ParkinsonFranceV1, PascalFrancis, Curation, bibRecord, 000F51

Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION

Identifieur interne : 000F51 ( PascalFrancis/Curation ); précédent : 000F50; suivant : 000F52

Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION

Auteurs : Delphine Michel-Monigadon [France] ; Virginie Bonnamain [France] ; Veronique Nerriere-Daguin [France] ; Anne-Sophie Dugast [France] ; Xavier Leveque [France] ; Martine Plat [France] ; Eric Venturi [France] ; Philippe Brachet [France] ; Ignacio Anegon [France] ; Bernard Vanhove [France] ; Isabelle Neveu [France] ; Philippe Naveilhan [France]

Source :

Experimental neurology : (Print) [ 0014-4886 ] ; 2011.

RBID : Pascal:11-0311818

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Précurseur, Encéphale, Intracérébral, Transplantation, Croissance, Réparation, Immunodépression, Greffon, Rejet, Cellule souche, Lymphocyte T.
Wicri :
- topic : Cellule souche.

English descriptors

KwdEn :
- Encephalon, Graft(material), Growth, Immunosuppression, Intracerebral, Nervous system diseases, Parkinson disease, Precursor, Rejection, Repair, Stem cell, T-Lymphocyte, Transplantation.

Abstract

Intracerebral xenotransplantation of porcine fetal neuroblasts (pNB) is considered as an alternative to human neuroblasts for the treatment of neurodegenerative diseases. However, pNB are systematically rejected, even in an immunoprivileged site such as the brain. Within this context, neural stem/precursor cells (NSPC), which were suggested as exhibiting low immunogenicity, appeared as a useful source of xenogeneic cells. To determine the advantage of using porcine NSPC (pNSPC) in xenotransplantation, pNB and pNSPC were grafted into the striatum of rats without immunosuppression. At day 63, all the pNB were rejected while 40% of the rats transplanted with pNSPC exhibited large and healthy grafts with numerous pNF70-positive cells. The absence of inflammation at day 63 and the occasional presence of T cells in pNSPC grafts evoked a weak host immune response which might be partly due to the immunosuppressive properties of the transplanted cells. T cell proliferation assays confirmed such a hypothesis by revealing an inhibitory effect of pNSPC on T cells through a soluble factor. In addition to their immunosuppressive effect, in contrast to pNB, very few pNSPC differentiated into tyrosine hydroxylase-positive neurons but the cells triggered an intense innervation of the striatum by rat dopaminergic fibers coming from the substantia nigra. Further experiments will be required to optimize the use of pNSPC in regenerative medicine but here we show that their immunomodulatory and trophic activities might be of great interest for restorative strategies. This article is part of a Special Issue entitled "Interaction between repair, disease, & inflammation.".

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C01	`01`		`ENG`	@0 Intracerebral xenotransplantation of porcine fetal neuroblasts (pNB) is considered as an alternative to human neuroblasts for the treatment of neurodegenerative diseases. However, pNB are systematically rejected, even in an immunoprivileged site such as the brain. Within this context, neural stem/precursor cells (NSPC), which were suggested as exhibiting low immunogenicity, appeared as a useful source of xenogeneic cells. To determine the advantage of using porcine NSPC (pNSPC) in xenotransplantation, pNB and pNSPC were grafted into the striatum of rats without immunosuppression. At day 63, all the pNB were rejected while 40% of the rats transplanted with pNSPC exhibited large and healthy grafts with numerous pNF70-positive cells. The absence of inflammation at day 63 and the occasional presence of T cells in pNSPC grafts evoked a weak host immune response which might be partly due to the immunosuppressive properties of the transplanted cells. T cell proliferation assays confirmed such a hypothesis by revealing an inhibitory effect of pNSPC on T cells through a soluble factor. In addition to their immunosuppressive effect, in contrast to pNB, very few pNSPC differentiated into tyrosine hydroxylase-positive neurons but the cells triggered an intense innervation of the striatum by rat dopaminergic fibers coming from the substantia nigra. Further experiments will be required to optimize the use of pNSPC in regenerative medicine but here we show that their immunomodulatory and trophic activities might be of great interest for restorative strategies. This article is part of a Special Issue entitled "Interaction between repair, disease, & inflammation.".
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Pascal:11-0311818

