Omics analysis of mouse brain models of human diseases.
Identifieur interne : 000006 ( PubMed/Corpus ); précédent : 000005; suivant : 000007Omics analysis of mouse brain models of human diseases.
Auteurs : Véronique Paban ; Béatrice Loriod ; Claude Villard ; Luc Buee ; David Blum ; Susanna Pietropaolo ; Yoon H. Cho ; Sylvie Gory-Faure ; Elodie Mansour ; Ali Gharbi ; Béatrice Alescio-LautierSource :
- Gene [ 1879-0038 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Behavior, Animal, Brain Diseases (genetics), Brain Diseases (metabolism), Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Genomics (methods), Humans, Male, Mental Disorders (genetics), Mental Disorders (metabolism), Metabolic Networks and Pathways, Mice, Mice, Knockout, Mice, Transgenic, Neurodegenerative Diseases (genetics), Neurodegenerative Diseases (metabolism), Proteomics (methods).
- MESH :
- genetics : Brain Diseases, Mental Disorders, Neurodegenerative Diseases.
- metabolism : Brain Diseases, Mental Disorders, Neurodegenerative Diseases.
- methods : Genomics, Proteomics.
- Animals, Behavior, Animal, Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Humans, Male, Metabolic Networks and Pathways, Mice, Mice, Knockout, Mice, Transgenic.
Abstract
The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.
DOI: 10.1016/j.gene.2016.11.022
PubMed: 27871923
Links to Exploration step
pubmed:27871923Le document en format XML
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Electronic address: veronique.paban@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name><affiliation><nlm:affiliation>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name><affiliation><nlm:affiliation>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name><affiliation><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. 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Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27871923</idno><idno type="pmid">27871923</idno><idno type="doi">10.1016/j.gene.2016.11.022</idno><idno type="wicri:Area/PubMed/Corpus">000006</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000006</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Omics analysis of mouse brain models of human diseases.</title><author><name sortKey="Paban, Veronique" sort="Paban, Veronique" uniqKey="Paban V" first="Véronique" last="Paban">Véronique Paban</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address: veronique.paban@univ-amu.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name><affiliation><nlm:affiliation>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name><affiliation><nlm:affiliation>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name><affiliation><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name><affiliation><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name><affiliation><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Faure">Sylvie Gory-Faure</name><affiliation><nlm:affiliation>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name><affiliation><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Gene</title><idno type="eISSN">1879-0038</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Brain Diseases (genetics)</term><term>Brain Diseases (metabolism)</term><term>Disease Models, Animal</term><term>Gene Expression Profiling</term><term>Gene Regulatory Networks</term><term>Genomics (methods)</term><term>Humans</term><term>Male</term><term>Mental Disorders (genetics)</term><term>Mental Disorders (metabolism)</term><term>Metabolic Networks and Pathways</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Neurodegenerative Diseases (genetics)</term><term>Neurodegenerative Diseases (metabolism)</term><term>Proteomics (methods)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brain Diseases</term><term>Mental Disorders</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Diseases</term><term>Mental Disorders</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genomics</term><term>Proteomics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Disease Models, Animal</term><term>Gene Expression Profiling</term><term>Gene Regulatory Networks</term><term>Humans</term><term>Male</term><term>Metabolic Networks and Pathways</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27871923</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>22</Day></DateCreated><DateCompleted><Year>2017</Year><Month>01</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0038</ISSN><JournalIssue CitedMedium="Internet"><Volume>600</Volume><PubDate><Year>2017</Year><Month>Feb</Month><Day>05</Day></PubDate></JournalIssue><Title>Gene</Title><ISOAbbreviation>Gene</ISOAbbreviation></Journal><ArticleTitle>Omics analysis of mouse brain models of human diseases.</ArticleTitle><Pagination><MedlinePgn>90-100</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0378-1119(16)30911-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.gene.2016.11.022</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Paban</LastName><ForeName>Véronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address: veronique.paban@univ-amu.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loriod</LastName><ForeName>Béatrice</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villard</LastName><ForeName>Claude</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buee</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blum</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pietropaolo</LastName><ForeName>Susanna</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cho</LastName><ForeName>Yoon H</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gory-Faure</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansour</LastName><ForeName>Elodie</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gharbi</LastName><ForeName>Ali</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alescio-Lautier</LastName><ForeName>Béatrice</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>11</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Gene</MedlineTA><NlmUniqueID>7706761</NlmUniqueID><ISSNLinking>0378-1119</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001522" MajorTopicYN="N">Behavior, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001927" MajorTopicYN="N">Brain Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053263" MajorTopicYN="N">Gene Regulatory Networks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023281" MajorTopicYN="N">Genomics</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001523" MajorTopicYN="N">Mental Disorders</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053858" MajorTopicYN="N">Metabolic Networks and Pathways</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008822" MajorTopicYN="N">Mice, Transgenic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D040901" MajorTopicYN="N">Proteomics</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Amyloidosis</Keyword><Keyword MajorTopicYN="N">Autism</Keyword><Keyword MajorTopicYN="N">Huntington</Keyword><Keyword MajorTopicYN="N">Network</Keyword><Keyword MajorTopicYN="N">Parkinson</Keyword><Keyword MajorTopicYN="N">Proteomic</Keyword><Keyword MajorTopicYN="N">Schizophrenia</Keyword><Keyword MajorTopicYN="N">Tauopathy</Keyword><Keyword MajorTopicYN="N">Transcriptomic</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>11</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27871923</ArticleId><ArticleId 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