Effect of Modified Otago Exercises on Postural Balance, Fear of Falling, and Fall Risk in Older Fallers With Knee Osteoarthritis and Impaired Gait and Balance: A Secondary Analysis.
Identifieur interne : 000493 ( Main/Curation ); précédent : 000492; suivant : 000494Effect of Modified Otago Exercises on Postural Balance, Fear of Falling, and Fall Risk in Older Fallers With Knee Osteoarthritis and Impaired Gait and Balance: A Secondary Analysis.
Auteurs : Sumaiyah Mat [Malaisie, Singapour, Australie] ; Chin Teck Ng [Malaisie, Singapour, Australie] ; Pey June Tan [Malaisie, Singapour, Australie] ; Norlisah Ramli [Malaisie, Singapour, Australie] ; Farhana Fadzli [Malaisie, Singapour, Australie] ; Faizatul Izza Rozalli [Malaisie, Singapour, Australie] ; Mazlina Mazlan [Malaisie, Singapour, Australie] ; Keith D. Hill [Malaisie, Singapour, Australie] ; Maw Pin Tan [Malaisie, Singapour, Australie]Source :
- PM & R : the journal of injury, function, and rehabilitation [ 1934-1563 ] ; 2018.
Descripteurs français
- KwdFr :
- Articulation du genou (physiopathologie), Chutes accidentelles (prévention et contrôle), Chutes accidentelles (statistiques et données numériques), Démarche (physiologie), Facteurs de risque (MeSH), Femelle (MeSH), Gonarthrose (complications), Gonarthrose (physiopathologie), Gonarthrose (rééducation et réadaptation), Humains (MeSH), Mâle (MeSH), Peur (psychologie), Sujet âgé (MeSH), Traitement par les exercices physiques (méthodes), Équilibre postural (physiologie), Études de suivi (MeSH), Études rétrospectives (MeSH).
- MESH :
- méthodes : Traitement par les exercices physiques.
- physiologie : Démarche, Équilibre postural.
- physiopathologie : Articulation du genou, Gonarthrose.
- prévention et contrôle : Chutes accidentelles.
- psychologie : Peur.
- rééducation et réadaptation : Gonarthrose.
- statistiques et données numériques : Chutes accidentelles.
- complications : Facteurs de risque, Femelle, Gonarthrose, Humains, Mâle, Sujet âgé, Études de suivi, Études rétrospectives.
English descriptors
- KwdEn :
- Accidental Falls (prevention & control), Accidental Falls (statistics & numerical data), Aged (MeSH), Exercise Therapy (methods), Fear (psychology), Female (MeSH), Follow-Up Studies (MeSH), Gait (physiology), Humans (MeSH), Knee Joint (physiopathology), Male (MeSH), Osteoarthritis, Knee (complications), Osteoarthritis, Knee (physiopathology), Osteoarthritis, Knee (rehabilitation), Postural Balance (physiology), Retrospective Studies (MeSH), Risk Factors (MeSH).
- MESH :
- complications : Osteoarthritis, Knee.
- methods : Exercise Therapy.
- physiology : Gait, Postural Balance.
- physiopathology : Knee Joint, Osteoarthritis, Knee.
- prevention & control : Accidental Falls.
- psychology : Fear.
- rehabilitation : Osteoarthritis, Knee.
- statistics & numerical data : Accidental Falls.
- Aged, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Risk Factors.
Abstract
BACKGROUND
Osteoarthritis (OA) is considered an established risk factor for falls. Published studies evaluating secondary falls prevention strategies among individuals with OA are limited.
OBJECTIVE
To evaluate the effect of a personalized home-based exercise program to improve postural balance, fear of falling, and falls risk in older fallers with knee OA and gait and balance problems.
DESIGN
Randomized controlled trial.
SETTING
University of Malaya Medical Centre.
PARTICIPANTS
Fallers who had both radiological OA and a Timed Up and Go (TUG) score of over 13.5 seconds.
