Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients
Identifieur interne : 001187 ( PascalFrancis/Checkpoint ); précédent : 001186; suivant : 001188Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients
Auteurs : S. Thobois [France] ; P. Dominey [France] ; J. Decety [France] ; P. Pollak [France] ; M. C. Gregoire [France] ; E. Broussolle [France]Source :
- Neuroreport : (Oxford) [ 0959-4965 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Regional cerebral blood flow (rCBF) was measured using PET and H215O in Parkinson's disease (PD) patients with predominantly right-sided akinetic-rigid symptoms and in control subjects during the execution of an externally cued motor task either with the left of the right hand. During the execution of the task with the left, non-akinctic, hand, cerebral activation in PD patients appeared similar to that of controls. Activated areas were the primary motor cortex, premotor cortex, parietal cortes and cerebellum. When the task was executed with the right, akinetic, hand cerebral activation in PD patients differed from that of controis subjects The most important change was a bilateral activation of the primary motor cortex. We conclude that overactivation at primary motor cortex is asymmeuical in hemiparkinsonian patients.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:00-0330470Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients</title><author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S." last="Thobois">S. Thobois</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and CERMEP, Neurological Hospital Pierre Wertheimer, 59 Bd Pinel</s1><s2>69003 Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dominey, P" sort="Dominey, P" uniqKey="Dominey P" first="P." last="Dominey">P. Dominey</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Cognitive Science, CNRS</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Decety, J" sort="Decety, J" uniqKey="Decety J" first="J." last="Decety">J. Decety</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U 280</s1><s2>Lyon</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Gregoire, M C" sort="Gregoire, M C" uniqKey="Gregoire M" first="M. C." last="Gregoire">M. C. Gregoire</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and CERMEP, Neurological Hospital Pierre Wertheimer, 59 Bd Pinel</s1><s2>69003 Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0330470</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0330470 INIST</idno><idno type="RBID">Pascal:00-0330470</idno><idno type="wicri:Area/PascalFrancis/Corpus">001363</idno><idno type="wicri:Area/PascalFrancis/Curation">000075</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001187</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001187</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients</title><author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S." last="Thobois">S. Thobois</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and CERMEP, Neurological Hospital Pierre Wertheimer, 59 Bd Pinel</s1><s2>69003 Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dominey, P" sort="Dominey, P" uniqKey="Dominey P" first="P." last="Dominey">P. Dominey</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Institute of Cognitive Science, CNRS</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Decety, J" sort="Decety, J" uniqKey="Decety J" first="J." last="Decety">J. Decety</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U 280</s1><s2>Lyon</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurology, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Gregoire, M C" sort="Gregoire, M C" uniqKey="Gregoire M" first="M. C." last="Gregoire">M. C. Gregoire</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Orsay</settlement></placeName></affiliation></author><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology and CERMEP, Neurological Hospital Pierre Wertheimer, 59 Bd Pinel</s1><s2>69003 Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Neuroreport : (Oxford)</title><title level="j" type="abbreviated">Neuroreport : (Oxf.)</title><idno type="ISSN">0959-4965</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuroreport : (Oxford)</title><title level="j" type="abbreviated">Neuroreport : (Oxf.)</title><idno type="ISSN">0959-4965</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term><term>Blood flow</term><term>Emission tomography</term><term>Experimental study</term><term>Human</term><term>Motor control</term><term>Motor cortex</term><term>Parkinson disease</term><term>Symmetry</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex moteur</term><term>Parkinson maladie</term><term>Débit sanguin</term><term>Tomoscintigraphie</term><term>Contrôle moteur</term><term>Akinésie</term><term>Symétrie</term><term>Etude expérimentale</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Regional cerebral blood flow (rCBF) was measured using PET and H<sub>2</sub><sup>15</sup>O in Parkinson's disease (PD) patients with predominantly right-sided akinetic-rigid symptoms and in control subjects during the execution of an externally cued motor task either with the left of the right hand. During the execution of the task with the left, non-akinctic, hand, cerebral activation in PD patients appeared similar to that of controls. Activated areas were the primary motor cortex, premotor cortex, parietal cortes and cerebellum. When the task was executed with the right, akinetic, hand cerebral activation in PD patients differed from that of controis subjects The most important change was a bilateral activation of the primary motor cortex. We conclude that overactivation at primary motor cortex is asymmeuical in hemiparkinsonian patients.