l-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?
Identifieur interne : 001B62 ( Ncbi/Merge ); précédent : 001B61; suivant : 001B63l-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?
Auteurs : Anna R. Carta [Italie] ; Giovanna Mulas [Italie] ; Mariza Bortolanza [Brésil] ; Terence Duarte [Brésil] ; Elisabetta Pillai [Italie] ; Gilberto Fisone [Suède] ; Rita Raisman Vozari [France] ; Elaine Del-Bel [Brésil]Source :
- The European journal of neuroscience [ 1460-9568 ] ; 2017.
Abstract
In Parkinson's disease (PD), l-DOPA therapy leads to the emergence of motor complications including l-DOPA-induced dyskinesia (LID). LID relies on a sequence of pre- and postsynaptic neuronal events, leading to abnormal corticostriatal neurotransmission and maladaptive changes in striatal projection neurons. In recent years, additional non-neuronal mechanisms have been proposed to contribute to LID. Among these mechanisms, considerable attention has been focused on l-DOPA-induced inflammatory responses. Microglia and astrocytes are the main actors in neuroinflammatory responses, and their double role at the interface between immune and neurophysiological responses is starting to be elucidated. Both microglia and astrocytes express a multitude of neurotransmitter receptors and via the release of several soluble molecules modulate synaptic function in neuronal networks. Here we review preclinical and clinical evidence of glial overactivation by l-DOPA, supporting a role of microglia and astrocytes in the development of LID. We propose that in PD, chronically and abnormally activated microglia and astrocytes lead to an aberrant neuron-glia communication, which affect synaptic activity and neuroplasticity contributing to the development of LID.
DOI: 10.1111/ejn.13482
PubMed: 27859864
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Carta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Mulas, Giovanna" sort="Mulas, Giovanna" uniqKey="Mulas G" first="Giovanna" last="Mulas">Giovanna Mulas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Bortolanza, Mariza" sort="Bortolanza, Mariza" uniqKey="Bortolanza M" first="Mariza" last="Bortolanza">Mariza Bortolanza</name><affiliation wicri:level="4"><nlm:affiliation>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. Café S/N, 14040-904, Ribeirão Preto, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. 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Café S/N, 14040-904, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author><author><name sortKey="Pillai, Elisabetta" sort="Pillai, Elisabetta" uniqKey="Pillai E" first="Elisabetta" last="Pillai">Elisabetta Pillai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari</wicri:regionArea><wicri:noRegion>Cagliari</wicri:noRegion></affiliation></author><author><name sortKey="Fisone, Gilberto" sort="Fisone, Gilberto" uniqKey="Fisone G" first="Gilberto" last="Fisone">Gilberto Fisone</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Vozari, Rita Raisman" sort="Vozari, Rita Raisman" uniqKey="Vozari R" first="Rita Raisman" last="Vozari">Rita Raisman Vozari</name><affiliation wicri:level="3"><nlm:affiliation>INSERM U 1127, CNRS UMR 7225, UPMC Univ Paris 06, UMR S 1127, Institut Du Cerveau et de La Moelle Epiniére, ICM, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 1127, CNRS UMR 7225, UPMC Univ Paris 06, UMR S 1127, Institut Du Cerveau et de La Moelle Epiniére, ICM, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Del Bel, Elaine" sort="Del Bel, Elaine" uniqKey="Del Bel E" first="Elaine" last="Del-Bel">Elaine Del-Bel</name><affiliation wicri:level="4"><nlm:affiliation>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. Café S/N, 14040-904, Ribeirão Preto, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. Café S/N, 14040-904, Ribeirão Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region><settlement type="city">São Paulo</settlement></placeName><orgName type="university">Université de São Paulo</orgName></affiliation></author></analytic><series><title level="j">The European journal of neuroscience</title><idno type="eISSN">1460-9568</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease (PD), l-DOPA therapy leads to the emergence of motor complications including l-DOPA-induced dyskinesia (LID). LID relies on a sequence of pre- and postsynaptic neuronal events, leading to abnormal corticostriatal neurotransmission and maladaptive changes in striatal projection neurons. In recent years, additional non-neuronal mechanisms have been proposed to contribute to LID. Among these mechanisms, considerable attention has been focused on l-DOPA-induced inflammatory responses. Microglia and astrocytes are the main actors in neuroinflammatory responses, and their double role at the interface between immune and neurophysiological responses is starting to be elucidated. Both microglia and astrocytes express a multitude of neurotransmitter receptors and via the release of several soluble molecules modulate synaptic function in neuronal networks. Here we review preclinical and clinical evidence of glial overactivation by l-DOPA, supporting a role of microglia and astrocytes in the development of LID. We propose that in PD, chronically and abnormally activated microglia and astrocytes lead to an aberrant neuron-glia communication, which affect synaptic activity and neuroplasticity contributing to the development of LID.