MAIN OUTCOME MEASURE
Postural sway (composite sway) was quantified with the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) under 4 different sensory conditions: eyes open on firm surface, eyes closed on firm surface, eyes open on unstable foam surface, and eyes closed on unstable foam surface. Participants were asked to stand upright and to attempt to hold their position for 10 seconds for each test condition. The average reading for all conditions were calculated.
METHODS
Participants randomized to the intervention arm received a home-based modified Otago Exercise Program (OEP) as part of a multifactorial intervention, whereas control participants received general health advice and conventional treatment. This was a secondary subgroup analysis from an original randomized controlled trial, the Malaysian Falls Assessment and Intervention Trial (MyFAIT) (trial registration number: ISRCTN11674947). Posturography using a long force plate balance platform (Balancemaster, NeuroCom, USA), the Knee injury and Osteoarthritis Outcome Score (KOOS) and the short-form Falls Efficacy Scale-International (short FES-I) were assessed at baseline and 6 months.
RESULTS
Results of 41 fallers with radiological evidence of OA and impaired TUG (intervention, 17; control, 24) were available for the final analysis. Between-group analysis revealed significant improvements in the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB), Limits of Stability (LOS), and short FES-I scores by the intervention group compared to the control group at 6 months. No significant difference in time to first fall or in fall-free survival between the intervention and control groups was found.
CONCLUSION
Home-based balance and strength exercises benefited older fallers with OA and gait and balance disorders by improving postural control, with no observable trend in reduction of fall recurrence. Our findings will now inform a future, adequately powered, randomized controlled study using fall events as definitive outcomes.
LEVEL OF EVIDENCE
I.
DOI: 10.1016/j.pmrj.2017.08.405
PubMed: 28827207
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<author><name sortKey="Tan, Pey June" sort="Tan, Pey June" uniqKey="Tan P" first="Pey June" last="Tan">Pey June Tan</name>
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<author><name sortKey="Ramli, Norlisah" sort="Ramli, Norlisah" uniqKey="Ramli N" first="Norlisah" last="Ramli">Norlisah Ramli</name>
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<country xml:lang="fr">Singapour</country>
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<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
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<country xml:lang="fr">Malaisie</country>
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<author><name sortKey="Fadzli, Farhana" sort="Fadzli, Farhana" uniqKey="Fadzli F" first="Farhana" last="Fadzli">Farhana Fadzli</name>
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<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
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<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
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</author>
<author><name sortKey="Rozalli, Faizatul Izza" sort="Rozalli, Faizatul Izza" uniqKey="Rozalli F" first="Faizatul Izza" last="Rozalli">Faizatul Izza Rozalli</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
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</author>
<author><name sortKey="Mazlan, Mazlina" sort="Mazlan, Mazlina" uniqKey="Mazlan M" first="Mazlina" last="Mazlan">Mazlina Mazlan</name>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
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<author><name sortKey="Hill, Keith D" sort="Hill, Keith D" uniqKey="Hill K" first="Keith D" last="Hill">Keith D. Hill</name>
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<country xml:lang="fr">Malaisie</country>
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<country xml:lang="fr">Singapour</country>
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<country xml:lang="fr">Singapour</country>
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<country xml:lang="fr">Malaisie</country>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
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<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
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<placeName><region type="state">Australie-Occidentale</region>
</placeName>
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</author>
<author><name sortKey="Tan, Maw Pin" sort="Tan, Maw Pin" uniqKey="Tan M" first="Maw Pin" last="Tan">Maw Pin Tan</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of Modified Otago Exercises on Postural Balance, Fear of Falling, and Fall Risk in Older Fallers With Knee Osteoarthritis and Impaired Gait and Balance: A Secondary Analysis.</title>
<author><name sortKey="Mat, Sumaiyah" sort="Mat, Sumaiyah" uniqKey="Mat S" first="Sumaiyah" last="Mat">Sumaiyah Mat</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ng, Chin Teck" sort="Ng, Chin Teck" uniqKey="Ng C" first="Chin Teck" last="Ng">Chin Teck Ng</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
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</author>
<author><name sortKey="Tan, Pey June" sort="Tan, Pey June" uniqKey="Tan P" first="Pey June" last="Tan">Pey June Tan</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ramli, Norlisah" sort="Ramli, Norlisah" uniqKey="Ramli N" first="Norlisah" last="Ramli">Norlisah Ramli</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fadzli, Farhana" sort="Fadzli, Farhana" uniqKey="Fadzli F" first="Farhana" last="Fadzli">Farhana Fadzli</name>
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<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rozalli, Faizatul Izza" sort="Rozalli, Faizatul Izza" uniqKey="Rozalli F" first="Faizatul Izza" last="Rozalli">Faizatul Izza Rozalli</name>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mazlan, Mazlina" sort="Mazlan, Mazlina" uniqKey="Mazlan M" first="Mazlina" last="Mazlan">Mazlina Mazlan</name>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hill, Keith D" sort="Hill, Keith D" uniqKey="Hill K" first="Keith D" last="Hill">Keith D. Hill</name>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tan, Maw Pin" sort="Tan, Maw Pin" uniqKey="Tan M" first="Maw Pin" last="Tan">Maw Pin Tan</name>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</nlm:affiliation>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</nlm:affiliation>
<country>Australie</country>
<placeName><region type="state">Australie-Occidentale</region>
</placeName>
<wicri:cityArea>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</nlm:affiliation>
<country xml:lang="fr">Malaisie</country>
<wicri:regionArea>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">PM & R : the journal of injury, function, and rehabilitation</title>
<idno type="eISSN">1934-1563</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls (prevention & control)</term>
<term>Accidental Falls (statistics & numerical data)</term>
<term>Aged (MeSH)</term>
<term>Exercise Therapy (methods)</term>
<term>Fear (psychology)</term>
<term>Female (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Gait (physiology)</term>
<term>Humans (MeSH)</term>
<term>Knee Joint (physiopathology)</term>
<term>Male (MeSH)</term>
<term>Osteoarthritis, Knee (complications)</term>
<term>Osteoarthritis, Knee (physiopathology)</term>
<term>Osteoarthritis, Knee (rehabilitation)</term>
<term>Postural Balance (physiology)</term>
<term>Retrospective Studies (MeSH)</term>
<term>Risk Factors (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Articulation du genou (physiopathologie)</term>
<term>Chutes accidentelles (prévention et contrôle)</term>
<term>Chutes accidentelles (statistiques et données numériques)</term>
<term>Démarche (physiologie)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Gonarthrose (complications)</term>
<term>Gonarthrose (physiopathologie)</term>
<term>Gonarthrose (rééducation et réadaptation)</term>
<term>Humains (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Peur (psychologie)</term>
<term>Sujet âgé (MeSH)</term>
<term>Traitement par les exercices physiques (méthodes)</term>
<term>Équilibre postural (physiologie)</term>
<term>Études de suivi (MeSH)</term>
<term>Études rétrospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Osteoarthritis, Knee</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Exercise Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Traitement par les exercices physiques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Démarche</term>
<term>Équilibre postural</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term>
<term>Postural Balance</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Articulation du genou</term>
<term>Gonarthrose</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Knee Joint</term>
<term>Osteoarthritis, Knee</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Accidental Falls</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Chutes accidentelles</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Peur</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Fear</term>
</keywords>
<keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Osteoarthritis, Knee</term>
</keywords>
<keywords scheme="MESH" qualifier="rééducation et réadaptation" xml:lang="fr"><term>Gonarthrose</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Accidental Falls</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Chutes accidentelles</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Retrospective Studies</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="fr"><term>Facteurs de risque</term>
<term>Femelle</term>
<term>Gonarthrose</term>
<term>Humains</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Études de suivi</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Osteoarthritis (OA) is considered an established risk factor for falls. Published studies evaluating secondary falls prevention strategies among individuals with OA are limited.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>To evaluate the effect of a personalized home-based exercise program to improve postural balance, fear of falling, and falls risk in older fallers with knee OA and gait and balance problems.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>DESIGN</b>
</p>
<p>Randomized controlled trial.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>SETTING</b>
</p>
<p>University of Malaya Medical Centre.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>PARTICIPANTS</b>
</p>
<p>Fallers who had both radiological OA and a Timed Up and Go (TUG) score of over 13.5 seconds.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>MAIN OUTCOME MEASURE</b>
</p>
<p>Postural sway (composite sway) was quantified with the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) under 4 different sensory conditions: eyes open on firm surface, eyes closed on firm surface, eyes open on unstable foam surface, and eyes closed on unstable foam surface. Participants were asked to stand upright and to attempt to hold their position for 10 seconds for each test condition. The average reading for all conditions were calculated.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Participants randomized to the intervention arm received a home-based modified Otago Exercise Program (OEP) as part of a multifactorial intervention, whereas control participants received general health advice and conventional treatment. This was a secondary subgroup analysis from an original randomized controlled trial, the Malaysian Falls Assessment and Intervention Trial (MyFAIT) (trial registration number: ISRCTN11674947). Posturography using a long force plate balance platform (Balancemaster, NeuroCom, USA), the Knee injury and Osteoarthritis Outcome Score (KOOS) and the short-form Falls Efficacy Scale-International (short FES-I) were assessed at baseline and 6 months.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Results of 41 fallers with radiological evidence of OA and impaired TUG (intervention, 17; control, 24) were available for the final analysis. Between-group analysis revealed significant improvements in the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB), Limits of Stability (LOS), and short FES-I scores by the intervention group compared to the control group at 6 months. No significant difference in time to first fall or in fall-free survival between the intervention and control groups was found.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Home-based balance and strength exercises benefited older fallers with OA and gait and balance disorders by improving postural control, with no observable trend in reduction of fall recurrence. Our findings will now inform a future, adequately powered, randomized controlled study using fall events as definitive outcomes.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>LEVEL OF EVIDENCE</b>
</p>
<p>I.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28827207</PMID>
<DateCompleted><Year>2019</Year>
<Month>10</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>10</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1934-1563</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>3</Issue>
<PubDate><Year>2018</Year>
<Month>03</Month>
</PubDate>
</JournalIssue>
<Title>PM & R : the journal of injury, function, and rehabilitation</Title>
<ISOAbbreviation>PM R</ISOAbbreviation>
</Journal>
<ArticleTitle>Effect of Modified Otago Exercises on Postural Balance, Fear of Falling, and Fall Risk in Older Fallers With Knee Osteoarthritis and Impaired Gait and Balance: A Secondary Analysis.</ArticleTitle>
<Pagination><MedlinePgn>254-262</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.pmrj.2017.08.405</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Osteoarthritis (OA) is considered an established risk factor for falls. Published studies evaluating secondary falls prevention strategies among individuals with OA are limited.</AbstractText>
<AbstractText Label="OBJECTIVE">To evaluate the effect of a personalized home-based exercise program to improve postural balance, fear of falling, and falls risk in older fallers with knee OA and gait and balance problems.</AbstractText>
<AbstractText Label="DESIGN">Randomized controlled trial.</AbstractText>
<AbstractText Label="SETTING">University of Malaya Medical Centre.</AbstractText>
<AbstractText Label="PARTICIPANTS">Fallers who had both radiological OA and a Timed Up and Go (TUG) score of over 13.5 seconds.</AbstractText>
<AbstractText Label="MAIN OUTCOME MEASURE">Postural sway (composite sway) was quantified with the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB) under 4 different sensory conditions: eyes open on firm surface, eyes closed on firm surface, eyes open on unstable foam surface, and eyes closed on unstable foam surface. Participants were asked to stand upright and to attempt to hold their position for 10 seconds for each test condition. The average reading for all conditions were calculated.</AbstractText>
<AbstractText Label="METHODS">Participants randomized to the intervention arm received a home-based modified Otago Exercise Program (OEP) as part of a multifactorial intervention, whereas control participants received general health advice and conventional treatment. This was a secondary subgroup analysis from an original randomized controlled trial, the Malaysian Falls Assessment and Intervention Trial (MyFAIT) (trial registration number: ISRCTN11674947). Posturography using a long force plate balance platform (Balancemaster, NeuroCom, USA), the Knee injury and Osteoarthritis Outcome Score (KOOS) and the short-form Falls Efficacy Scale-International (short FES-I) were assessed at baseline and 6 months.</AbstractText>
