Omics analysis of mouse brain models of human diseases.
Identifieur interne : 001B63 ( Ncbi/Checkpoint ); précédent : 001B62; suivant : 001B64Omics analysis of mouse brain models of human diseases.
Auteurs : Véronique Paban [France] ; Béatrice Loriod [France] ; Claude Villard [France] ; Luc Buee [France] ; David Blum [France] ; Susanna Pietropaolo [France] ; Yoon H. Cho [France] ; Sylvie Gory-Faure [France] ; Elodie Mansour [France] ; Ali Gharbi [France] ; Béatrice Alescio-Lautier [France]Source :
- Gene [ 1879-0038 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Behavior, Animal, Brain Diseases (genetics), Brain Diseases (metabolism), Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Genomics (methods), Humans, Male, Mental Disorders (genetics), Mental Disorders (metabolism), Metabolic Networks and Pathways, Mice, Mice, Knockout, Mice, Transgenic, Neurodegenerative Diseases (genetics), Neurodegenerative Diseases (metabolism), Proteomics (methods).
- MESH :
- genetics : Brain Diseases, Mental Disorders, Neurodegenerative Diseases.
- metabolism : Brain Diseases, Mental Disorders, Neurodegenerative Diseases.
- methods : Genomics, Proteomics.
- Animals, Behavior, Animal, Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Humans, Male, Metabolic Networks and Pathways, Mice, Mice, Knockout, Mice, Transgenic.
Abstract
The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.
DOI: 10.1016/j.gene.2016.11.022
PubMed: 27871923
Affiliations:
- France
- Aquitaine, Auvergne-Rhône-Alpes, Hauts-de-France, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Provence-Alpes-Côte d'Azur, Rhône-Alpes
- Bordeaux, Grenoble, Lille, Marseille
- Université de Bordeaux
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pubmed:27871923Le document en format XML
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<author><name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name>
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<author><name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name>
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<author><name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Behavior, Animal</term>
<term>Brain Diseases (genetics)</term>
<term>Brain Diseases (metabolism)</term>
<term>Disease Models, Animal</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Genomics (methods)</term>
<term>Humans</term>
<term>Male</term>
<term>Mental Disorders (genetics)</term>
<term>Mental Disorders (metabolism)</term>
<term>Metabolic Networks and Pathways</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Mice, Transgenic</term>
<term>Neurodegenerative Diseases (genetics)</term>
<term>Neurodegenerative Diseases (metabolism)</term>
<term>Proteomics (methods)</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brain Diseases</term>
<term>Mental Disorders</term>
<term>Neurodegenerative Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Diseases</term>
<term>Mental Disorders</term>
<term>Neurodegenerative Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genomics</term>
<term>Proteomics</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Behavior, Animal</term>
<term>Disease Models, Animal</term>
<term>Gene Expression Profiling</term>
<term>Gene Regulatory Networks</term>
<term>Humans</term>
<term>Male</term>
<term>Metabolic Networks and Pathways</term>
<term>Mice</term>
<term>Mice, Knockout</term>
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<front><div type="abstract" xml:lang="en">The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.</div>
</front>
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<li>Auvergne-Rhône-Alpes</li>
<li>Hauts-de-France</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Aquitaine</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhône-Alpes</li>
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<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Paban, Veronique" sort="Paban, Veronique" uniqKey="Paban V" first="Véronique" last="Paban">Véronique Paban</name>
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<name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name>
<name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name>
<name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name>
<name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name>
<name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name>
<name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Faure">Sylvie Gory-Faure</name>
<name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name>
<name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name>
<name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name>
<name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name>
</country>
</tree>
</affiliations>
</record>
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