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Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Identifieur interne : 000A18 ( Ncbi/Checkpoint ); précédent : 000A17; suivant : 000A19

Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Auteurs : Cyrille Vernet [France] ; Isabelle Arnulf [France]

Source :

Sleep [ 0161-8105 ] ; 2009.

RBID : PMC:2690562

Abstract

Objective:

To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.

Setting:

University Hospital

Design:

Controlled, prospective cohort

Participants:

75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.

Intervention:

Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h ad libitum sleep monitoring.

Results:

Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m²; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.

Conclusions:

Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.

Citation:

Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. SLEEP 2009;32(6):753-759.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690562

PubMed: 19544751
PubMed Central: 2690562

Affiliations:

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PMC:2690562

Le document en format XML

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<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.</p>
</sec>
<sec><title>Setting:</title>
<p>University Hospital</p>
</sec>
<sec><title>Design:</title>
<p>Controlled, prospective cohort</p>
</sec>
<sec><title>Participants:</title>
<p>75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.</p>
</sec>
<sec><title>Intervention:</title>
<p>Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h <italic>ad libitum</italic>
 sleep monitoring.</p>
</sec>
<sec><title>Results:</title>
<p>Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m<sup>2</sup>
; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.</p>
</sec>
<sec><title>Citation:</title>
<p>Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. <italic>SLEEP</italic>
 2009;32(6):753-759.</p>
</sec>
</div>
</front>
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<name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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<name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
</country>
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</affiliations>
</record>

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Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki