SidaGhanaV1, PascalFrancis, Corpus, bibRecord, 000101

The association of anti-phospholipid antibodies with parity in placental malaria

Identifieur interne : 000101 ( PascalFrancis/Corpus ); précédent : 000100; suivant : 000102

The association of anti-phospholipid antibodies with parity in placental malaria

Auteurs : S. Owens ; L. W. Chamley ; J. Ordi ; B. J. Brabin ; P. M. Johnson

Source :

Clinical and experimental immunology : (Print) [ 0009-9104 ] ; 2005.

RBID : Pascal:06-0007882

Descripteurs français

Pascal (Inist)
- Paludisme, Phospholipide, Anticorps, Parité, Placenta, Glycoprotéine β2, Diphosphatidylglycérol, Gestation.

English descriptors

KwdEn :
- Antibody, Diphosphatidylglycerol, Malaria, Parity, Phospholipid, Placenta, Pregnancy, β2 acid-Glycoprotein.

Abstract

Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β₂ glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`02`			`@1 Child and Reproductive Health Group, Liverpool School of Tropical Medicine @2 Liverpool @3 GBR @Z 1 aut. @Z 4 aut.`
A14	`03`			`@1 Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland @2 Auckland @3 NZL @Z 2 aut.`
A14	`04`			`@1 Department d'Anatomia Patològica, Universitat de Barcelona @2 Barcelona @3 ESP @Z 3 aut.`
A14	`05`			`@1 Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam @3 NLD @Z 4 aut.`
A14	`06`			`@1 Division of Immunology, University of Liverpool @2 Liverpool @3 GBR @Z 5 aut.`
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C01	`01`		`ENG`	@0 Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β₂ glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.
C02	`01`	`X`		`@0 002B06`
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C03	`01`	`X`	`SPA`	`@0 Paludismo @5 01`
C03	`02`	`X`	`FRE`	`@0 Phospholipide @5 02`
C03	`02`	`X`	`ENG`	`@0 Phospholipid @5 02`
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C03	`03`	`X`	`SPA`	`@0 Anticuerpo @5 03`
C03	`04`	`X`	`FRE`	`@0 Parité @5 05`
C03	`04`	`X`	`ENG`	`@0 Parity @5 05`
C03	`04`	`X`	`SPA`	`@0 Paridad @5 05`
C03	`05`	`X`	`FRE`	`@0 Placenta @5 06`
C03	`05`	`X`	`ENG`	`@0 Placenta @5 06`
C03	`05`	`X`	`SPA`	`@0 Placenta @5 06`
C03	`06`	`X`	`FRE`	`@0 Glycoprotéine β2 @5 08`
C03	`06`	`X`	`ENG`	`@0 β2 acid-Glycoprotein @5 08 @6 «β2 acid»-Glycoprotein`
C03	`06`	`X`	`SPA`	`@0 Glicoproteína β2 @5 08`
C03	`07`	`X`	`FRE`	`@0 Diphosphatidylglycérol @5 09`
C03	`07`	`X`	`ENG`	`@0 Diphosphatidylglycerol @5 09`
C03	`07`	`X`	`SPA`	`@0 Difosfatidilglicerol @5 09`
C03	`08`	`X`	`FRE`	`@0 Gestation @5 11`
C03	`08`	`X`	`ENG`	`@0 Pregnancy @5 11`
C03	`08`	`X`	`SPA`	`@0 Gestación @5 11`
C07	`01`	`X`	`FRE`	`@0 Protozoose`
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C07	`05`	`X`	`ENG`	`@0 Immunopathology @5 38`
C07	`05`	`X`	`SPA`	`@0 Inmunopatología @5 38`
C07	`06`	`X`	`FRE`	`@0 Annexe embryonnaire @5 39`
C07	`06`	`X`	`ENG`	`@0 Fetal membrane @5 39`
C07	`06`	`X`	`SPA`	`@0 Membrana fetal @5 39`
N21				`@1 002`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 06-0007882 INIST
ET :	The association of anti-phospholipid antibodies with parity in placental malaria
AU :	OWENS (S.); CHAMLEY (L. W.); ORDI (J.); BRABIN (B. J.); JOHNSON (P. M.)
AF :	MRC Laboratories, Atlantic Road/Fajara/Gambie (1 aut.); Child and Reproductive Health Group, Liverpool School of Tropical Medicine/Liverpool/Royaume-Uni (1 aut., 4 aut.); Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland/Auckland/Nouvelle-Zélande (2 aut.); Department d'Anatomia Patològica, Universitat de Barcelona/Barcelona/Espagne (3 aut.); Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam/Pays-Bas (4 aut.); Division of Immunology, University of Liverpool/Liverpool/Royaume-Uni (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Clinical and experimental immunology : (Print); ISSN 0009-9104; Coden CEXIAL; Royaume-Uni; Da. 2005; Vol. 142; No. 3; Pp. 512-518; Bibl. 28 ref.
LA :	Anglais
EA :	Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β₂ glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.
CC :	002B06; 002A06
FD :	Paludisme; Phospholipide; Anticorps; Parité; Placenta; Glycoprotéine β2; Diphosphatidylglycérol; Gestation
FG :	Protozoose; Parasitose; Infection; Immunologie; Immunopathologie; Annexe embryonnaire
ED :	Malaria; Phospholipid; Antibody; Parity; Placenta; β2 acid-Glycoprotein; Diphosphatidylglycerol; Pregnancy
EG :	Protozoal disease; Parasitosis; Infection; Immunology; Immunopathology; Fetal membrane
SD :	Paludismo; Fosfolípido; Anticuerpo; Paridad; Placenta; Glicoproteína β2; Difosfatidilglicerol; Gestación
LO :	INIST-12690.354000135196170150
ID :	06-0007882

