The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.
Identifieur interne : 000052 ( PubMed/Corpus ); précédent : 000051; suivant : 000053The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.
Auteurs : Vincent Huin ; Vincent Deramecourt ; Dominique Caparros-Lefebvre ; Claude-Alain Maurage ; Charles Duyckaerts ; Eniko Kovari ; Florence Pasquier ; Valérie Buée-Scherrer ; Julien Labreuche ; Hélène Behal ; Luc Buée ; Claire-Marie Dhaenens ; Bernard SablonnièreSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes in Alzheimer's disease and Parkinson's disease brains. However, few studies examine the sequences beyond the constitutive promoter.
DOI: 10.1002/mds.26820
PubMed: 27709663
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Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Caparros Lefebvre, Dominique" sort="Caparros Lefebvre, Dominique" uniqKey="Caparros Lefebvre D" first="Dominique" last="Caparros-Lefebvre">Dominique Caparros-Lefebvre</name><affiliation><nlm:affiliation>Centre Hospitalier de Wattrelos, Service de Neurologie, Wattrelos, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maurage, Claude Alain" sort="Maurage, Claude Alain" uniqKey="Maurage C" first="Claude-Alain" last="Maurage">Claude-Alain Maurage</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation><nlm:affiliation>Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kovari, Eniko" sort="Kovari, Eniko" uniqKey="Kovari E" first="Eniko" last="Kovari">Eniko Kovari</name><affiliation><nlm:affiliation>Department of Mental Health and Psychiatry, University Hospitals and University of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, U1171 - CNR-MAJ, DISTALZ, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Buee Scherrer, Valerie" sort="Buee Scherrer, Valerie" uniqKey="Buee Scherrer V" first="Valérie" last="Buée-Scherrer">Valérie Buée-Scherrer</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Labreuche, Julien" sort="Labreuche, Julien" uniqKey="Labreuche J" first="Julien" last="Labreuche">Julien Labreuche</name><affiliation><nlm:affiliation>Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, Département de Statistiques, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Behal, Helene" sort="Behal, Helene" uniqKey="Behal H" first="Hélène" last="Behal">Hélène Behal</name><affiliation><nlm:affiliation>Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, Département de Statistiques, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buée">Luc Buée</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dhaenens, Claire Marie" sort="Dhaenens, Claire Marie" uniqKey="Dhaenens C" first="Claire-Marie" last="Dhaenens">Claire-Marie Dhaenens</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sablonniere, Bernard" sort="Sablonniere, Bernard" uniqKey="Sablonniere B" first="Bernard" last="Sablonnière">Bernard Sablonnière</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27709663</idno><idno type="pmid">27709663</idno><idno type="doi">10.1002/mds.26820</idno><idno type="wicri:Area/PubMed/Corpus">000052</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000052</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.</title><author><name sortKey="Huin, Vincent" sort="Huin, Vincent" uniqKey="Huin V" first="Vincent" last="Huin">Vincent Huin</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Deramecourt, Vincent" sort="Deramecourt, Vincent" uniqKey="Deramecourt V" first="Vincent" last="Deramecourt">Vincent Deramecourt</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Caparros Lefebvre, Dominique" sort="Caparros Lefebvre, Dominique" uniqKey="Caparros Lefebvre D" first="Dominique" last="Caparros-Lefebvre">Dominique Caparros-Lefebvre</name><affiliation><nlm:affiliation>Centre Hospitalier de Wattrelos, Service de Neurologie, Wattrelos, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maurage, Claude Alain" sort="Maurage, Claude Alain" uniqKey="Maurage C" first="Claude-Alain" last="Maurage">Claude-Alain Maurage</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name><affiliation><nlm:affiliation>Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kovari, Eniko" sort="Kovari, Eniko" uniqKey="Kovari E" first="Eniko" last="Kovari">Eniko Kovari</name><affiliation><nlm:affiliation>Department of Mental Health and Psychiatry, University Hospitals and University of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquier, Florence" sort="Pasquier, Florence" uniqKey="Pasquier F" first="Florence" last="Pasquier">Florence Pasquier</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, U1171 - CNR-MAJ, DISTALZ, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Buee Scherrer, Valerie" sort="Buee Scherrer, Valerie" uniqKey="Buee Scherrer V" first="Valérie" last="Buée-Scherrer">Valérie Buée-Scherrer</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Labreuche, Julien" sort="Labreuche, Julien" uniqKey="Labreuche J" first="Julien" last="Labreuche">Julien Labreuche</name><affiliation><nlm:affiliation>Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, Département de Statistiques, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Behal, Helene" sort="Behal, Helene" uniqKey="Behal H" first="Hélène" last="Behal">Hélène Behal</name><affiliation><nlm:affiliation>Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, Département de Statistiques, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buée">Luc Buée</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dhaenens, Claire Marie" sort="Dhaenens, Claire Marie" uniqKey="Dhaenens C" first="Claire-Marie" last="Dhaenens">Claire-Marie Dhaenens</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sablonniere, Bernard" sort="Sablonniere, Bernard" uniqKey="Sablonniere B" first="Bernard" last="Sablonnière">Bernard Sablonnière</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes in Alzheimer's disease and Parkinson's disease brains. However, few studies examine the sequences beyond the constitutive promoter.