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Clinical and demographic characteristics related to onset site and spread of cervical dystonia.

Identifieur interne : 000051 ( PubMed/Corpus ); précédent : 000050; suivant : 000052

Clinical and demographic characteristics related to onset site and spread of cervical dystonia.

Auteurs : Scott A. Norris ; H A Jinnah ; Alberto J. Espay ; Christine Klein ; Norbert Brüggemann ; Richard L. Barbano ; Irene Andonia C. Malaty ; Ramon L. Rodriguez ; Marie Vidailhet ; Emmanuel Roze ; Stephen G. Reich ; Brian D. Berman ; Mark S. Ledoux ; Sarah Pirio Richardson ; Pinky Agarwal ; Zoltan Mari ; William G. Ondo ; Ludy C. Shih ; Susan H. Fox ; Alfredo Berardelli ; Claudia M. Testa ; Florence Ching-Fen Cheng ; Daniel Truong ; Fatta B. Nahab ; Tao Xie ; Mark Hallett ; Ami R. Rosen ; Laura J. Wright ; Joel S. Perlmutter

Source :

RBID : pubmed:27753188

Abstract

Clinical characteristics of isolated idiopathic cervical dystonia such as onset site and spread to and from additional body regions have been addressed in single-site studies with limited data and incomplete or variable dissociation of focal and segmental subtypes. The objectives of this study were to characterize the clinical characteristics and demographics of isolated idiopathic cervical dystonia in the largest standardized multicenter cohort.

