A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients.
Identifieur interne : 001970 ( Ncbi/Curation ); précédent : 001969; suivant : 001971A combined pharmacokinetic/pharmacodynamic model of levodopa motor response and dyskinesia in Parkinson's disease patients.
Auteurs : N. Simon [France] ; F. Viallet [France] ; A. Boulamery [France] ; A. Eusebio [France] ; D. Gayraud [France] ; J-P Azulay [France]Source :
- European journal of clinical pharmacology [ 1432-1041 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Aged, Female, Humans, Male, Middle Aged, Models, Biological, Prospective Studies.
Abstract
Levodopa is the reference treatment for Parkinson's disease. However, after several years of treatment, dyskinesia may occur and strategies to overcome this side effect still need to be explored. We identified a unique population pharmacokinetic/pharmacodynamic model in Parkinson's disease to investigate the relationship and dissociability of motor response and dyskinesia.
DOI: 10.1007/s00228-016-2034-0
PubMed: 26936272
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pubmed:26936272Le document en format XML
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<front><div type="abstract" xml:lang="en">Levodopa is the reference treatment for Parkinson's disease. However, after several years of treatment, dyskinesia may occur and strategies to overcome this side effect still need to be explored. We identified a unique population pharmacokinetic/pharmacodynamic model in Parkinson's disease to investigate the relationship and dissociability of motor response and dyskinesia.</div>
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