La maladie de Parkinson en France (serveur d'exploration)

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Omics analysis of mouse brain models of human diseases.

Identifieur interne : 001B63 ( Ncbi/Merge ); précédent : 001B62; suivant : 001B64

Omics analysis of mouse brain models of human diseases.

Auteurs : Véronique Paban [France] ; Béatrice Loriod [France] ; Claude Villard [France] ; Luc Buee [France] ; David Blum [France] ; Susanna Pietropaolo [France] ; Yoon H. Cho [France] ; Sylvie Gory-Faure [France] ; Elodie Mansour [France] ; Ali Gharbi [France] ; Béatrice Alescio-Lautier [France]

Source :

RBID : pubmed:27871923

English descriptors

Abstract

The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.

DOI: 10.1016/j.gene.2016.11.022
PubMed: 27871923

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Le document en format XML

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<name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name>
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<term>Brain Diseases (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Genomics (methods)</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Disorders (genetics)</term>
<term>Mental Disorders (metabolism)</term>
<term>Metabolic Networks and Pathways</term>
<term>Mice</term>
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<term>Mice, Transgenic</term>
<term>Neurodegenerative Diseases (genetics)</term>
<term>Neurodegenerative Diseases (metabolism)</term>
<term>Proteomics (methods)</term>
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<term>Brain Diseases</term>
<term>Mental Disorders</term>
<term>Neurodegenerative Diseases</term>
</keywords>
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<term>Brain Diseases</term>
<term>Mental Disorders</term>
<term>Neurodegenerative Diseases</term>
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<term>Proteomics</term>
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<term>Behavior, Animal</term>
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<div type="abstract" xml:lang="en">The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.</div>
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<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gene.2016.11.022</ELocationID>
<Abstract>
<AbstractText NlmCategory="UNASSIGNED">The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Paban</LastName>
<ForeName>Véronique</ForeName>
<Initials>V</Initials>
<AffiliationInfo>
<Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address: veronique.paban@univ-amu.fr.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Loriod</LastName>
<ForeName>Béatrice</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Villard</LastName>
<ForeName>Claude</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Buee</LastName>
<ForeName>Luc</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Blum</LastName>
<ForeName>David</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Pietropaolo</LastName>
<ForeName>Susanna</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Cho</LastName>
<ForeName>Yoon H</ForeName>
<Initials>YH</Initials>
<AffiliationInfo>
<Affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gory-Faure</LastName>
<ForeName>Sylvie</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mansour</LastName>
<ForeName>Elodie</ForeName>
<Initials>E</Initials>
<AffiliationInfo>
<Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gharbi</LastName>
<ForeName>Ali</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Alescio-Lautier</LastName>
<ForeName>Béatrice</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2016</Year>
<Month>11</Month>
<Day>18</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>Netherlands</Country>
<MedlineTA>Gene</MedlineTA>
<NlmUniqueID>7706761</NlmUniqueID>
<ISSNLinking>0378-1119</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList>
<MeshHeading>
<DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001927" MajorTopicYN="N">Brain Diseases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D053263" MajorTopicYN="N">Gene Regulatory Networks</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D023281" MajorTopicYN="N">Genomics</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D001523" MajorTopicYN="N">Mental Disorders</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D053858" MajorTopicYN="N">Metabolic Networks and Pathways</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName UI="D040901" MajorTopicYN="N">Proteomics</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">Amyloidosis</Keyword>
<Keyword MajorTopicYN="N">Autism</Keyword>
<Keyword MajorTopicYN="N">Huntington</Keyword>
<Keyword MajorTopicYN="N">Network</Keyword>
<Keyword MajorTopicYN="N">Parkinson</Keyword>
<Keyword MajorTopicYN="N">Proteomic</Keyword>
<Keyword MajorTopicYN="N">Schizophrenia</Keyword>
<Keyword MajorTopicYN="N">Tauopathy</Keyword>
<Keyword MajorTopicYN="N">Transcriptomic</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="received">
<Year>2016</Year>
<Month>09</Month>
<Day>15</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised">
<Year>2016</Year>
<Month>11</Month>
<Day>04</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted">
<Year>2016</Year>
<Month>11</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed">
<Year>2016</Year>
<Month>11</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2017</Year>
<Month>1</Month>
<Day>31</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2016</Year>
<Month>11</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">27871923</ArticleId>
<ArticleId IdType="pii">S0378-1119(16)30911-8</ArticleId>
<ArticleId IdType="doi">10.1016/j.gene.2016.11.022</ArticleId>
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</pubmed>
<affiliations>
<list>
<country>
<li>France</li>
</country>
<region>
<li>Aquitaine</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Hauts-de-France</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Aquitaine</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhône-Alpes</li>
</region>
<settlement>
<li>Bordeaux</li>
<li>Grenoble</li>
<li>Lille</li>
<li>Marseille</li>
</settlement>
<orgName>
<li>Université de Bordeaux</li>
</orgName>
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<tree>
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<region name="Provence-Alpes-Côte d'Azur">
<name sortKey="Paban, Veronique" sort="Paban, Veronique" uniqKey="Paban V" first="Véronique" last="Paban">Véronique Paban</name>
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<name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name>
<name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name>
<name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name>
<name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name>
<name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name>
<name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Faure">Sylvie Gory-Faure</name>
<name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name>
<name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name>
<name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name>
<name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
</country>
</tree>
</affiliations>
</record>

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