DOI: 10.1002/mds.26817
PubMed: 27753188

Links to Exploration step

pubmed:27753188

Le document en format XML

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<nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation>
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<name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name>
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<name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
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<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
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<nlm:affiliation>Institute of Neurogenetics and Department of Neurology, University of Luebeck, Luebeck, Germany.</nlm:affiliation>
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<name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name>
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<name sortKey="Barbano, Richard L" sort="Barbano, Richard L" uniqKey="Barbano R" first="Richard L" last="Barbano">Richard L. Barbano</name>
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<nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York, USA.</nlm:affiliation>
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<name sortKey="Malaty, Irene Andonia C" sort="Malaty, Irene Andonia C" uniqKey="Malaty I" first="Irene Andonia C" last="Malaty">Irene Andonia C. Malaty</name>
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<name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L" last="Rodriguez">Ramon L. Rodriguez</name>
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<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
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<name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
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<name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G" last="Reich">Stephen G. Reich</name>
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<name sortKey="Berman, Brian D" sort="Berman, Brian D" uniqKey="Berman B" first="Brian D" last="Berman">Brian D. Berman</name>
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<nlm:affiliation>Department of Neurology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.</nlm:affiliation>
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<name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S" last="Ledoux">Mark S. Ledoux</name>
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<nlm:affiliation>Departments of Neurology and Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.</nlm:affiliation>
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<name sortKey="Richardson, Sarah Pirio" sort="Richardson, Sarah Pirio" uniqKey="Richardson S" first="Sarah Pirio" last="Richardson">Sarah Pirio Richardson</name>
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<nlm:affiliation>Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.</nlm:affiliation>
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<name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name>
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<name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
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<name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G" last="Ondo">William G. Ondo</name>
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<name sortKey="Shih, Ludy C" sort="Shih, Ludy C" uniqKey="Shih L" first="Ludy C" last="Shih">Ludy C. Shih</name>
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<name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name>
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<name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
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<nlm:affiliation>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed, Italy.</nlm:affiliation>
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<name sortKey="Testa, Claudia M" sort="Testa, Claudia M" uniqKey="Testa C" first="Claudia M" last="Testa">Claudia M. Testa</name>
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<nlm:affiliation>Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA.</nlm:affiliation>
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<name sortKey="Cheng, Florence Ching Fen" sort="Cheng, Florence Ching Fen" uniqKey="Cheng F" first="Florence Ching-Fen" last="Cheng">Florence Ching-Fen Cheng</name>
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<name sortKey="Xie, Tao" sort="Xie, Tao" uniqKey="Xie T" first="Tao" last="Xie">Tao Xie</name>
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<title xml:lang="en">Clinical and demographic characteristics related to onset site and spread of cervical dystonia.</title>
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<name sortKey="Norris, Scott A" sort="Norris, Scott A" uniqKey="Norris S" first="Scott A" last="Norris">Scott A. Norris</name>
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<nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation>
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<name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name>
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<nlm:affiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
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<nlm:affiliation>James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
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<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation>
<nlm:affiliation>Institute of Neurogenetics and Department of Neurology, University of Luebeck, Luebeck, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Bruggemann, Norbert" sort="Bruggemann, Norbert" uniqKey="Bruggemann N" first="Norbert" last="Brüggemann">Norbert Brüggemann</name>
<affiliation>
<nlm:affiliation>Institute of Neurogenetics and Department of Neurology, University of Luebeck, Luebeck, Germany.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Barbano, Richard L" sort="Barbano, Richard L" uniqKey="Barbano R" first="Richard L" last="Barbano">Richard L. Barbano</name>
<affiliation>
<nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Malaty, Irene Andonia C" sort="Malaty, Irene Andonia C" uniqKey="Malaty I" first="Irene Andonia C" last="Malaty">Irene Andonia C. Malaty</name>
<affiliation>
<nlm:affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rodriguez, Ramon L" sort="Rodriguez, Ramon L" uniqKey="Rodriguez R" first="Ramon L" last="Rodriguez">Ramon L. Rodriguez</name>
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<nlm:affiliation>Department of Neurology, University of Florida, Gainesville, Florida, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name>
<affiliation>
<nlm:affiliation>Hôpital Universitaire Pitié-Salpêtrière, Sorbonne Universités, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Roze, Emmanuel" sort="Roze, Emmanuel" uniqKey="Roze E" first="Emmanuel" last="Roze">Emmanuel Roze</name>
<affiliation>
<nlm:affiliation>Hôpital Universitaire Pitié-Salpêtrière, Sorbonne Universités, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Reich, Stephen G" sort="Reich, Stephen G" uniqKey="Reich S" first="Stephen G" last="Reich">Stephen G. Reich</name>
<affiliation>
<nlm:affiliation>Department of Neurology, University of Maryland, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Berman, Brian D" sort="Berman, Brian D" uniqKey="Berman B" first="Brian D" last="Berman">Brian D. Berman</name>
