Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients
Identifieur interne : 000A18 ( Ncbi/Checkpoint ); précédent : 000A17; suivant : 000A19Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients
Auteurs : Cyrille Vernet [France] ; Isabelle Arnulf [France]Source :
- Sleep [ 0161-8105 ] ; 2009.
Abstract
To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.
University Hospital
Controlled, prospective cohort
75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.
Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h
Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m2; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.
Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.
Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients.
Url:
PubMed: 19544751
PubMed Central: 2690562
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000357
- to stream Pmc, to step Curation: 000354
- to stream Pmc, to step Checkpoint: 000815
- to stream Ncbi, to step Merge: 000A18
- to stream Ncbi, to step Curation: 000A18
Links to Exploration step
PMC:2690562Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients</title>
<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence national narcolepsie et hypersomnie</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence national narcolepsie et hypersomnie</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19544751</idno>
<idno type="pmc">2690562</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690562</idno>
<idno type="RBID">PMC:2690562</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000357</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000357</idno>
<idno type="wicri:Area/Pmc/Curation">000354</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000354</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000815</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000815</idno>
<idno type="wicri:Area/Ncbi/Merge">000A18</idno>
<idno type="wicri:Area/Ncbi/Curation">000A18</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A18</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients</title>
<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence national narcolepsie et hypersomnie</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence national narcolepsie et hypersomnie</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
<idno type="eISSN">1550-9109</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.</p>
</sec>
<sec><title>Setting:</title>
<p>University Hospital</p>
</sec>
<sec><title>Design:</title>
<p>Controlled, prospective cohort</p>
</sec>
<sec><title>Participants:</title>
<p>75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.</p>
</sec>
<sec><title>Intervention:</title>
<p>Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h <italic>ad libitum</italic>
sleep monitoring.</p>
</sec>
<sec><title>Results:</title>
<p>Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m<sup>2</sup>
; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.</p>
</sec>
<sec><title>Citation:</title>
<p>Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. <italic>SLEEP</italic>
2009;32(6):753-759.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
</region>
<name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A18 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000A18 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:2690562 |texte= Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:19544751" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |