Freezing/festination during motor tasks in early-stage Parkinson's disease: A prospective study.
Identifieur interne : 000053 ( PubMed/Corpus ); précédent : 000052; suivant : 000054Freezing/festination during motor tasks in early-stage Parkinson's disease: A prospective study.
Auteurs : Arnaud Delval ; Mélanie Rambour ; Céline Tard ; Kathy Dujardin ; David Devos ; Séverine Bleuse ; Luc Defebvre ; Caroline MoreauSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
Parkinsonian patients have a tendency to speed up during repetitive motor tasks (festination) and to experience sudden motor blocks (freezing). In this article, we prospectively studied the appearance and progression of these phenomena in 30 early-stage PD patients.
DOI: 10.1002/mds.26762
PubMed: 27618808
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Freezing/festination during motor tasks in early-stage Parkinson's disease: A prospective study.</title><author><name sortKey="Delval, Arnaud" sort="Delval, Arnaud" uniqKey="Delval A" first="Arnaud" last="Delval">Arnaud Delval</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rambour, Melanie" sort="Rambour, Melanie" uniqKey="Rambour M" first="Mélanie" last="Rambour">Mélanie Rambour</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tard, Celine" sort="Tard, Celine" uniqKey="Tard C" first="Céline" last="Tard">Céline Tard</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bleuse, Severine" sort="Bleuse, Severine" uniqKey="Bleuse S" first="Séverine" last="Bleuse">Séverine Bleuse</name><affiliation><nlm:affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27618808</idno><idno type="pmid">27618808</idno><idno type="doi">10.1002/mds.26762</idno><idno type="wicri:Area/PubMed/Corpus">000053</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000053</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Freezing/festination during motor tasks in early-stage Parkinson's disease: A prospective study.</title><author><name sortKey="Delval, Arnaud" sort="Delval, Arnaud" uniqKey="Delval A" first="Arnaud" last="Delval">Arnaud Delval</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rambour, Melanie" sort="Rambour, Melanie" uniqKey="Rambour M" first="Mélanie" last="Rambour">Mélanie Rambour</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tard, Celine" sort="Tard, Celine" uniqKey="Tard C" first="Céline" last="Tard">Céline Tard</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Devos, David" sort="Devos, David" uniqKey="Devos D" first="David" last="Devos">David Devos</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bleuse, Severine" sort="Bleuse, Severine" uniqKey="Bleuse S" first="Séverine" last="Bleuse">Séverine Bleuse</name><affiliation><nlm:affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Moreau, Caroline" sort="Moreau, Caroline" uniqKey="Moreau C" first="Caroline" last="Moreau">Caroline Moreau</name><affiliation><nlm:affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinsonian patients have a tendency to speed up during repetitive motor tasks (festination) and to experience sudden motor blocks (freezing). In this article, we prospectively studied the appearance and progression of these phenomena in 30 early-stage PD patients.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27618808</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>13</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Freezing/festination during motor tasks in early-stage Parkinson's disease: A prospective study.</ArticleTitle><Pagination><MedlinePgn>1837-1845</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26762</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Parkinsonian patients have a tendency to speed up during repetitive motor tasks (festination) and to experience sudden motor blocks (freezing). In this article, we prospectively studied the appearance and progression of these phenomena in 30 early-stage PD patients.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 30 controls and early-stage PD patients were assessed in the "off-drug" condition at baseline and 2 years later. Freezing of gait was evaluated using a standardized gait trajectory with the usual triggers. Patients also performed diadochokinetic tasks with 3 different effectors (repetitive, antiphase movements for the hands and feet, and repetitive syllable production for the orofacial effector) at frequencies ranging from 1 to 7 Hz (in random order). The primary endpoint was the occurrence of freezing and festination.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At baseline, freezing was observed in 6.5% of the trials in PD patients (43% of the patients) and 2.3% of the trials in controls, and festination was observed in 5.7% of the trials in patients (53% of the patients) and 0.8% of the trials in controls. These proportions were slightly higher in patients 2 years later. None of the patients presented freezing of gait at baseline, but 2 displayed this condition 2 years later. These phenomena occurred more frequently for the limb effectors than for the orofacial effector. Freezing and festination were associated with the akinetic-rigid subtype, although tremor-dominant patients displayed greater rhythm variability outside episodes.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Freezing and festination of the upper and lower limbs are observed soon after the diagnosis of PD and may be early biomarkers for disease progression. © 2016 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Delval</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurophysiologie Clinique-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rambour</LastName><ForeName>Mélanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tard</LastName><ForeName>Céline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurophysiologie Clinique-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille cedex, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dujardin</LastName><ForeName>Kathy</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devos</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bleuse</LastName><ForeName>Séverine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moreau</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université de Lille, INSERM U1171-Troubles cognitifs dégénératifs et vasculaires, Lille, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Neurologie-Centre Hospitalier Régional Universitaire de Lille, Département d'analyse du mouvement, Lille University, Lille cedex, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>09</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Festination</Keyword><Keyword MajorTopicYN="N">Freezing</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">Rhythmicity</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>03</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>07</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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