Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia
Identifieur interne : 002584 ( Main/Exploration ); précédent : 002583; suivant : 002585Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia
Auteurs : Volker Kühlkamp [Allemagne] ; Christian Mewis [Allemagne] ; Ludger Seipel [Allemagne]Source :
- International Journal of Cardiology [ 0167-5273 ] ; 1992.
Abstract
The electrophysiologic effects of pentisomide were investigated after intravenous (5 mg/kg) and oral (900–1200 mg three times a day) application in 9 patients with drug refractory atrioventricular nodal tachycardia and 6 patients with orthodromic atrioventricular re-entrant tachycardia. Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle and the atrioventricular node. AH, HV interval, effective refractory period of the right atrium, QRS duration and QTc duration were (p ≤ 0.01) increased. Tachycardia cycle length was only increased after intravenous application of pentisomide, antegrade effective refractory periods of the accessory pathways and shortest fully pre-excited R-R intervals during atrial fibrillation were increased after the oral treatment phase (p = 0.054). Intravenous pentisomide prevented tachycardia in 69 patients with atrioventricular nodal tachycardia and in 26 patients with atrioventricular re-entrant tachycardia. If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either. During long-term follow-up 27 patients with atrioventricular nodal tachycardia and 14 patient with atrioventricular re-entrant tachycardia had a recurrence. Long-term treatment with pentisomide had to be discontinued because of possible side effects in 2 patients. It is concluded, that the electrophysiological effects of pentisomide are similar to those of flecainide and propafenone.
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DOI: 10.1016/0167-5273(92)90110-O
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<front><div type="abstract" xml:lang="en">The electrophysiologic effects of pentisomide were investigated after intravenous (5 mg/kg) and oral (900–1200 mg three times a day) application in 9 patients with drug refractory atrioventricular nodal tachycardia and 6 patients with orthodromic atrioventricular re-entrant tachycardia. Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle and the atrioventricular node. AH, HV interval, effective refractory period of the right atrium, QRS duration and QTc duration were (p ≤ 0.01) increased. Tachycardia cycle length was only increased after intravenous application of pentisomide, antegrade effective refractory periods of the accessory pathways and shortest fully pre-excited R-R intervals during atrial fibrillation were increased after the oral treatment phase (p = 0.054). Intravenous pentisomide prevented tachycardia in 69 patients with atrioventricular nodal tachycardia and in 26 patients with atrioventricular re-entrant tachycardia. If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either. During long-term follow-up 27 patients with atrioventricular nodal tachycardia and 14 patient with atrioventricular re-entrant tachycardia had a recurrence. Long-term treatment with pentisomide had to be discontinued because of possible side effects in 2 patients. It is concluded, that the electrophysiological effects of pentisomide are similar to those of flecainide and propafenone.</div>
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