Deferred donor care in a regional hospital blood center in Ghana
Identifieur interne : 000B33 ( Main/Merge ); précédent : 000B32; suivant : 000B34Deferred donor care in a regional hospital blood center in Ghana
Auteurs : Jean-Pierre Allain [Royaume-Uni, Ghana] ; Ohene Opare-Sem ; Francis Sarkodie ; Rabiatu Rahman ; Shirley Owusu-OforiSource :
- Transfusion : (Philadelphia, PA) [ 0041-1132 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
BACKGROUND: In sub-Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)- and hepatitis B virus (HBV)-infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly pathogenic infections. STUDY DESIGN AND METHODS: Between 2004 and 2007, all candidate donors deferred before donation for reactivity of anti-HIV, hepatitis C virus antibody (anti-HCV), and hepatitis B virus surface antigen (HBsAg) rapid tests were informed and referred to a donor care program consisting of test confirmation, information, counseling, and potential referral for follow-up and therapy. Dedicated trained nurses supervised the program including alanine aminotransferase (ALT) level testing to identify liver disease. RESULTS: In a 4-year period 51,100 donors were screened and 5778, 1578, and 227 candidate donors were deferred for reactivity to HBV, HIV, or HCV serologic markers, respectively. The rates of entry into the donor care program were 48, 14.3, and 22 percent of deferred donors, respectively. A total of 83 of 210 HBsAg-positive donors with elevated ALT levels were referred and 66 received antiviral treatment. A total of 89 of 516 confirmed anti-HIV-positive donors were referred to the hospital acquired immune deficiency syndrome clinic for follow-up. CONCLUSIONS: With little additional expense, the deferred donor care program identified asymptomatic infections with high odds of benefiting from monitoring and therapy. In the local circumstances, this public health-limited but definite impact was permitted by the rapid-test predonation screening, and this impact could be increased if more resources were available.
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Pascal:09-0186728Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Deferred donor care in a regional hospital blood center in Ghana</title><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital</s1><s2>Kumasi</s2><s3>GHA</s3></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></author><author><name sortKey="Rahman, Rabiatu" sort="Rahman, Rabiatu" uniqKey="Rahman R" first="Rabiatu" last="Rahman">Rabiatu Rahman</name></author><author><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">09-0186728</idno><date when="2009">2009</date><idno type="stanalyst">PASCAL 09-0186728 INIST</idno><idno type="RBID">Pascal:09-0186728</idno><idno type="wicri:Area/PascalFrancis/Corpus">000058</idno><idno type="wicri:Area/PascalFrancis/Curation">000079</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000045</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000045</idno><idno type="wicri:doubleKey">0041-1132:2009:Allain J:deferred:donor:care</idno><idno type="wicri:Area/Main/Merge">000B33</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Deferred donor care in a regional hospital blood center in Ghana</title><author><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Division of Transfusion Medicine, Department of Haematology, University of Cambridge</s1><s2>Cambridge</s2><s3>GBR</s3></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Medicine, and the Transfusion Medicine Unit, Komfo Anokye Teaching Hospital</s1><s2>Kumasi</s2><s3>GHA</s3></inist:fA14><country>Ghana</country><wicri:noRegion>Kumasi</wicri:noRegion></affiliation></author><author><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name></author><author><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></author><author><name sortKey="Rahman, Rabiatu" sort="Rahman, Rabiatu" uniqKey="Rahman R" first="Rabiatu" last="Rahman">Rabiatu Rahman</name></author><author><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name></author></analytic><series><title level="j" type="main">Transfusion : (Philadelphia, PA)</title><title level="j" type="abbreviated">Transfusion : (Phila., PA)</title><idno type="ISSN">0041-1132</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Transfusion : (Philadelphia, PA)</title><title level="j" type="abbreviated">Transfusion : (Phila., PA)</title><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Suboptimal donor</term><term>Transfusion</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Donneur limite</term><term>Transfusion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: In sub-Saharan Africa, the viral marker burden in blood donor populations ranges between 10 and 30 percent. Deferred donors constitute a rare population of asymptomatic human immunodeficiency virus (HIV)- and hepatitis B virus (HBV)-infected individuals with high likelihood of long survival if cared for. Deferred donor care provides an opportunity for a public health impact on highly pathogenic infections. STUDY DESIGN AND METHODS: Between 2004 and 2007, all candidate donors deferred before donation for reactivity of anti-HIV, hepatitis C virus antibody (anti-HCV), and hepatitis B virus surface antigen (HBsAg) rapid tests were informed and referred to a donor care program consisting of test confirmation, information, counseling, and potential referral for follow-up and therapy. Dedicated trained nurses supervised the program including alanine aminotransferase (ALT) level testing to identify liver disease. RESULTS: In a 4-year period 51,100 donors were screened and 5778, 1578, and 227 candidate donors were deferred for reactivity to HBV, HIV, or HCV serologic markers, respectively. The rates of entry into the donor care program were 48, 14.3, and 22 percent of deferred donors, respectively. A total of 83 of 210 HBsAg-positive donors with elevated ALT levels were referred and 66 received antiviral treatment. A total of 89 of 516 confirmed anti-HIV-positive donors were referred to the hospital acquired immune deficiency syndrome clinic for follow-up. CONCLUSIONS: With little additional expense, the deferred donor care program identified asymptomatic infections with high odds of benefiting from monitoring and therapy. In the local circumstances, this public health-limited but definite impact was permitted by the rapid-test predonation screening, and this impact could be increased if more resources were available.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><noCountry><name sortKey="Opare Sem, Ohene" sort="Opare Sem, Ohene" uniqKey="Opare Sem O" first="Ohene" last="Opare-Sem">Ohene Opare-Sem</name><name sortKey="Owusu Ofori, Shirley" sort="Owusu Ofori, Shirley" uniqKey="Owusu Ofori S" first="Shirley" last="Owusu-Ofori">Shirley Owusu-Ofori</name><name sortKey="Rahman, Rabiatu" sort="Rahman, Rabiatu" uniqKey="Rahman R" first="Rabiatu" last="Rahman">Rabiatu Rahman</name><name sortKey="Sarkodie, Francis" sort="Sarkodie, Francis" uniqKey="Sarkodie F" first="Francis" last="Sarkodie">Francis Sarkodie</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name></region></country><country name="Ghana"><noRegion><name sortKey="Allain, Jean Pierre" sort="Allain, Jean Pierre" uniqKey="Allain J" first="Jean-Pierre" last="Allain">Jean-Pierre Allain</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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