Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia
Identifieur interne : 001022 ( Main/Curation ); précédent : 001021; suivant : 001023Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia
Auteurs : Volker Kühlkamp [Allemagne] ; Christian Mewis [Allemagne] ; Ludger Seipel [Allemagne]Source :
- International Journal of Cardiology [ 0167-5273 ] ; 1992.
Abstract
The electrophysiologic effects of pentisomide were investigated after intravenous (5 mg/kg) and oral (900–1200 mg three times a day) application in 9 patients with drug refractory atrioventricular nodal tachycardia and 6 patients with orthodromic atrioventricular re-entrant tachycardia. Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle and the atrioventricular node. AH, HV interval, effective refractory period of the right atrium, QRS duration and QTc duration were (p ≤ 0.01) increased. Tachycardia cycle length was only increased after intravenous application of pentisomide, antegrade effective refractory periods of the accessory pathways and shortest fully pre-excited R-R intervals during atrial fibrillation were increased after the oral treatment phase (p = 0.054). Intravenous pentisomide prevented tachycardia in 69 patients with atrioventricular nodal tachycardia and in 26 patients with atrioventricular re-entrant tachycardia. If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either. During long-term follow-up 27 patients with atrioventricular nodal tachycardia and 14 patient with atrioventricular re-entrant tachycardia had a recurrence. Long-term treatment with pentisomide had to be discontinued because of possible side effects in 2 patients. It is concluded, that the electrophysiological effects of pentisomide are similar to those of flecainide and propafenone.
Url:
DOI: 10.1016/0167-5273(92)90110-O
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001223
Links to Exploration step
ISTEX:04D7D7F767F9F3104FAC178805B6E200C1604262Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia</title><author><name sortKey="Kuhlkamp, Volker" sort="Kuhlkamp, Volker" uniqKey="Kuhlkamp V" first="Volker" last="Kühlkamp">Volker Kühlkamp</name><affiliation wicri:level="1"><mods:affiliation>Medizinische Klinik Abteilung III, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik Abteilung III, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Mewis, Christian" sort="Mewis, Christian" uniqKey="Mewis C" first="Christian" last="Mewis">Christian Mewis</name><affiliation wicri:level="1"><mods:affiliation>Medizinische Klinik Abteilung III, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik Abteilung III, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Seipel, Ludger" sort="Seipel, Ludger" uniqKey="Seipel L" first="Ludger" last="Seipel">Ludger Seipel</name><affiliation wicri:level="1"><mods:affiliation>Medizinische Klinik Abteilung III, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik Abteilung III, Tübingen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:04D7D7F767F9F3104FAC178805B6E200C1604262</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0167-5273(92)90110-O</idno><idno type="url">https://api.istex.fr/document/04D7D7F767F9F3104FAC178805B6E200C1604262/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001223</idno><idno type="wicri:Area/Main/Curation">001022</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia</title><author><name sortKey="Kuhlkamp, Volker" sort="Kuhlkamp, Volker" uniqKey="Kuhlkamp V" first="Volker" last="Kühlkamp">Volker Kühlkamp</name><affiliation wicri:level="1"><mods:affiliation>Medizinische Klinik Abteilung III, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik Abteilung III, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Mewis, Christian" sort="Mewis, Christian" uniqKey="Mewis C" first="Christian" last="Mewis">Christian Mewis</name><affiliation wicri:level="1"><mods:affiliation>Medizinische Klinik Abteilung III, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik Abteilung III, Tübingen</wicri:regionArea></affiliation></author><author><name sortKey="Seipel, Ludger" sort="Seipel, Ludger" uniqKey="Seipel L" first="Ludger" last="Seipel">Ludger Seipel</name><affiliation wicri:level="1"><mods:affiliation>Medizinische Klinik Abteilung III, Tübingen, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medizinische Klinik Abteilung III, Tübingen</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Cardiology</title><title level="j" type="abbrev">IJCA</title><idno type="ISSN">0167-5273</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">36</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="69">69</biblScope><biblScope unit="page" to="79">79</biblScope></imprint><idno type="ISSN">0167-5273</idno></series><idno type="istex">04D7D7F767F9F3104FAC178805B6E200C1604262</idno><idno type="DOI">10.1016/0167-5273(92)90110-O</idno><idno type="PII">0167-5273(92)90110-O</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The electrophysiologic effects of pentisomide were investigated after intravenous (5 mg/kg) and oral (900–1200 mg three times a day) application in 9 patients with drug refractory atrioventricular nodal tachycardia and 6 patients with orthodromic atrioventricular re-entrant tachycardia. Pentisomide did not change sinus cycle length, effective refractory period of the right ventricle and the atrioventricular node. AH, HV interval, effective refractory period of the right atrium, QRS duration and QTc duration were (p ≤ 0.01) increased. Tachycardia cycle length was only increased after intravenous application of pentisomide, antegrade effective refractory periods of the accessory pathways and shortest fully pre-excited R-R intervals during atrial fibrillation were increased after the oral treatment phase (p = 0.054). Intravenous pentisomide prevented tachycardia in 69 patients with atrioventricular nodal tachycardia and in 26 patients with atrioventricular re-entrant tachycardia. If intravenous pentisomide did not prevent induction of the tachycardia, oral pentisomide was not effective either. During long-term follow-up 27 patients with atrioventricular nodal tachycardia and 14 patient with atrioventricular re-entrant tachycardia had a recurrence. Long-term treatment with pentisomide had to be discontinued because of possible side effects in 2 patients. It is concluded, that the electrophysiological effects of pentisomide are similar to those of flecainide and propafenone.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001022 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001022 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:04D7D7F767F9F3104FAC178805B6E200C1604262
|texte= Electrophysiology and long-term efficacy of pentisomide in patients with supraventricular tachycardia
}}
| This area was generated with Dilib version V0.6.23. |  |