SidaGhanaV1, Main, Merge, bibRecord, 000F58

Vertical transmission of HIV in ghanaian women diagnosed in cord blood and post-natal samples

Identifieur interne : 000F58 ( Main/Merge ); précédent : 000F57; suivant : 000F59

Vertical transmission of HIV in ghanaian women diagnosed in cord blood and post-natal samples

Auteurs : Lucia Fischetti [Royaume-Uni] ; Kwabena Danso [Ghana] ; Albert Dompreh [Ghana] ; Victor Addo [Ghana] ; Lars Haaheim [Norvège] ; Jean-Pierre Allain [Royaume-Uni]

Source :

Journal of medical virology [ 0146-6615 ] ; 2005.

RBID : Pascal:06-0256799

Descripteurs français

Pascal (Inist)
- Virus immunodéficience humaine, Homme, Transmission verticale, Femelle, Sang, Ghana, Charge virale, Soustype.
Wicri :
- geographic : Ghana.
- topic : Homme.

English descriptors

KwdEn :
- Blood, Female, Ghana, Human, Human immunodeficiency virus, Subtype, Vertical transmission, Viral load.

Abstract

HIV RNA detection in the newborn is the main diagnostic tool for vertical transmission. Most infections are thought to occur peri- or post-natally, hence preventive antiviral therapy administered days before and during delivery. This study used cord blood for molecular diagnosis, examined viral load and HIV-1 subtypes as determinants of transmission, and compared molecular variability of maternal, cord blood, and post-natal quasispecies. Ninety-seven seropositive mother-cord blood paired plasmas from Ghana were tested for HIV RNA. Viral load was quantified and a subgroup of 45 random women samples was typed and subtyped. HIV-1 from infected pairs was cloned, sequenced, and analyzed phylogenetically. The prevalence of HIV infection in pregnant women was 3.3%. 13/97 cord blood samples (13.5%) contained HIV RNA. No correlation between either viral load at labor (range 10³-10⁷) or HIV-1 subtype and in utero transmission wasfound. In both transmitting and non-transmitting mothers, 56% of HIV-1 strains were CRF02_AG. In three pairs, maternal and cord blood quasispecies were closely related, suggesting late pregnancy or perinatal transmission, while in four pairs, genetic distances suggested transmission earlier during gestation. Maternal viral load and genotype did not correlate with HIV-1 pre-natal transmission. HIV infection during gestation appears relatively frequent.

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Pascal:06-0256799

Le document en format XML

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<author><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name>
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<country>Royaume-Uni</country>
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<orgName type="university">Université de Cambridge</orgName>
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<author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
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<author><name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name>
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<author><name sortKey="Addo, Victor" sort="Addo, Victor" uniqKey="Addo V" first="Victor" last="Addo">Victor Addo</name>
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<sZ>4 aut.</sZ>
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<author><name sortKey="Haaheim, Lars" sort="Haaheim, Lars" uniqKey="Haaheim L" first="Lars" last="Haaheim">Lars Haaheim</name>
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<author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood</term>
<term>Female</term>
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<term>Subtype</term>
<term>Vertical transmission</term>
<term>Viral load</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Virus immunodéficience humaine</term>
<term>Homme</term>
<term>Transmission verticale</term>
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<term>Sang</term>
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<front><div type="abstract" xml:lang="en">HIV RNA detection in the newborn is the main diagnostic tool for vertical transmission. Most infections are thought to occur peri- or post-natally, hence preventive antiviral therapy administered days before and during delivery. This study used cord blood for molecular diagnosis, examined viral load and HIV-1 subtypes as determinants of transmission, and compared molecular variability of maternal, cord blood, and post-natal quasispecies. Ninety-seven seropositive mother-cord blood paired plasmas from Ghana were tested for HIV RNA. Viral load was quantified and a subgroup of 45 random women samples was typed and subtyped. HIV-1 from infected pairs was cloned, sequenced, and analyzed phylogenetically. The prevalence of HIV infection in pregnant women was 3.3%. 13/97 cord blood samples (13.5%) contained HIV RNA. No correlation between either viral load at labor (range 10<sup>3</sup>
-10<sup>7</sup>
) or HIV-1 subtype and in utero transmission wasfound. In both transmitting and non-transmitting mothers, 56% of HIV-1 strains were CRF02_AG. In three pairs, maternal and cord blood quasispecies were closely related, suggesting late pregnancy or perinatal transmission, while in four pairs, genetic distances suggested transmission earlier during gestation. Maternal viral load and genotype did not correlate with HIV-1 pre-natal transmission. HIV infection during gestation appears relatively frequent.</div>
</front>
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<affiliations><list><country><li>Ghana</li>
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<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Fischetti, Lucia" sort="Fischetti, Lucia" uniqKey="Fischetti L" first="Lucia" last="Fischetti">Lucia Fischetti</name>
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<name sortKey="Addo, Victor" sort="Addo, Victor" uniqKey="Addo V" first="Victor" last="Addo">Victor Addo</name>
<name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name>
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<country name="Norvège"><noRegion><name sortKey="Haaheim, Lars" sort="Haaheim, Lars" uniqKey="Haaheim L" first="Lars" last="Haaheim">Lars Haaheim</name>
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Le SIDA au Ghana (serveur d'exploration)

Vertical transmission of HIV in ghanaian women diagnosed in cord blood and post-natal samples

Vertical transmission of HIV in ghanaian women diagnosed in cord blood and post-natal samples

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri