Le SIDA au Ghana (serveur d'exploration)

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Deferred donor care in a regional hospital blood center in Ghana

Identifieur interne : 000A92 ( Main/Curation ); précédent : 000A91; suivant : 000A93

Deferred donor care in a regional hospital blood center in Ghana

Auteurs : Jean-Pierre Allain [Ghana] ; Ohene Opare-Sem [Ghana] ; Francis Sarkodie [Ghana] ; Rabiatu Rahman [Ghana] ; Shirley Owusu-Ofori [Ghana]

Source :

RBID : ISTEX:A62341EBA8A9B4616F6849448F7E756530C9B022

Descripteurs français

English descriptors

Abstract

BACKGROUND: In sub‐Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)‐ and hepatitis B virus (HBV)‐infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly pathogenic infections.

Url:
DOI: 10.1111/j.1537-2995.2008.02055.x

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ISTEX:A62341EBA8A9B4616F6849448F7E756530C9B022

Le document en format XML

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<div type="abstract">BACKGROUND: In sub‐Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)‐ and hepatitis B virus (HBV)‐infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly pathogenic infections.</div>
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<name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name>
</author>
</analytic>
<series>
<title level="j" type="main">Transfusion : (Philadelphia, PA)</title>
<title level="j" type="abbreviated">Transfusion : (Phila., PA)</title>
<idno type="ISSN">0041-1132</idno>
<imprint>
<date when="2009">2009</date>
</imprint>
</series>
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<title level="j" type="main">Transfusion : (Philadelphia, PA)</title>
<title level="j" type="abbreviated">Transfusion : (Phila., PA)</title>
<idno type="ISSN">0041-1132</idno>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Suboptimal donor</term>
<term>Transfusion</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Donneur limite</term>
<term>Transfusion</term>
</keywords>
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<div type="abstract" xml:lang="en">BACKGROUND: In sub-Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)- and hepatitis B virus (HBV)-infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly pathogenic infections. STUDY DESIGN AND METHODS: Between 2004 and 2007, all candidate donors deferred before donation for reactivity of anti-HIV, hepatitis C virus antibody (anti-HCV), and hepatitis B virus surface antigen (HBsAg) rapid tests were informed and referred to a donor care program consisting of test confirmation, information, counseling, and potential referral for follow-up and therapy. Dedicated trained nurses supervised the program including alanine aminotransferase (ALT) level testing to identify liver disease. RESULTS: In a 4-year period 51,100 donors were screened and 5778, 1578, and 227 candidate donors were deferred for reactivity to HBV, HIV, or HCV serologic markers, respectively. The rates of entry into the donor care program were 48, 14.3, and 22 percent of deferred donors, respectively. A total of 83 of 210 HBsAg-positive donors with elevated ALT levels were referred and 66 received antiviral treatment. A total of 89 of 516 confirmed anti-HIV-positive donors were referred to the hospital acquired immune deficiency syndrome clinic for follow-up. CONCLUSIONS: With little additional expense, the deferred donor care program identified asymptomatic infections with high odds of benefiting from monitoring and therapy. In the local circumstances, this public health-limited but definite impact was permitted by the rapid-test predonation screening, and this impact could be increased if more resources were available.</div>
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<name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
</author>
<author>
<name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name>
</author>
<author>
<name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name>
</author>
<author>
<name sortKey="Rahman, Rabiatu" sort="Rahman, Rabiatu" uniqKey="Rahman R" first="Rabiatu" last="Rahman">Rabiatu Rahman</name>
</author>
<author>
<name sortKey="Owusu Fori, Shirley" sort="Owusu Fori, Shirley" uniqKey="Owusu Fori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name>
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<name sortKey="Allain, Jean Ierre" sort="Allain, Jean Ierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; and the Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
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<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
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<name sortKey="Opare Em, Ohene" sort="Opare Em, Ohene" uniqKey="Opare Em O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name>
<affiliation wicri:level="4">
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; and the Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; and the Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
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<name sortKey="Rahman, Rabiatu" sort="Rahman, Rabiatu" uniqKey="Rahman R" first="Rabiatu" last="Rahman">Rabiatu Rahman</name>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; and the Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
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<name sortKey="Owusu Fori, Shirley" sort="Owusu Fori, Shirley" uniqKey="Owusu Fori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name>
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<country xml:lang="fr">Ghana</country>
<wicri:regionArea>From the Division of Transfusion Medicine, Department of Haematology, University of Cambridge, Cambridge, UK; and the Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
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<settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Allain</term>
<term>Antiviral treatment</term>
<term>Appointments and Schedules</term>
<term>Appropriate information</term>
<term>April</term>
<term>Asymptomatic</term>
<term>Blood Donors (statistics & numerical data)</term>
<term>Blood center</term>
<term>Blood donor</term>
<term>Blood donor screening</term>
<term>Blood donors</term>
<term>Blood safety</term>
<term>Blood testing</term>
<term>Candidate donors</term>
<term>Candotti</term>
<term>Communicable Diseases (blood)</term>
<term>Communicable Diseases (diagnosis)</term>
<term>Communicable Diseases (epidemiology)</term>
<term>Communicable Diseases (therapy)</term>
<term>Deferral</term>
<term>Delivery of Health Care (economics)</term>
<term>Delivery of Health Care (methods)</term>
<term>Delivery of Health Care (statistics & numerical data)</term>
<term>Donation</term>
<term>Donor</term>
<term>Donor care</term>
<term>Donor care program</term>
<term>Donor testing</term>
<term>Follow-Up Studies</term>
<term>General population</term>
<term>Ghana</term>
<term>Ghana (epidemiology)</term>
<term>Hbsag</term>
<term>Hematologic Tests (statistics & numerical data)</term>
<term>Hepatitis</term>
<term>Hepatocellular carcinoma</term>
<term>High odds</term>
<term>Hospital staff</term>
<term>Hospitals (statistics & numerical data)</term>
<term>Humans</term>
<term>Information sheet</term>
<term>Kath</term>
<term>Komfo anokye teaching hospital</term>
<term>Kumasi</term>
<term>Liver disease</term>
<term>Middle Aged</term>
<term>Outpatient aids clinic</term>
<term>Patient Selection</term>
<term>Personal health</term>
<term>Potential blood donors</term>
<term>Predonation</term>
<term>Predonation testing</term>
<term>Public health impact</term>
<term>Rapid tests</term>
<term>Reactive</term>
<term>Reactive tests</term>
<term>Regional Medical Programs (economics)</term>
<term>Regional Medical Programs (statistics & numerical data)</term>
<term>Regional hospital blood center</term>
<term>Replacement donors</term>
<term>Sarkodie</term>
<term>Secondary school students</term>
<term>Seroepidemiologic Studies</term>
<term>Transfusion</term>
<term>Transfusion medicine unit</term>
<term>Transfusion volume</term>
<term>Viral</term>
<term>Viral hepatitis</term>
<term>Viral infections</term>
<term>Viral marker</term>
<term>Virus infection</term>
<term>Volunteer</term>
<term>Volunteer donors</term>
<term>Volunteer population</term>
<term>West africa</term>
<term>Young Adult</term>
<term>Young students</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr">
<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Donneurs de sang ()</term>
<term>Ghana (épidémiologie)</term>
<term>Humains</term>
<term>Hôpitaux ()</term>
<term>Jeune adulte</term>
<term>Maladies transmissibles ()</term>
<term>Maladies transmissibles (diagnostic)</term>
<term>Maladies transmissibles (sang)</term>
<term>Maladies transmissibles (épidémiologie)</term>
<term>Prestations des soins de santé ()</term>
<term>Prestations des soins de santé (économie)</term>
<term>Programmes médicaux régionaux ()</term>
<term>Programmes médicaux régionaux (économie)</term>
<term>Rendez-vous et plannings</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sélection de patients</term>
<term>Tests hématologiques ()</term>
<term>Études de suivi</term>
<term>Études séroépidémiologiques</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en">
<term>Communicable Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Communicable Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr">
<term>Maladies transmissibles</term>
</keywords>
<keywords scheme="MESH" qualifier="economics" xml:lang="en">
<term>Delivery of Health Care</term>
<term>Regional Medical Programs</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Communicable Diseases</term>
</keywords>
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<term>Delivery of Health Care</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr">
<term>Maladies transmissibles</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en">
<term>Blood Donors</term>
<term>Delivery of Health Care</term>
<term>Hematologic Tests</term>
<term>Hospitals</term>
<term>Regional Medical Programs</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Communicable Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="économie" xml:lang="fr">
<term>Prestations des soins de santé</term>
<term>Programmes médicaux régionaux</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr">
<term>Ghana</term>
<term>Maladies transmissibles</term>
</keywords>
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<term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Allain</term>
<term>Antiviral treatment</term>
<term>Appointments and Schedules</term>
<term>Appropriate information</term>
<term>April</term>
<term>Asymptomatic</term>
<term>Blood center</term>
<term>Blood donor</term>
<term>Blood donor screening</term>
<term>Blood donors</term>
<term>Blood safety</term>
<term>Blood testing</term>
<term>Candidate donors</term>
<term>Candotti</term>
<term>Deferral</term>
<term>Donation</term>
<term>Donor</term>
<term>Donor care</term>
<term>Donor care program</term>
<term>Donor testing</term>
<term>Follow-Up Studies</term>
<term>General population</term>
<term>Ghana</term>
<term>Hbsag</term>
<term>Hepatitis</term>
<term>Hepatocellular carcinoma</term>
<term>High odds</term>
<term>Hospital staff</term>
<term>Humans</term>
<term>Information sheet</term>
<term>Kath</term>
<term>Komfo anokye teaching hospital</term>
<term>Kumasi</term>
<term>Liver disease</term>
<term>Middle Aged</term>
<term>Outpatient aids clinic</term>
<term>Patient Selection</term>
<term>Personal health</term>
<term>Potential blood donors</term>
<term>Predonation</term>
<term>Predonation testing</term>
<term>Public health impact</term>
<term>Rapid tests</term>
<term>Reactive</term>
<term>Reactive tests</term>
<term>Regional hospital blood center</term>
<term>Replacement donors</term>
<term>Sarkodie</term>
<term>Secondary school students</term>
<term>Seroepidemiologic Studies</term>
<term>Transfusion</term>
<term>Transfusion medicine unit</term>
<term>Transfusion volume</term>
<term>Viral</term>
<term>Viral hepatitis</term>
<term>Viral infections</term>
<term>Viral marker</term>
<term>Virus infection</term>
<term>Volunteer</term>
<term>Volunteer donors</term>
<term>Volunteer population</term>
<term>West africa</term>
<term>Young Adult</term>
<term>Young students</term>
</keywords>
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<term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Donneurs de sang</term>
<term>Ghana</term>
<term>Humains</term>
<term>Hôpitaux</term>
<term>Jeune adulte</term>
<term>Maladies transmissibles</term>
<term>Prestations des soins de santé</term>
<term>Programmes médicaux régionaux</term>
<term>Rendez-vous et plannings</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Sélection de patients</term>
<term>Tests hématologiques</term>
<term>Études de suivi</term>
<term>Études séroépidémiologiques</term>
</keywords>
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<term>Don</term>
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<div type="abstract">BACKGROUND: In sub‐Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)‐ and hepatitis B virus (HBV)‐infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly pathogenic infections.</div>
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