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27709663</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>06</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>The MAPT gene is differentially methylated in the progressive supranuclear palsy brain.</ArticleTitle><Pagination><MedlinePgn>1883-1890</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26820</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease causing parkinsonian symptoms. Altered DNA methylation of the microtubule-associated protein tau gene correlates with the expression changes in Alzheimer's disease and Parkinson's disease brains. However, few studies examine the sequences beyond the constitutive promoter.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Because activating different microtubule-associated protein tau gene control regions via methylation might regulate the differential tau expression constituting the specific signatures of individual tauopathies, we compared methylation of a candidate promoter, intron 0.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We assessed DNA methylation in the brains of patients with different tauopathies (35 Alzheimer's disease, 10 corticobasal degeneration, and 18 PSP) and 19 controls by intron 0 pyrosequencing. We also evaluated methylation in an independent cohort of 11 PSP cases and 12 controls. Frontal (affected by tau pathology) and occipital (unaffected) cortices were analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the initial samples, one CpG island site in intron 0 (CpG1) showed significant hypomethylation in PSP-affected frontal cortices when compared with controls (P = .022). Such hypomethylation was observed in replicate samples, but not in occipital cortices or other tauopathies. PSP and control samples (combining the initial and replicate samples) remained significantly different after adjustment for potential confounding factors (age, H1/H1 diplotype; P = .0005). PSP-affected tissues exhibited microtubule-associated protein tau RNA hyperexpression when compared with controls (P = .004), although no correlation with CpG1 methylation was observed.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This exploratory study suggests that regions other than the constitutive promoter may be involved in microtubule-associated protein tau gene regulation in tauopathies and that intron 0 hypomethylation may be a specific epigenetic signature of PSP. These preliminary findings require confirmation. © 2016 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Huin</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deramecourt</LastName><ForeName>Vincent</ForeName><Initials>V</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-8201-5406</Identifier><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caparros-Lefebvre</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centre Hospitalier de Wattrelos, Service de Neurologie, Wattrelos, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maurage</LastName><ForeName>Claude-Alain</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duyckaerts</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Laboratoire de Neuropathologie Escourolle, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kovari</LastName><ForeName>Eniko</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Mental Health and Psychiatry, University Hospitals and University of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasquier</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, U1171 - CNR-MAJ, DISTALZ, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buée-Scherrer</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labreuche</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, Département de Statistiques, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Behal</LastName><ForeName>Hélène</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Univ. Lille, CHU Lille, EA 2694 - Santé publique : épidémiologie et qualité des soins, Département de Statistiques, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buée</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dhaenens</LastName><ForeName>Claire-Marie</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sablonnière</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DNA methylation</Keyword><Keyword MajorTopicYN="N">PSP</Keyword><Keyword MajorTopicYN="N">epigenetic</Keyword><Keyword MajorTopicYN="N">microtubule-associated protein tau</Keyword><Keyword MajorTopicYN="N">tauopathy</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27709663</ArticleId><ArticleId IdType="doi">10.1002/mds.26820</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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