<AbstractText Label="RESULTS">Results of 41 fallers with radiological evidence of OA and impaired TUG (intervention, 17; control, 24) were available for the final analysis. Between-group analysis revealed significant improvements in the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB), Limits of Stability (LOS), and short FES-I scores by the intervention group compared to the control group at 6 months. No significant difference in time to first fall or in fall-free survival between the intervention and control groups was found.</AbstractText>
<AbstractText Label="CONCLUSION">Home-based balance and strength exercises benefited older fallers with OA and gait and balance disorders by improving postural control, with no observable trend in reduction of fall recurrence. Our findings will now inform a future, adequately powered, randomized controlled study using fall events as definitive outcomes.</AbstractText>
<AbstractText Label="LEVEL OF EVIDENCE">I.</AbstractText>
<CopyrightInformation>Copyright © 2018 American Academy of Physical Medicine and Rehabilitation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mat</LastName>
<ForeName>Sumaiyah</ForeName>
<Initials>S</Initials>
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<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<Initials>N</Initials>
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<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<ForeName>Farhana</ForeName>
<Initials>F</Initials>
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</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</Affiliation>
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<AffiliationInfo><Affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<Author ValidYN="Y"><LastName>Rozalli</LastName>
<ForeName>Faizatul Izza</ForeName>
<Initials>FI</Initials>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</Affiliation>
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<AffiliationInfo><Affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<ForeName>Mazlina</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</Affiliation>
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<AffiliationInfo><Affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<AffiliationInfo><Affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Hill</LastName>
<ForeName>Keith D</ForeName>
<Initials>KD</Initials>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</Affiliation>
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<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</Affiliation>
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<AffiliationInfo><Affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<AffiliationInfo><Affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<Author ValidYN="Y"><LastName>Tan</LastName>
<ForeName>Maw Pin</ForeName>
<Initials>MP</Initials>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Duke-NUS Medical School, National University Singapore, Singapore.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia; Health Services and Policy Research Division, Geriatric Education and Research Institute, Singapore.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Malaya Research Imaging Centre, Department of Biomedical Imaging, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Physiotherapy and Exercise Science, Faculty of Health Sciences, Curtin University, Bentley, Perth, Western Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Ageing and Age-Associated Disorders Research Group and Department of Medicine, Faculty of Medicine, Jalan Universiti, University of Malaya, 50603, Wilayah Persekutuan Kuala Lumpur, Malaysia.</Affiliation>
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<Month>08</Month>
<Day>18</Day>
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<ISSNLinking>1934-1482</ISSNLinking>
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<MeshHeading><DescriptorName UI="D005081" MajorTopicYN="N">Exercise Therapy</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
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<MeshHeading><DescriptorName UI="D005239" MajorTopicYN="N">Fear</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005684" MajorTopicYN="N">Gait</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007719" MajorTopicYN="N">Knee Joint</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020370" MajorTopicYN="N">Osteoarthritis, Knee</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
<QualifierName UI="Q000534" MajorTopicYN="Y">rehabilitation</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004856" MajorTopicYN="N">Postural Balance</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
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<PubMedPubDate PubStatus="revised"><Year>2017</Year>
<Month>08</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>08</Month>
<Day>05</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2017</Year>
<Month>8</Month>
<Day>23</Day>
<Hour>6</Hour>
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<Hour>6</Hour>
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<ArticleId IdType="doi">10.1016/j.pmrj.2017.08.405</ArticleId>
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