Distinct effects of dopamine vs STN stimulation therapies in associative learning and retention in Parkinson disease.
Identifieur interne : 001920 ( Ncbi/Curation ); précédent : 001919; suivant : 001921Distinct effects of dopamine vs STN stimulation therapies in associative learning and retention in Parkinson disease.
Auteurs : Jocelyne Ventre-Dominey [France] ; Hélène Mollion [France] ; Stephane Thobois [France] ; Emmanuel Broussolle [France]Source :
- Behavioural brain research [ 1872-7549 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Association Learning (physiology), Deep Brain Stimulation, Disability Evaluation, Dopamine (metabolism), Dopamine Agents (therapeutic use), Female, Humans, Learning Disorders (etiology), Learning Disorders (therapy), Levodopa (therapeutic use), Male, Maze Learning (drug effects), Maze Learning (physiology), Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Photic Stimulation, Reaction Time (drug effects), Reaction Time (physiology), Retention (Psychology) (physiology), Subthalamic Nucleus (physiology), Time Factors.
- MESH :
- chemical , metabolism : Dopamine.
- complications : Parkinson Disease.
- drug effects : Maze Learning, Reaction Time.
- etiology : Learning Disorders.
- physiology : Association Learning, Maze Learning, Reaction Time, Retention (Psychology), Subthalamic Nucleus.
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- therapy : Learning Disorders.
- Adult, Aged, Deep Brain Stimulation, Disability Evaluation, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Photic Stimulation, Time Factors.
Abstract
Evidence has been provided in Parkinson's disease patients of cognitive impairments including visual memory and learning which can be partially compensated by dopamine medication or subthalamic nucleus stimulation. The effects of these two therapies can differ according to the learning processes involving the dorsal vs ventral part of the striatum. Here we aimed to investigate and compare the outcomes of dopamine vs stimulation treatment in Parkinson patient's ability to acquire and maintain over successive days their performance in visual working memory. Parkinson patients performed conditional associative learning embedded in visual (spatial and non spatial) working memory tasks over two consecutive days either ON or OFF dopaminergic drugs or STN stimulation depending on the group of patients studied. While Parkinson patients were more accurate and faster in memory tasks ON vs OFF stimulation independent of the day of testing, performance in medicated patients differed depending on the medication status during the initial task acquisition. Patients who learnt the task ON medication the first day were able to maintain or even improve their memory performance both OFF and ON medication on the second day after consolidation. These effects were observed only in patients with dopamine replacement with or without motor fluctuations. This enhancement in memory performance after having learnt under dopamine medication and not under STN stimulation was mostly significant in visuo-spatial working memory tasks suggesting that dopamine replacement in the depleted dorsal striatum is essential for retention and consolidation of learnt skill.
DOI: 10.1016/j.bbr.2016.01.010
PubMed: 26778783
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000162
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000162
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000162
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001920
Links to Exploration step
pubmed:26778783Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct effects of dopamine vs STN stimulation therapies in associative learning and retention in Parkinson disease.</title>
<author><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM Stem Cell and Brain Research Institute U846, Bron, France; Université Lyon 1, Lyon, France. Electronic address: Jocelyne.ventre-dominey@inserm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Stem Cell and Brain Research Institute U846, Bron, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Hopital Neurologique, Centre Mémoire Ressources Recherche, Lyon, France; Université Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Hopital Neurologique, Centre Mémoire Ressources Recherche, Lyon, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stephane" last="Thobois">Stephane Thobois</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26778783</idno>
<idno type="pmid">26778783</idno>
<idno type="doi">10.1016/j.bbr.2016.01.010</idno>
<idno type="wicri:Area/PubMed/Corpus">000162</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000162</idno>
<idno type="wicri:Area/PubMed/Curation">000162</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000162</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000162</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000162</idno>
<idno type="wicri:Area/Ncbi/Merge">001920</idno>
<idno type="wicri:Area/Ncbi/Curation">001920</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Distinct effects of dopamine vs STN stimulation therapies in associative learning and retention in Parkinson disease.</title>
<author><name sortKey="Ventre Dominey, Jocelyne" sort="Ventre Dominey, Jocelyne" uniqKey="Ventre Dominey J" first="Jocelyne" last="Ventre-Dominey">Jocelyne Ventre-Dominey</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM Stem Cell and Brain Research Institute U846, Bron, France; Université Lyon 1, Lyon, France. Electronic address: Jocelyne.ventre-dominey@inserm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Stem Cell and Brain Research Institute U846, Bron, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mollion, Helene" sort="Mollion, Helene" uniqKey="Mollion H" first="Hélène" last="Mollion">Hélène Mollion</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Hopital Neurologique, Centre Mémoire Ressources Recherche, Lyon, France; Université Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Hopital Neurologique, Centre Mémoire Ressources Recherche, Lyon, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stephane" last="Thobois">Stephane Thobois</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
<affiliation wicri:level="3"><nlm:affiliation>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hospices Civils de Lyon, Hopital Neurologique, Neurologie C, Lyon, France; CNRS, Centre de Neurosciences Cognitives, UMR 5229, Bron, France; Université Lyon 1, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Behavioural brain research</title>
<idno type="eISSN">1872-7549</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Association Learning (physiology)</term>
<term>Deep Brain Stimulation</term>
<term>Disability Evaluation</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Agents (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Learning Disorders (etiology)</term>
<term>Learning Disorders (therapy)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Maze Learning (drug effects)</term>
<term>Maze Learning (physiology)</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Photic Stimulation</term>
<term>Reaction Time (drug effects)</term>
<term>Reaction Time (physiology)</term>
<term>Retention (Psychology) (physiology)</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Maze Learning</term>
<term>Reaction Time</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Association Learning</term>
<term>Maze Learning</term>
<term>Reaction Time</term>
<term>Retention (Psychology)</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Learning Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Deep Brain Stimulation</term>
<term>Disability Evaluation</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Photic Stimulation</term>
<term>Time Factors</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evidence has been provided in Parkinson's disease patients of cognitive impairments including visual memory and learning which can be partially compensated by dopamine medication or subthalamic nucleus stimulation. The effects of these two therapies can differ according to the learning processes involving the dorsal vs ventral part of the striatum. Here we aimed to investigate and compare the outcomes of dopamine vs stimulation treatment in Parkinson patient's ability to acquire and maintain over successive days their performance in visual working memory. Parkinson patients performed conditional associative learning embedded in visual (spatial and non spatial) working memory tasks over two consecutive days either ON or OFF dopaminergic drugs or STN stimulation depending on the group of patients studied. While Parkinson patients were more accurate and faster in memory tasks ON vs OFF stimulation independent of the day of testing, performance in medicated patients differed depending on the medication status during the initial task acquisition. Patients who learnt the task ON medication the first day were able to maintain or even improve their memory performance both OFF and ON medication on the second day after consolidation. These effects were observed only in patients with dopamine replacement with or without motor fluctuations. This enhancement in memory performance after having learnt under dopamine medication and not under STN stimulation was mostly significant in visuo-spatial working memory tasks suggesting that dopamine replacement in the depleted dorsal striatum is essential for retention and consolidation of learnt skill.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001920 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001920 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:26778783 |texte= Distinct effects of dopamine vs STN stimulation therapies in associative learning and retention in Parkinson disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:26778783" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
This area was generated with Dilib version V0.6.29. |