Le document en format XML

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<author><name sortKey="Anegon, Ignacio" sort="Anegon, Ignacio" uniqKey="Anegon I" first="Ignacio" last="Anegon">Ignacio Anegon</name>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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<author><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
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<author><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name>
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<author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name>
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</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0311818</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0311818 INIST</idno>
<idno type="RBID">Pascal:11-0311818</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000388</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION</title>
<author><name sortKey="Michel Monigadon, Delphine" sort="Michel Monigadon, Delphine" uniqKey="Michel Monigadon D" first="Delphine" last="Michel-Monigadon">Delphine Michel-Monigadon</name>
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<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
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</author>
<author><name sortKey="Bonnamain, Virginie" sort="Bonnamain, Virginie" uniqKey="Bonnamain V" first="Virginie" last="Bonnamain">Virginie Bonnamain</name>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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</author>
<author><name sortKey="Nerriere Daguin, Veronique" sort="Nerriere Daguin, Veronique" uniqKey="Nerriere Daguin V" first="Veronique" last="Nerriere-Daguin">Veronique Nerriere-Daguin</name>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
<s2>Nantes</s2>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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</affiliation>
</author>
<author><name sortKey="Dugast, Anne Sophie" sort="Dugast, Anne Sophie" uniqKey="Dugast A" first="Anne-Sophie" last="Dugast">Anne-Sophie Dugast</name>
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<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
<s2>Nantes</s2>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Leveque, Xavier" sort="Leveque, Xavier" uniqKey="Leveque X" first="Xavier" last="Leveque">Xavier Leveque</name>
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<s2>Nantes</s2>
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<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
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</affiliation>
</author>
<author><name sortKey="Plat, Martine" sort="Plat, Martine" uniqKey="Plat M" first="Martine" last="Plat">Martine Plat</name>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Venturi, Eric" sort="Venturi, Eric" uniqKey="Venturi E" first="Eric" last="Venturi">Eric Venturi</name>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Brachet, Philippe" sort="Brachet, Philippe" uniqKey="Brachet P" first="Philippe" last="Brachet">Philippe Brachet</name>
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</affiliation>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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</affiliation>
</author>
<author><name sortKey="Anegon, Ignacio" sort="Anegon, Ignacio" uniqKey="Anegon I" first="Ignacio" last="Anegon">Ignacio Anegon</name>
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</affiliation>
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<sZ>12 aut.</sZ>
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<author><name sortKey="Vanhove, Bernard" sort="Vanhove, Bernard" uniqKey="Vanhove B" first="Bernard" last="Vanhove">Bernard Vanhove</name>
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<sZ>12 aut.</sZ>
</inist:fA14>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>12 aut.</sZ>
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</affiliation>
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<author><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, UMR643</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
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<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
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<sZ>11 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM, UMR643</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
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<country>France</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Experimental neurology : (Print)</title>
<title level="j" type="abbreviated">Exp. neurol. : (Print)</title>
<idno type="ISSN">0014-4886</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Experimental neurology : (Print)</title>
<title level="j" type="abbreviated">Exp. neurol. : (Print)</title>
<idno type="ISSN">0014-4886</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Encephalon</term>
<term>Graft(material)</term>
<term>Growth</term>
<term>Immunosuppression</term>
<term>Intracerebral</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Precursor</term>
<term>Rejection</term>
<term>Repair</term>
<term>Stem cell</term>
<term>T-Lymphocyte</term>
<term>Transplantation</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Précurseur</term>
<term>Encéphale</term>
<term>Intracérébral</term>
<term>Transplantation</term>
<term>Croissance</term>
<term>Réparation</term>
<term>Immunodépression</term>
<term>Greffon</term>
<term>Rejet</term>
<term>Cellule souche</term>
<term>Lymphocyte T</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Cellule souche</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Intracerebral xenotransplantation of porcine fetal neuroblasts (pNB) is considered as an alternative to human neuroblasts for the treatment of neurodegenerative diseases. However, pNB are systematically rejected, even in an immunoprivileged site such as the brain. Within this context, neural stem/precursor cells (NSPC), which were suggested as exhibiting low immunogenicity, appeared as a useful source of xenogeneic cells. To determine the advantage of using porcine NSPC (pNSPC) in xenotransplantation, pNB and pNSPC were grafted into the striatum of rats without immunosuppression. At day 63, all the pNB were rejected while 40% of the rats transplanted with pNSPC exhibited large and healthy grafts with numerous pNF70-positive cells. The absence of inflammation at day 63 and the occasional presence of T cells in pNSPC grafts evoked a weak host immune response which might be partly due to the immunosuppressive properties of the transplanted cells. T cell proliferation assays confirmed such a hypothesis by revealing an inhibitory effect of pNSPC on T cells through a soluble factor. In addition to their immunosuppressive effect, in contrast to pNB, very few pNSPC differentiated into tyrosine hydroxylase-positive neurons but the cells triggered an intense innervation of the striatum by rat dopaminergic fibers coming from the substantia nigra. Further experiments will be required to optimize the use of pNSPC in regenerative medicine but here we show that their immunomodulatory and trophic activities might be of great interest for restorative strategies. This article is part of a Special Issue entitled "Interaction between repair, disease, & inflammation.".</div>
