The association of anti-phospholipid antibodies with parity in placental malaria
Identifieur interne : 000044 ( PascalFrancis/Curation ); précédent : 000043; suivant : 000045The association of anti-phospholipid antibodies with parity in placental malaria
Auteurs : S. Owens [Gambie, Royaume-Uni] ; L. W. Chamley [Nouvelle-Zélande] ; J. Ordi [Espagne] ; B. J. Brabin [Royaume-Uni, Pays-Bas] ; P. M. Johnson [Royaume-Uni]Source :
- Clinical and experimental immunology : (Print) [ 0009-9104 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β2 glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.
pA |
|
---|
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000101
Links to Exploration step
Pascal:06-0007882Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The association of anti-phospholipid antibodies with parity in placental malaria</title>
<author><name sortKey="Owens, S" sort="Owens, S" uniqKey="Owens S" first="S." last="Owens">S. Owens</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>MRC Laboratories, Atlantic Road</s1>
<s2>Fajara</s2>
<s3>GMB</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Gambie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Chamley, L W" sort="Chamley, L W" uniqKey="Chamley L" first="L. W." last="Chamley">L. W. Chamley</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
</affiliation>
</author>
<author><name sortKey="Ordi, J" sort="Ordi, J" uniqKey="Ordi J" first="J." last="Ordi">J. Ordi</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department d'Anatomia Patològica, Universitat de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B. J." last="Brabin">B. J. Brabin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam</s1>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Johnson, P M" sort="Johnson, P M" uniqKey="Johnson P" first="P. M." last="Johnson">P. M. Johnson</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Immunology, University of Liverpool</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0007882</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 06-0007882 INIST</idno>
<idno type="RBID">Pascal:06-0007882</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000101</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000044</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The association of anti-phospholipid antibodies with parity in placental malaria</title>
<author><name sortKey="Owens, S" sort="Owens, S" uniqKey="Owens S" first="S." last="Owens">S. Owens</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>MRC Laboratories, Atlantic Road</s1>
<s2>Fajara</s2>
<s3>GMB</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Gambie</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
<author><name sortKey="Chamley, L W" sort="Chamley, L W" uniqKey="Chamley L" first="L. W." last="Chamley">L. W. Chamley</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
</affiliation>
</author>
<author><name sortKey="Ordi, J" sort="Ordi, J" uniqKey="Ordi J" first="J." last="Ordi">J. Ordi</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department d'Anatomia Patològica, Universitat de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
</affiliation>
</author>
<author><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B. J." last="Brabin">B. J. Brabin</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam</s1>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
</affiliation>
</author>
<author><name sortKey="Johnson, P M" sort="Johnson, P M" uniqKey="Johnson P" first="P. M." last="Johnson">P. M. Johnson</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Immunology, University of Liverpool</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical and experimental immunology : (Print)</title>
<title level="j" type="abbreviated">Clin. exp. immunol. : (Print)</title>
<idno type="ISSN">0009-9104</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical and experimental immunology : (Print)</title>
<title level="j" type="abbreviated">Clin. exp. immunol. : (Print)</title>
<idno type="ISSN">0009-9104</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term>
<term>Diphosphatidylglycerol</term>
<term>Malaria</term>
<term>Parity</term>
<term>Phospholipid</term>
<term>Placenta</term>
<term>Pregnancy</term>
<term>β2 acid-Glycoprotein</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Paludisme</term>
<term>Phospholipide</term>
<term>Anticorps</term>
<term>Parité</term>
<term>Placenta</term>
<term>Glycoprotéine β2</term>
<term>Diphosphatidylglycérol</term>
<term>Gestation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β<sub>2</sub>
glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0009-9104</s0>
</fA01>
<fA02 i1="01"><s0>CEXIAL</s0>
</fA02>
<fA03 i2="1"><s0>Clin. exp. immunol. : (Print)</s0>
</fA03>
<fA05><s2>142</s2>
</fA05>
<fA06><s2>3</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>The association of anti-phospholipid antibodies with parity in placental malaria</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>OWENS (S.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>CHAMLEY (L. W.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>ORDI (J.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>BRABIN (B. J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>JOHNSON (P. M.)</s1>
</fA11>
<fA14 i1="01"><s1>MRC Laboratories, Atlantic Road</s1>
<s2>Fajara</s2>
<s3>GMB</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland</s1>
<s2>Auckland</s2>
<s3>NZL</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department d'Anatomia Patològica, Universitat de Barcelona</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam</s1>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Division of Immunology, University of Liverpool</s1>
<s2>Liverpool</s2>
<s3>GBR</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>512-518</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>12690</s2>
<s5>354000135196170150</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2006 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>28 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>06-0007882</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Clinical and experimental immunology : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β<sub>2</sub>
glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A06</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Paludisme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Malaria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Paludismo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Phospholipide</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Phospholipid</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Fosfolípido</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Anticorps</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Antibody</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Anticuerpo</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Parité</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Parity</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Paridad</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Placenta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Placenta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Placenta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Glycoprotéine β2</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>β2 acid-Glycoprotein</s0>
<s5>08</s5>
<s6>«β2 acid»-Glycoprotein</s6>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Glicoproteína β2</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Diphosphatidylglycérol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Diphosphatidylglycerol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Difosfatidilglicerol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Gestation</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Pregnancy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Gestación</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Protozoose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Protozoal disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Protozoosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Parasitose</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Parasitosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Parasitosis</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Immunologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Immunology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Inmunología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Annexe embryonnaire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Fetal membrane</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Membrana fetal</s0>
<s5>39</s5>
</fC07>
<fN21><s1>002</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/PascalFrancis/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000044 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000044 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= SidaGhanaV1 |flux= PascalFrancis |étape= Curation |type= RBID |clé= Pascal:06-0007882 |texte= The association of anti-phospholipid antibodies with parity in placental malaria }}
This area was generated with Dilib version V0.6.31. |