A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients.
Identifieur interne : 001970 ( Ncbi/Checkpoint ); précédent : 001969; suivant : 001971A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients.
Auteurs : N. Simon [France] ; F. Viallet [France] ; A. Boulamery [France] ; A. Eusebio [France] ; D. Gayraud [France] ; J-P Azulay [France]Source :
- European journal of clinical pharmacology [ 1432-1041 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Aged, Female, Humans, Male, Middle Aged, Models, Biological, Prospective Studies.
Abstract
Levodopa is the reference treatment for Parkinson's disease. However, after several years of treatment, dyskinesia may occur and strategies to overcome this side effect still need to be explored. We identified a unique population pharmacokinetic/pharmacodynamic model in Parkinson's disease to investigate the relationship and dissociability of motor response and dyskinesia.
DOI: 10.1007/s00228-016-2034-0
PubMed: 26936272
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000164
- to stream PubMed, to step Curation: 000164
- to stream PubMed, to step Checkpoint: 000164
- to stream Ncbi, to step Merge: 001970
- to stream Ncbi, to step Curation: 001970
Links to Exploration step
pubmed:26936272Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients.</title>
<author><name sortKey="Simon, N" sort="Simon, N" uniqKey="Simon N" first="N" last="Simon">N. Simon</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille, France. nicolas.Simon@ap-hm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F" last="Viallet">F. Viallet</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boulamery, A" sort="Boulamery, A" uniqKey="Boulamery A" first="A" last="Boulamery">A. Boulamery</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, CHU Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gayraud, D" sort="Gayraud, D" uniqKey="Gayraud D" first="D" last="Gayraud">D. Gayraud</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J-P" last="Azulay">J-P Azulay</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, CHU Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26936272</idno>
<idno type="pmid">26936272</idno>
<idno type="doi">10.1007/s00228-016-2034-0</idno>
<idno type="wicri:Area/PubMed/Corpus">000164</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000164</idno>
<idno type="wicri:Area/PubMed/Curation">000164</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000164</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000164</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000164</idno>
<idno type="wicri:Area/Ncbi/Merge">001970</idno>
<idno type="wicri:Area/Ncbi/Curation">001970</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001970</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients.</title>
<author><name sortKey="Simon, N" sort="Simon, N" uniqKey="Simon N" first="N" last="Simon">N. Simon</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille, France. nicolas.Simon@ap-hm.fr.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F" last="Viallet">F. Viallet</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boulamery, A" sort="Boulamery, A" uniqKey="Boulamery A" first="A" last="Boulamery">A. Boulamery</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Pharmacologie Clinique, AP-HM, Hôpital Sainte Marguerite, CAP-TV, 13274, Marseille</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, CHU Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gayraud, D" sort="Gayraud, D" uniqKey="Gayraud D" first="D" last="Gayraud">D. Gayraud</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de neurologie, Centre Hospitalier Intercommunal Aix Pertuis, 13613, Aix-en-Provence</wicri:regionArea>
<placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Aix-en-Provence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J-P" last="Azulay">J-P Azulay</name>
<affiliation wicri:level="3"><nlm:affiliation>Service de Neurologie, CHU Timone, Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU Timone, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">European journal of clinical pharmacology</title>
<idno type="eISSN">1432-1041</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Biological</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Prospective Studies</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Biological</term>
<term>Prospective Studies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Levodopa is the reference treatment for Parkinson's disease. However, after several years of treatment, dyskinesia may occur and strategies to overcome this side effect still need to be explored. We identified a unique population pharmacokinetic/pharmacodynamic model in Parkinson's disease to investigate the relationship and dissociability of motor response and dyskinesia.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Aix-en-Provence</li>
<li>Marseille</li>
</settlement>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Simon, N" sort="Simon, N" uniqKey="Simon N" first="N" last="Simon">N. Simon</name>
</region>
<name sortKey="Azulay, J P" sort="Azulay, J P" uniqKey="Azulay J" first="J-P" last="Azulay">J-P Azulay</name>
<name sortKey="Boulamery, A" sort="Boulamery, A" uniqKey="Boulamery A" first="A" last="Boulamery">A. Boulamery</name>
<name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name>
<name sortKey="Gayraud, D" sort="Gayraud, D" uniqKey="Gayraud D" first="D" last="Gayraud">D. Gayraud</name>
<name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F" last="Viallet">F. Viallet</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001970 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001970 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:26936272 |texte= A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:26936272" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
This area was generated with Dilib version V0.6.29. |