</front>
</TEI>
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<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>MICHEL-MONIGADON (Delphine)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BONNAMAIN (Virginie)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>NERRIERE-DAGUIN (Veronique)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>DUGAST (Anne-Sophie)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LEVEQUE (Xavier)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>PLAT (Martine)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>VENTURI (Eric)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>BRACHET (Philippe)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>ANEGON (Ignacio)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>VANHOVE (Bernard)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>NEVEU (Isabelle)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>NAVEILHAN (Philippe)</s1>
</fA11>
<fA14 i1="01"><s1>INSERM, UMR643</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>CHU de Nantes, ITERT</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Universite de Nantes, UFR de Medicine</s1>
<s2>Nantes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>INRA, UMR85 INRA-CNRS-Université de TOURS-Haras Nationaux, P.R.C</s1>
<s2>Nouzilly</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>I.N.R.A., UEPAO</s1>
<s2>Nouzilly</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
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<fA20><s1>35-47</s1>
</fA20>
<fA21><s1>2011</s1>
</fA21>
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</fA23>
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<s2>9181</s2>
<s5>354000190428950040</s5>
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<fA44><s0>0000</s0>
<s1>© 2011 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>1 p.1/4</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>11-0311818</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Experimental neurology : (Print)</s0>
</fA64>
<fA66 i1="01"><s0>NLD</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Intracerebral xenotransplantation of porcine fetal neuroblasts (pNB) is considered as an alternative to human neuroblasts for the treatment of neurodegenerative diseases. However, pNB are systematically rejected, even in an immunoprivileged site such as the brain. Within this context, neural stem/precursor cells (NSPC), which were suggested as exhibiting low immunogenicity, appeared as a useful source of xenogeneic cells. To determine the advantage of using porcine NSPC (pNSPC) in xenotransplantation, pNB and pNSPC were grafted into the striatum of rats without immunosuppression. At day 63, all the pNB were rejected while 40% of the rats transplanted with pNSPC exhibited large and healthy grafts with numerous pNF70-positive cells. The absence of inflammation at day 63 and the occasional presence of T cells in pNSPC grafts evoked a weak host immune response which might be partly due to the immunosuppressive properties of the transplanted cells. T cell proliferation assays confirmed such a hypothesis by revealing an inhibitory effect of pNSPC on T cells through a soluble factor. In addition to their immunosuppressive effect, in contrast to pNB, very few pNSPC differentiated into tyrosine hydroxylase-positive neurons but the cells triggered an intense innervation of the striatum by rat dopaminergic fibers coming from the substantia nigra. Further experiments will be required to optimize the use of pNSPC in regenerative medicine but here we show that their immunomodulatory and trophic activities might be of great interest for restorative strategies. This article is part of a Special Issue entitled "Interaction between repair, disease, & inflammation.".</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A25L</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Précurseur</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Precursor</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Precursor</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Intracérébral</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Intracerebral</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Intracerebral</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Transplantation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Transplantation</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Trasplantación</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Croissance</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Growth</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Crecimiento</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Réparation</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Repair</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Reparación</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Immunodépression</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Immunosuppression</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Inmunodepresión</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Greffon</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Graft(material)</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Injerto(material)</s0>
<s5>16</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Rejet</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Rejection</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Rechazo</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Cellule souche</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Stem cell</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Célula primitiva</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Lymphocyte T</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>T-Lymphocyte</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Linfocito T</s0>
<s5>19</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
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   |area=    ParkinsonFranceV1
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   |clé=     Pascal:11-0311818
   |texte=   Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION
}}

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION

Trophic and immunoregulatory properties of neural precursor cells: Benefit for intracerebral transplantation : INTERACTION BETWEEN REPAIR, DISEASES, INFLAMMATION

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