>
<term>Complications de la grossesse et maladies infectieuses (traitement médicamenteux)</term>
<term>Complications de la grossesse et maladies infectieuses (virologie)</term>
<term>Côte d'Ivoire (épidémiologie)</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (virologie)</term>
<term>Mâle</term>
<term>Substitution de médicament ()</term>
<term>Thérapie antirétrovirale hautement active (effets indésirables)</term>
<term>Tuberculose (immunologie)</term>
<term>Tuberculose (traitement médicamenteux)</term>
<term>Tuberculose (virologie)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Cote d'Ivoire</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Antiretroviral Therapy, Highly Active</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
<term>Pregnancy Complications, Infectious</term>
<term>Tuberculosis</term>
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<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Agents antiVIH</term>
<term>Thérapie antirétrovirale hautement active</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à VIH</term>
<term>Tuberculose</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term>
<term>HIV-1</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Substitution</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Complications de la grossesse et maladies infectieuses</term>
<term>Infections à VIH</term>
<term>Tuberculose</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Complications de la grossesse et maladies infectieuses</term>
<term>Infections à VIH</term>
<term>Tuberculose</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
<term>Pregnancy Complications, Infectious</term>
<term>Tuberculosis</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Côte d'Ivoire</term>
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<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Pregnancy</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Charge virale</term>
<term>Femelle</term>
<term>Grossesse</term>
<term>Humains</term>
<term>Mâle</term>
<term>Substitution de médicament</term>
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<front><div type="abstract" xml:lang="en">To determine the rates and causes of first antiretroviral treatment changes in HIV-infected adults in Côte d'Ivoire.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19935382</PMID>
<DateCreated><Year>2009</Year>
<Month>12</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2010</Year>
<Month>12</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5571</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>1</Issue>
<PubDate><Year>2010</Year>
<Month>Jan</Month>
<Day>02</Day>
</PubDate>
</JournalIssue>
<Title>AIDS (London, England)</Title>
<ISOAbbreviation>AIDS</ISOAbbreviation>
</Journal>
<ArticleTitle>Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy.</ArticleTitle>
<Pagination><MedlinePgn>93-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/QAD.0b013e32832ec1c3</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the rates and causes of first antiretroviral treatment changes in HIV-infected adults in Côte d'Ivoire.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We evaluated adults who initiated antiretroviral treatment in an outpatient clinic in Abidjan. We recorded baseline and follow-up data, including drug prescriptions and reasons for changing to alternative first-line regimens (drug substitution for any reason but failure) or second-line regimens (switch for failure).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Two thousand and twelve HIV-infected adults (73% women) initiated antiretroviral treatment. At baseline, 9% of all patients were on treatment for tuberculosis and 3% of women were pregnant. First-line antiretroviral treatment consisted of two nucleoside reverse transcriptase inhibitors (58% stavudine-lamivudine, 42% zidovudine-lamivudine) and efavirenz (63%), nevirapine (32%) or indinavir (5%). Median follow-up time was 16.9 months. During this time, 205 (10%) patients died and 261 (13%) were lost to follow-up. Overall, the rate of treatment modifications was 20.7/100 patient-years. The most common modifications were drug substitutions for intolerance (12.4/100 patient-years), pregnancy (4.5/100 patient-years) and tuberculosis (2.5/100 patient-years). The rates of intolerance-related substitutions were 17.9/100 patient-years for stavudine, 6.3/100 patient-years for nevirapine, 3.9/100 patient-years for zidovudine and 0.1/100 patient-years for efavirenz. Twenty percent of efavirenz substitutions resulted from pregnancy and 18% of nevirapine substitutions were related to tuberculosis treatment.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">During the first months following antiretroviral treatment initiation, a third of all treatment changes occurred for reasons other than intolerance to the drug or treatment failure. In Africa, drug forecasting is crucial to ensuring the success of HIV treatment programmes. Drugs that do not require interruptions during pregnancy or tuberculosis treatment should be made more readily available as first-line drugs in sub-Saharan Africa.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Messou</LastName>