Links to Exploration step

Pascal:06-0007882

Le document en format XML

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<front><div type="abstract" xml:lang="en">Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β<sub>2</sub>
 glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</div>
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<fC01 i1="01" l="ENG"><s0>Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β<sub>2</sub>
 glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B06</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A06</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Paludisme</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Malaria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Paludismo</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Phospholipide</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Phospholipid</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Fosfolípido</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Anticorps</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Antibody</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Anticuerpo</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Parité</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Parity</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Paridad</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Placenta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Placenta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Placenta</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Glycoprotéine β2</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>β2 acid-Glycoprotein</s0>
<s5>08</s5>
<s6>«β2 acid»-Glycoprotein</s6>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Glicoproteína β2</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Diphosphatidylglycérol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Diphosphatidylglycerol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Difosfatidilglicerol</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Gestation</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Pregnancy</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Gestación</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Protozoose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Protozoal disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Protozoosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Parasitose</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Parasitosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Parasitosis</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Immunologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Immunology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Inmunología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Immunopathologie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Immunopathology</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Inmunopatología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Annexe embryonnaire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Fetal membrane</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Membrana fetal</s0>
<s5>39</s5>
</fC07>
<fN21><s1>002</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
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<server><NO>PASCAL 06-0007882 INIST</NO>
<ET>The association of anti-phospholipid antibodies with parity in placental malaria</ET>
<AU>OWENS (S.); CHAMLEY (L. W.); ORDI (J.); BRABIN (B. J.); JOHNSON (P. M.)</AU>
<AF>MRC Laboratories, Atlantic Road/Fajara/Gambie (1 aut.); Child and Reproductive Health Group, Liverpool School of Tropical Medicine/Liverpool/Royaume-Uni (1 aut., 4 aut.); Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland/Auckland/Nouvelle-Zélande (2 aut.); Department d'Anatomia Patològica, Universitat de Barcelona/Barcelona/Espagne (3 aut.); Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam/Pays-Bas (4 aut.); Division of Immunology, University of Liverpool/Liverpool/Royaume-Uni (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical and experimental immunology : (Print); ISSN 0009-9104; Coden CEXIAL; Royaume-Uni; Da. 2005; Vol. 142; No. 3; Pp. 512-518; Bibl. 28 ref.</SO>
<LA>Anglais</LA>
<EA>Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β<sub>2</sub>
 glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</EA>
<CC>002B06; 002A06</CC>
<FD>Paludisme; Phospholipide; Anticorps; Parité; Placenta; Glycoprotéine β2; Diphosphatidylglycérol; Gestation</FD>
<FG>Protozoose; Parasitose; Infection; Immunologie; Immunopathologie; Annexe embryonnaire</FG>
<ED>Malaria; Phospholipid; Antibody; Parity; Placenta; β2 acid-Glycoprotein; Diphosphatidylglycerol; Pregnancy</ED>
<EG>Protozoal disease; Parasitosis; Infection; Immunology; Immunopathology; Fetal membrane</EG>
<SD>Paludismo; Fosfolípido; Anticuerpo; Paridad; Placenta; Glicoproteína β2; Difosfatidilglicerol; Gestación</SD>
<LO>INIST-12690.354000135196170150</LO>
<ID>06-0007882</ID>
</server>
</inist>
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The association of anti-phospholipid antibodies with parity in placental malaria

The association of anti-phospholipid antibodies with parity in placental malaria

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