SidaSubSaharaV1, Ncbi, Merge, bibRecord, 000929

Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children.

Identifieur interne : 000929 ( Ncbi/Merge ); précédent : 000928; suivant : 000930

Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children.

Auteurs : Marcel Yotebieng [États-Unis] ; Annelies Van Rie ; Harry Moultrie ; Tammy Meyers

Source :

AIDS (London, England) [ 1473-5571 ] ; 2010.

RBID : pubmed:19940744

Descripteurs français

KwdFr :
- Adolescent, Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Indice de masse corporelle, Infections à VIH (), Infections à VIH (mortalité), Infections à VIH (traitement médicamenteux), Mâle, Nourrisson, Numération des lymphocytes CD4, Poids du corps (), Prise de poids (), République d'Afrique du Sud (épidémiologie), Taille (), Thérapie antirétrovirale hautement active, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
MESH :
- mortalité : Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- épidémiologie : République d'Afrique du Sud.
- Adolescent, Charge virale, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Indice de masse corporelle, Infections à VIH, Mâle, Nourrisson, Numération des lymphocytes CD4, Poids du corps, Prise de poids, Taille, Thérapie antirétrovirale hautement active, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
Wicri :
- geographic : Afrique du Sud.

English descriptors

KwdEn :
- Adolescent, Antiretroviral Therapy, Highly Active, Body Height (drug effects), Body Mass Index, Body Weight (drug effects), CD4 Lymphocyte Count, Child, Child, Preschool, Female, HIV Infections (complications), HIV Infections (drug therapy), HIV Infections (mortality), HIV-1, Humans, Infant, Male, South Africa (epidemiology), Viral Load, Weight Gain (drug effects).
MESH :
- geographic , epidemiology : South Africa.
- complications : HIV Infections.
- drug effects : Body Height, Body Weight, Weight Gain.
- drug therapy : HIV Infections.
- mortality : HIV Infections.
- Adolescent, Antiretroviral Therapy, Highly Active, Body Mass Index, CD4 Lymphocyte Count, Child, Child, Preschool, Female, HIV-1, Humans, Infant, Male, Viral Load.

Abstract

Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4%) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses.

DOI: 10.1097/QAD.0b013e328332d5ca
PubMed: 19940744

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000319
to stream PubMed, to step Curation: 000319
to stream PubMed, to step Checkpoint: 000319