<ForeName>Eugène</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>INSERM U897, Université Victor Segalen Bordeaux 2, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anglaret</LastName>
<ForeName>Xavier</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Duvignac</LastName>
<ForeName>Julien</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Konan-N'dri</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Komena</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gnokoro</LastName>
<ForeName>Joachim</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Karcher</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Tanoh</LastName>
<ForeName>Anthony</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>N'dri-Yoman</LastName>
<ForeName>Thérèse</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><LastName>Seyler</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>R01 AI058736</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
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</PublicationTypeList>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>AIDS</MedlineTA>
<NlmUniqueID>8710219</NlmUniqueID>
<ISSNLinking>0269-9370</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CitationSubset>X</CitationSubset>
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<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023241" MajorTopicYN="N">Antiretroviral Therapy, Highly Active</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007560" MajorTopicYN="N" Type="Geographic">Cote d'Ivoire</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D057915" MajorTopicYN="Y">Drug Substitution</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015497" MajorTopicYN="Y">HIV-1</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011251" MajorTopicYN="N">Pregnancy Complications, Infectious</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014376" MajorTopicYN="N">Tuberculosis</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
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<OtherID Source="NLM">NIHMS517976</OtherID>
<OtherID Source="NLM">PMC3936254</OtherID>
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<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year>
<Month>11</Month>
<Day>26</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2009</Year>
<Month>11</Month>
<Day>26</Day>
<Hour>6</Hour>
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</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2010</Year>
<Month>12</Month>
<Day>29</Day>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">19935382</ArticleId>
<ArticleId IdType="doi">10.1097/QAD.0b013e32832ec1c3</ArticleId>
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<affiliations><list><country><li>France</li>
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<region><li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
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<settlement><li>Bordeaux</li>
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</list>
<tree><noCountry><name sortKey="Anglaret, Xavier" sort="Anglaret, Xavier" uniqKey="Anglaret X" first="Xavier" last="Anglaret">Xavier Anglaret</name>
<name sortKey="Duvignac, Julien" sort="Duvignac, Julien" uniqKey="Duvignac J" first="Julien" last="Duvignac">Julien Duvignac</name>
<name sortKey="Gnokoro, Joachim" sort="Gnokoro, Joachim" uniqKey="Gnokoro J" first="Joachim" last="Gnokoro">Joachim Gnokoro</name>
<name sortKey="Karcher, Sophie" sort="Karcher, Sophie" uniqKey="Karcher S" first="Sophie" last="Karcher">Sophie Karcher</name>
<name sortKey="Komena, Eric" sort="Komena, Eric" uniqKey="Komena E" first="Eric" last="Komena">Eric Komena</name>
<name sortKey="Konan N Dri, Eric" sort="Konan N Dri, Eric" uniqKey="Konan N Dri E" first="Eric" last="Konan-N'Dri">Eric Konan-N'Dri</name>
<name sortKey="N Dri Yoman, Therese" sort="N Dri Yoman, Therese" uniqKey="N Dri Yoman T" first="Thérèse" last="N'Dri-Yoman">Thérèse N'Dri-Yoman</name>
<name sortKey="Seyler, Catherine" sort="Seyler, Catherine" uniqKey="Seyler C" first="Catherine" last="Seyler">Catherine Seyler</name>
<name sortKey="Tanoh, Anthony" sort="Tanoh, Anthony" uniqKey="Tanoh A" first="Anthony" last="Tanoh">Anthony Tanoh</name>
</noCountry>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Messou, Eugene" sort="Messou, Eugene" uniqKey="Messou E" first="Eugène" last="Messou">Eugène Messou</name>
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	Le SIDA en Afrique subsaharienne (serveur d'exploration)
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy.

Antiretroviral treatment changes in adults from Côte d'Ivoire: the roles of tuberculosis and pregnancy.

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