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0959-4965</s0></fA01><fA03 i2="1"><s0>Neuroreport : (Oxf.)</s0></fA03><fA05><s2>11</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients</s1></fA08><fA11 i1="01" i2="1"><s1>THOBOIS (S.)</s1></fA11><fA11 i1="02" i2="1"><s1>DOMINEY (P.)</s1></fA11><fA11 i1="03" i2="1"><s1>DECETY (J.)</s1></fA11><fA11 i1="04" i2="1"><s1>POLLAK (P.)</s1></fA11><fA11 i1="05" i2="1"><s1>GREGOIRE (M. C.)</s1></fA11><fA11 i1="06" i2="1"><s1>BROUSSOLLE (E.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology and CERMEP, Neurological Hospital Pierre Wertheimer, 59 Bd Pinel</s1><s2>69003 Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Institute of Cognitive Science, CNRS</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>INSERM U 280</s1><s2>Lyon</s2><s3>FRA</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, CHU de Grenoble</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="05"><s1>Service Hospitalier Frédéric Joliot</s1><s2>Orsay</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA20><s1>785-789</s1></fA20><fA21><s1>2000</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>22534</s2><s5>354000082297010270</s5></fA43><fA44><s0>0000</s0><s1>© 2000 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>26 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>00-0330470</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neuroreport : (Oxford)</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Regional cerebral blood flow (rCBF) was measured using PET and H<sub>2</sub><sup>15</sup>O in Parkinson's disease (PD) patients with predominantly right-sided akinetic-rigid symptoms and in control subjects during the execution of an externally cued motor task either with the left of the right hand. During the execution of the task with the left, non-akinctic, hand, cerebral activation in PD patients appeared similar to that of controls. Activated areas were the primary motor cortex, premotor cortex, parietal cortes and cerebellum. When the task was executed with the right, akinetic, hand cerebral activation in PD patients differed from that of controis subjects The most important change was a bilateral activation of the primary motor cortex. We conclude that overactivation at primary motor cortex is asymmeuical in hemiparkinsonian patients.</s0></fC01><fC02 i1="01" i2="X"><s0>002A26D04</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Cortex moteur</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Motor cortex</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Corteza motora</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Débit sanguin</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Blood flow</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Flujo sanguíneo</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Tomoscintigraphie</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Emission tomography</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Tomocentelleografía</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Contrôle moteur</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Motor control</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Control motor</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Akinésie</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Akinesia</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Aquinesia</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Symétrie</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Symmetry</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Simetría</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Etude expérimentale</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Experimental study</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Estudio experimental</s0><s5>08</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0><s5>54</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Human</s0><s5>54</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0><s5>54</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Brain (vertebrata)</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>23</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>23</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>23</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Méthode mesure</s0><s5>29</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Measurement method</s0><s5>29</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Método medida</s0><s5>29</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Motricité</s0><s5>32</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Motricity</s0><s5>32</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Motricidad</s0><s5>32</s5></fC07><fN21><s1>228</s1></fN21></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Lyon</li><li>Orsay</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S." last="Thobois">S. Thobois</name></region><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><name sortKey="Decety, J" sort="Decety, J" uniqKey="Decety J" first="J." last="Decety">J. Decety</name><name sortKey="Dominey, P" sort="Dominey, P" uniqKey="Dominey P" first="P." last="Dominey">P. Dominey</name><name sortKey="Gregoire, M C" sort="Gregoire, M C" uniqKey="Gregoire M" first="M. C." last="Gregoire">M. C. Gregoire</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001187 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 001187 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:00-0330470
|texte= Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients
}}
| This area was generated with Dilib version V0.6.29. |  |