Links to Exploration step

pubmed:19940744

Le document en format XML

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<term>Antiretroviral Therapy, Highly Active</term>
<term>Body Height (drug effects)</term>
<term>Body Mass Index</term>
<term>Body Weight (drug effects)</term>
<term>CD4 Lymphocyte Count</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>HIV Infections (complications)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (mortality)</term>
<term>HIV-1</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>South Africa (epidemiology)</term>
<term>Viral Load</term>
<term>Weight Gain (drug effects)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Charge virale</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Infections à VIH ()</term>
<term>Infections à VIH (mortalité)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Numération des lymphocytes CD4</term>
<term>Poids du corps ()</term>
<term>Prise de poids ()</term>
<term>République d'Afrique du Sud (épidémiologie)</term>
<term>Taille ()</term>
<term>Thérapie antirétrovirale hautement active</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
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<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>South Africa</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Infections</term>
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<term>Body Weight</term>
<term>Weight Gain</term>
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<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à VIH</term>
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<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Antiretroviral Therapy, Highly Active</term>
<term>Body Mass Index</term>
<term>CD4 Lymphocyte Count</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>HIV-1</term>
<term>Humans</term>
<term>Infant</term>
<term>Male</term>
<term>Viral Load</term>
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<term>Charge virale</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice de masse corporelle</term>
<term>Infections à VIH</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Numération des lymphocytes CD4</term>
<term>Poids du corps</term>
<term>Prise de poids</term>
<term>Taille</term>
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<front><div type="abstract" xml:lang="en">Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4%) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19940744</PMID>
<DateCreated><Year>2009</Year>
<Month>12</Month>
<Day>02</Day>
</DateCreated>
<DateCompleted><Year>2010</Year>
<Month>12</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>10</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5571</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>24</Volume>
<Issue>1</Issue>
<PubDate><Year>2010</Year>
<Month>Jan</Month>
<Day>02</Day>
</PubDate>
</JournalIssue>
<Title>AIDS (London, England)</Title>
<ISOAbbreviation>AIDS</ISOAbbreviation>
</Journal>
<ArticleTitle>Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children.</ArticleTitle>
<Pagination><MedlinePgn>139-46</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/QAD.0b013e328332d5ca</ELocationID>
<Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4 percentage (CD4%) in children initiating ART, and to assess the association between lower percentiles and subsequent ART responses.</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Cohort of 1394 HIV-infected children initiating ART between April 2004 and March 2008, Johannesburg, South Africa</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The generalized additive model for location, scale, and shape was used to construct percentile curves for 6-month gain in weight, height, CD4 cell count, and CD4%. Cox proportional models were used to assess the association between lower percentiles of each distribution and death, virological suppression, and treatment failure between 6 to 36 months post-ART initiation.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Lower percentiles for gain in weight, CD4, and CD4% count after 6 months of ART, but not height, were associated with poor subsequent treatment outcomes independent of baseline characteristics, with increasing strength of association as percentiles decreased. Age-specific 6-month post-ART weight gain in our cohort was substantially higher compared with 6-month weight gain in non-HIV-infected American children of the Fels Institute cohort and the attained weight-for-age at 6 months post-ART plotted on WHO weight-for-age growth charts were not associated with subsequent treatment outcomes.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Gain in CD4% in the first 6 months of ART was the best predictor of poor subsequent ART outcomes. In areas with limited access to CD4%, weight gain post-ART using our newly developed reference distributions for HIV-infected children on ART is a good alternative to CD4%, and clearly superior to the commonly used 'Road-to-Health' weight-for-age charts.</AbstractText>
</Abstract>
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<ForeName>Marcel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. yotebieng@unc.edu</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Van Rie</LastName>
<ForeName>Annelies</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Moultrie</LastName>
<ForeName>Harry</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Meyers</LastName>
<ForeName>Tammy</ForeName>
<Initials>T</Initials>
</Author>
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<Acronym>TW</Acronym>
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<Acronym>TW</Acronym>
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<CitationSubset>IM</CitationSubset>
<CitationSubset>X</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D023241" MajorTopicYN="N">Antiretroviral Therapy, Highly Active</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001827" MajorTopicYN="N">Body Height</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015992" MajorTopicYN="N">Body Mass Index</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001835" MajorTopicYN="N">Body Weight</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015497" MajorTopicYN="Y">HIV-1</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013019" MajorTopicYN="N" Type="Geographic">South Africa</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015430" MajorTopicYN="N">Weight Gain</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
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<orgName><li>Université de Caroline du Nord à Chapel Hill</li>
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<tree><noCountry><name sortKey="Meyers, Tammy" sort="Meyers, Tammy" uniqKey="Meyers T" first="Tammy" last="Meyers">Tammy Meyers</name>
<name sortKey="Moultrie, Harry" sort="Moultrie, Harry" uniqKey="Moultrie H" first="Harry" last="Moultrie">Harry Moultrie</name>
<name sortKey="Van Rie, Annelies" sort="Van Rie, Annelies" uniqKey="Van Rie A" first="Annelies" last="Van Rie">Annelies Van Rie</name>
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<country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Yotebieng, Marcel" sort="Yotebieng, Marcel" uniqKey="Yotebieng M" first="Marcel" last="Yotebieng">Marcel Yotebieng</name>
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	Le SIDA en Afrique subsaharienne (serveur d'exploration)
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Le SIDA en Afrique subsaharienne (serveur d'exploration)

Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children.

Six-month gain in weight, height, and CD4 predict subsequent antiretroviral treatment responses in HIV-infected South African children.

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