Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures.
Identifieur interne : 000162 ( PubMed/Checkpoint ); précédent : 000161; suivant : 000163Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures.
Auteurs : Yehezkel Ben-Ari [France] ; Philippe Damier [France] ; Eric Lemonnier [France]Source :
- Frontiers in cellular neuroscience ; 2016.
Abstract
The diuretic bumetanide failed to treat acute seizures due to hypoxic ischemic encephalopathy (HIE) in newborn babies and was associated with hearing loss (NEMO trial, Pressler et al., 2015). On the other hand, clinical and experimental observations suggest that the diuretic might provide novel therapy for many brain disorders including Autism Spectrum Disorders (ASD), schizophrenia, Rett syndrome, and Parkinson disease. Here, we discuss the differences between the pathophysiology of severe recurrent seizures in the neonates and neurological and psychiatric disorders stressing the uniqueness of severe seizures in newborn in comparison to other disorders.
DOI: 10.3389/fncel.2016.00090
PubMed: 27147965
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On the other hand, clinical and experimental observations suggest that the diuretic might provide novel therapy for many brain disorders including Autism Spectrum Disorders (ASD), schizophrenia, Rett syndrome, and Parkinson disease. Here, we discuss the differences between the pathophysiology of severe recurrent seizures in the neonates and neurological and psychiatric disorders stressing the uniqueness of severe seizures in newborn in comparison to other disorders.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">27147965</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>05</Day></DateCreated><DateCompleted><Year>2016</Year><Month>05</Month><Day>05</Day></DateCompleted><DateRevised><Year>2016</Year><Month>05</Month><Day>07</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><JournalIssue CitedMedium="Print"><Volume>10</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Frontiers in cellular neuroscience</Title><ISOAbbreviation>Front Cell Neurosci</ISOAbbreviation></Journal><ArticleTitle>Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures.</ArticleTitle><Pagination><MedlinePgn>90</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fncel.2016.00090</ELocationID><Abstract><AbstractText>The diuretic bumetanide failed to treat acute seizures due to hypoxic ischemic encephalopathy (HIE) in newborn babies and was associated with hearing loss (NEMO trial, Pressler et al., 2015). On the other hand, clinical and experimental observations suggest that the diuretic might provide novel therapy for many brain disorders including Autism Spectrum Disorders (ASD), schizophrenia, Rett syndrome, and Parkinson disease. Here, we discuss the differences between the pathophysiology of severe recurrent seizures in the neonates and neurological and psychiatric disorders stressing the uniqueness of severe seizures in newborn in comparison to other disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ben-Ari</LastName><ForeName>Yehezkel</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>INMED - Institut National de la Santé et de la Recherche Médicale U901, Aix-Marseille University Marseilles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Damier</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale, Centre d'Investigation Clinique 0004 Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lemonnier</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Hôpital Le Cluzeau, CHU Limoges Limoges, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Cell Neurosci</MedlineTA><NlmUniqueID>101477935</NlmUniqueID><ISSNLinking>1662-5102</ISSNLinking></MedlineJournalInfo><OtherID Source="NLM">PMC4830840</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">GABA</Keyword><Keyword MajorTopicYN="N">autism</Keyword><Keyword MajorTopicYN="N">bumetanide</Keyword><Keyword MajorTopicYN="N">clinical trials</Keyword><Keyword MajorTopicYN="N">epilepsy</Keyword><Keyword MajorTopicYN="N">parkinson disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>5</Month><Day>6</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27147965</ArticleId><ArticleId IdType="doi">10.3389/fncel.2016.00090</ArticleId><ArticleId IdType="pmc">PMC4830840</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Ben Ari, Yehezkel" sort="Ben Ari, Yehezkel" uniqKey="Ben Ari Y" first="Yehezkel" last="Ben-Ari">Yehezkel Ben-Ari</name></noRegion><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name><name sortKey="Lemonnier, Eric" sort="Lemonnier, Eric" uniqKey="Lemonnier E" first="Eric" last="Lemonnier">Eric Lemonnier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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