The association of anti-phospholipid antibodies with parity in placental malaria
Identifieur interne : 000089 ( PascalFrancis/Checkpoint ); précédent : 000088; suivant : 000090The association of anti-phospholipid antibodies with parity in placental malaria
Auteurs : S. Owens [Gambie, Royaume-Uni] ; L. W. Chamley [Nouvelle-Zélande] ; J. Ordi [Espagne] ; B. J. Brabin [Royaume-Uni, Pays-Bas] ; P. M. Johnson [Royaume-Uni]Source :
- Clinical and experimental immunology : (Print) [ 0009-9104 ] ; 2005.
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- Pascal (Inist)
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- KwdEn :
Abstract
Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β2 glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.
Affiliations:
- Espagne, Gambie, Nouvelle-Zélande, Pays-Bas, Royaume-Uni
- Catalogne, Hollande-Septentrionale
- Amsterdam, Barcelone
- Université d'Amsterdam, Université de Barcelone
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Chamley</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3><sZ>2 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Ordi, J" sort="Ordi, J" uniqKey="Ordi J" first="J." last="Ordi">J. Ordi</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department d'Anatomia Patològica, Universitat de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B. J." last="Brabin">B. J. Brabin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Liverpool</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam</s1><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Johnson, P M" sort="Johnson, P M" uniqKey="Johnson P" first="P. M." last="Johnson">P. M. Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Immunology, University of Liverpool</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">06-0007882</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 06-0007882 INIST</idno><idno type="RBID">Pascal:06-0007882</idno><idno type="wicri:Area/PascalFrancis/Corpus">000101</idno><idno type="wicri:Area/PascalFrancis/Curation">000044</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000089</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000089</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The association of anti-phospholipid antibodies with parity in placental malaria</title><author><name sortKey="Owens, S" sort="Owens, S" uniqKey="Owens S" first="S." last="Owens">S. Owens</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>MRC Laboratories, Atlantic Road</s1><s2>Fajara</s2><s3>GMB</s3><sZ>1 aut.</sZ></inist:fA14><country>Gambie</country><wicri:noRegion>Fajara</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Chamley, L W" sort="Chamley, L W" uniqKey="Chamley L" first="L. W." last="Chamley">L. W. Chamley</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland</s1><s2>Auckland</s2><s3>NZL</s3><sZ>2 aut.</sZ></inist:fA14><country>Nouvelle-Zélande</country><wicri:noRegion>Auckland</wicri:noRegion></affiliation></author><author><name sortKey="Ordi, J" sort="Ordi, J" uniqKey="Ordi J" first="J." last="Ordi">J. Ordi</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department d'Anatomia Patològica, Universitat de Barcelona</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>3 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université de Barcelone</orgName></affiliation></author><author><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B. J." last="Brabin">B. J. Brabin</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Child and Reproductive Health Group, Liverpool School of Tropical Medicine</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Liverpool</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Emma Kinderziekenhuis, Academic Medical Centre, University of Amsterdam</s1><s3>NLD</s3><sZ>4 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Amsterdam</settlement><region>Hollande-Septentrionale</region></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Johnson, P M" sort="Johnson, P M" uniqKey="Johnson P" first="P. M." last="Johnson">P. M. Johnson</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Division of Immunology, University of Liverpool</s1><s2>Liverpool</s2><s3>GBR</s3><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Liverpool</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Clinical and experimental immunology : (Print)</title><title level="j" type="abbreviated">Clin. exp. immunol. : (Print)</title><idno type="ISSN">0009-9104</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical and experimental immunology : (Print)</title><title level="j" type="abbreviated">Clin. exp. immunol. : (Print)</title><idno type="ISSN">0009-9104</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibody</term><term>Diphosphatidylglycerol</term><term>Malaria</term><term>Parity</term><term>Phospholipid</term><term>Placenta</term><term>Pregnancy</term><term>β2 acid-Glycoprotein</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Paludisme</term><term>Phospholipide</term><term>Anticorps</term><term>Parité</term><term>Placenta</term><term>Glycoprotéine β2</term><term>Diphosphatidylglycérol</term><term>Gestation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Anti-phospholipid antibodies (aPL) are autoantibodies associated with both infections and the pathogenesis of certain pregnancy complications. In the latter, but not the former, aPL are dependent on a co-factor, β<sub>2</sub> glycoprotein I (β2GPI), which can also be used as an antigen for detection of such aPL in pregnancy. A cross-sectional study was carried out on serum samples from Kumasi, Ghana, to determine the occurrence and β2GPI-dependence of aPL in placental malaria. Anti-cardiolipin, anti-phosphatidylserine and anti-β2GPI enzyme-linked immunosorbent assays (ELISAs) were performed on sera from 103 HIV-non-infected gravid women. Placental malaria, both active and past infection, was diagnosed in 33/103 (32%) based on placental histology. In multiparae, β2GPI-independent IgM antibodies to cardiolipin (P = 0.018) and phosphatidylserine (P = 0.009) were observed, which were most pronounced in past placental malaria infection. In primiparae, no association emerged between aPL and placental malaria. Trends for improved clinical parameters were identified in infected women with levels of anti-cardiolipin beyond the 99th multiple of the median for a healthy, non-malarious population. This study in placental malaria reports parity associations of β2GPI-independent aPL profiles, and does not support a role for β2GPI-dependent aPL. It is of significance in the context of the known parity differences in pregnancy malaria immunity.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0009-9104</s0></fA01><fA02 i1="01"><s0>CEXIAL</s0></fA02><fA03 i2="1"><s0>Clin. exp. immunol. : (Print)</s0></fA03><fA05><s2>142</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The association of anti-phospholipid antibodies with parity in placental malaria</s1></fA08><fA11 i1="01" i2="1"><s1>OWENS (S.)</s1></fA11><fA11 i1="02" i2="1"><s1>CHAMLEY (L. W.)</s1></fA11><fA11 i1="03" i2="1"><s1>ORDI (J.)</s1></fA11><fA11 i1="04" i2="1"><s1>BRABIN (B. 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Owens</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Owens, S" sort="Owens, S" uniqKey="Owens S" first="S." last="Owens">S. Owens</name></noRegion><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B. J." last="Brabin">B. J. Brabin</name><name sortKey="Johnson, P M" sort="Johnson, P M" uniqKey="Johnson P" first="P. M." last="Johnson">P. M. Johnson</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Chamley, L W" sort="Chamley, L W" uniqKey="Chamley L" first="L. W." last="Chamley">L. W. Chamley</name></noRegion></country><country name="Espagne"><region name="Catalogne"><name sortKey="Ordi, J" sort="Ordi, J" uniqKey="Ordi J" first="J." last="Ordi">J. Ordi</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Brabin, B J" sort="Brabin, B J" uniqKey="Brabin B" first="B. J." last="Brabin">B. J. 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