<affiliation>
<nlm:affiliation>Department of Neurology, University of Colorado Denver School of Medicine, Aurora, Colorado, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S" last="Ledoux">Mark S. Ledoux</name>
<affiliation>
<nlm:affiliation>Departments of Neurology and Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Richardson, Sarah Pirio" sort="Richardson, Sarah Pirio" uniqKey="Richardson S" first="Sarah Pirio" last="Richardson">Sarah Pirio Richardson</name>
<affiliation>
<nlm:affiliation>Department of Neurology, University of New Mexico, Albuquerque, New Mexico, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Agarwal, Pinky" sort="Agarwal, Pinky" uniqKey="Agarwal P" first="Pinky" last="Agarwal">Pinky Agarwal</name>
<affiliation>
<nlm:affiliation>Booth Gardner Parkinson's Care Center, Kirkland, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ondo, William G" sort="Ondo, William G" uniqKey="Ondo W" first="William G" last="Ondo">William G. Ondo</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Houston Methodist, Houston Texas, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Shih, Ludy C" sort="Shih, Ludy C" uniqKey="Shih L" first="Ludy C" last="Shih">Ludy C. Shih</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name>
<affiliation>
<nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name>
<affiliation>
<nlm:affiliation>Department of Neurology and Psychiatry, Sapienza University of Rome and IRCCS Neuromed, Italy.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Testa, Claudia M" sort="Testa, Claudia M" uniqKey="Testa C" first="Claudia M" last="Testa">Claudia M. Testa</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Cheng, Florence Ching Fen" sort="Cheng, Florence Ching Fen" uniqKey="Cheng F" first="Florence Ching-Fen" last="Cheng">Florence Ching-Fen Cheng</name>
<affiliation>
<nlm:affiliation>Neurology Department, West-mead Hospital, Westmead, Australia.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Truong, Daniel" sort="Truong, Daniel" uniqKey="Truong D" first="Daniel" last="Truong">Daniel Truong</name>
<affiliation>
<nlm:affiliation>The Parkinson and Movement Disorder Institute, Fountain Valley, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Nahab, Fatta B" sort="Nahab, Fatta B" uniqKey="Nahab F" first="Fatta B" last="Nahab">Fatta B. Nahab</name>
<affiliation>
<nlm:affiliation>Department of Neurosciences, University of California, San Diego, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Xie, Tao" sort="Xie, Tao" uniqKey="Xie T" first="Tao" last="Xie">Tao Xie</name>
<affiliation>
<nlm:affiliation>Department of Neurology, University of Chicago Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Hallett, Mark" sort="Hallett, Mark" uniqKey="Hallett M" first="Mark" last="Hallett">Mark Hallett</name>
<affiliation>
<nlm:affiliation>Human Motor Control Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Rosen, Ami R" sort="Rosen, Ami R" uniqKey="Rosen A" first="Ami R" last="Rosen">Ami R. Rosen</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Emory University, Atlanta, Georgia, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Wright, Laura J" sort="Wright, Laura J" uniqKey="Wright L" first="Laura J" last="Wright">Laura J. Wright</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S" last="Perlmutter">Joel S. Perlmutter</name>
<affiliation>
<nlm:affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint>
<date when="2016" type="published">2016</date>
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<div type="abstract" xml:lang="en">Clinical characteristics of isolated idiopathic cervical dystonia such as onset site and spread to and from additional body regions have been addressed in single-site studies with limited data and incomplete or variable dissociation of focal and segmental subtypes. The objectives of this study were to characterize the clinical characteristics and demographics of isolated idiopathic cervical dystonia in the largest standardized multicenter cohort.</div>
</front>
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<PMID Version="1">27753188</PMID>
<DateCreated>
<Year>2016</Year>
<Month>10</Month>
<Day>18</Day>
</DateCreated>
<DateRevised>
<Year>2016</Year>
<Month>12</Month>
<Day>15</Day>
</DateRevised>
<Article PubModel="Print-Electronic">
<Journal>
<ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>31</Volume>
<Issue>12</Issue>
<PubDate>
<Year>2016</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Clinical and demographic characteristics related to onset site and spread of cervical dystonia.</ArticleTitle>
<Pagination>
<MedlinePgn>1874-1882</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26817</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Clinical characteristics of isolated idiopathic cervical dystonia such as onset site and spread to and from additional body regions have been addressed in single-site studies with limited data and incomplete or variable dissociation of focal and segmental subtypes. The objectives of this study were to characterize the clinical characteristics and demographics of isolated idiopathic cervical dystonia in the largest standardized multicenter cohort.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The Dystonia Coalition, through a consortium of 37 recruiting sites in North America, Europe, and Australia, recruited 1477 participants with focal (60.7%) or segmental (39.3%) cervical dystonia on examination. Clinical and demographic characteristics were evaluated in terms of the body region of dystonia onset and spread.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Site of dystonia onset was: (1) focal neck only (78.5%), (2) focal onset elsewhere with later segmental spread to neck (13.3%), and (3) segmental onset with initial neck involvement (8.2%). Frequency of spread from focal cervical to segmental dystonia (22.8%) was consistent with prior reports, but frequency of segmental onset with initial neck involvement was substantially higher than the 3% previously reported. Cervical dystonia with focal neck onset, more than other subtypes, was associated with spread and tremor of any type. Sensory tricks were less frequent in cervical dystonia with segmental components, and segmental cervical onset occurred at an older age.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Subgroups had modest but significant differences in the clinical characteristics that may represent different clinical entities or pathophysiologic subtypes. These findings are critical for design and implementation of studies to describe, treat, or modify disease progression in idiopathic isolated cervical dystonia. © 2016 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Norris</LastName>
<ForeName>Scott A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo>
<Affiliation>Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Jinnah</LastName>
<ForeName>H A</ForeName>
<Initials>HA</Initials>
<AffiliationInfo>
<Affiliation>Departments of Neurology and Human Genetics, Emory University, Atlanta, Georgia, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Espay</LastName>
<ForeName>Alberto J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo>
<Affiliation>James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, Ohio, USA.</Affiliation>
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