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27859864</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>18</Day></DateCreated><DateRevised><Year>2017</Year><Month>01</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-9568</ISSN><JournalIssue CitedMedium="Internet"><Volume>45</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The European journal of neuroscience</Title><ISOAbbreviation>Eur. J. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>l-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?</ArticleTitle><Pagination><MedlinePgn>73-91</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ejn.13482</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">In Parkinson's disease (PD), l-DOPA therapy leads to the emergence of motor complications including l-DOPA-induced dyskinesia (LID). LID relies on a sequence of pre- and postsynaptic neuronal events, leading to abnormal corticostriatal neurotransmission and maladaptive changes in striatal projection neurons. In recent years, additional non-neuronal mechanisms have been proposed to contribute to LID. Among these mechanisms, considerable attention has been focused on l-DOPA-induced inflammatory responses. Microglia and astrocytes are the main actors in neuroinflammatory responses, and their double role at the interface between immune and neurophysiological responses is starting to be elucidated. Both microglia and astrocytes express a multitude of neurotransmitter receptors and via the release of several soluble molecules modulate synaptic function in neuronal networks. Here we review preclinical and clinical evidence of glial overactivation by l-DOPA, supporting a role of microglia and astrocytes in the development of LID. We propose that in PD, chronically and abnormally activated microglia and astrocytes lead to an aberrant neuron-glia communication, which affect synaptic activity and neuroplasticity contributing to the development of LID.</AbstractText><CopyrightInformation>© 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Carta</LastName><ForeName>Anna R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulas</LastName><ForeName>Giovanna</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bortolanza</LastName><ForeName>Mariza</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. Café S/N, 14040-904, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>USP, Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duarte</LastName><ForeName>Terence</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. Café S/N, 14040-904, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>USP, Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pillai</LastName><ForeName>Elisabetta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, S.P. N. 8, 09042, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fisone</LastName><ForeName>Gilberto</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Neuroscience, Karolinska Institutet, Retzius väg 8, 17177, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vozari</LastName><ForeName>Rita Raisman</ForeName><Initials>RR</Initials><AffiliationInfo><Affiliation>INSERM U 1127, CNRS UMR 7225, UPMC Univ Paris 06, UMR S 1127, Institut Du Cerveau et de La Moelle Epiniére, ICM, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Del-Bel</LastName><ForeName>Elaine</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>School of Odontology of Ribeirão Preto, Department of Morphology, Physiology and Basic Pathology, University of São Paulo (USP), Av. Café S/N, 14040-904, Ribeirão Preto, SP, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Review</PublicationType><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>12</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Eur J Neurosci</MedlineTA><NlmUniqueID>8918110</NlmUniqueID><ISSNLinking>0953-816X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">cytokine</Keyword><Keyword MajorTopicYN="N">inducible nitric oxide synthase</Keyword><Keyword MajorTopicYN="N">nitric oxide</Keyword><Keyword MajorTopicYN="N">tumor necrosis factor-α</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27859864</ArticleId><ArticleId IdType="doi">10.1111/ejn.13482</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li><li>France</li><li>Italie</li><li>Suède</li></country><region><li>Svealand</li><li>État de São Paulo</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Stockholm</li><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Carta, Anna R" sort="Carta, Anna R" uniqKey="Carta A" first="Anna R" last="Carta">Anna R. Carta</name></noRegion><name sortKey="Mulas, Giovanna" sort="Mulas, Giovanna" uniqKey="Mulas G" first="Giovanna" last="Mulas">Giovanna Mulas</name><name sortKey="Pillai, Elisabetta" sort="Pillai, Elisabetta" uniqKey="Pillai E" first="Elisabetta" last="Pillai">Elisabetta Pillai</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Bortolanza, Mariza" sort="Bortolanza, Mariza" uniqKey="Bortolanza M" first="Mariza" last="Bortolanza">Mariza Bortolanza</name></region><name sortKey="Del Bel, Elaine" sort="Del Bel, Elaine" uniqKey="Del Bel E" first="Elaine" last="Del-Bel">Elaine Del-Bel</name><name sortKey="Duarte, Terence" sort="Duarte, Terence" uniqKey="Duarte T" first="Terence" last="Duarte">Terence Duarte</name></country><country name="Suède"><region name="Svealand"><name sortKey="Fisone, Gilberto" sort="Fisone, Gilberto" uniqKey="Fisone G" first="Gilberto" last="Fisone">Gilberto Fisone</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Vozari, Rita Raisman" sort="Vozari, Rita Raisman" uniqKey="Vozari R" first="Rita Raisman" last="Vozari">Rita Raisman Vozari</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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