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Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Identifieur interne : 000357 ( Pmc/Corpus ); précédent : 000356; suivant : 000358

Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Auteurs : Cyrille Vernet ; Isabelle Arnulf

Source :

Sleep [ 0161-8105 ] ; 2009.

RBID : PMC:2690562

Abstract

Objective:

To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.

Setting:

University Hospital

Design:

Controlled, prospective cohort

Participants:

75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.

Intervention:

Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h ad libitum sleep monitoring.

Results:

Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m²; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.

Conclusions:

Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.

Citation:

Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. SLEEP 2009;32(6):753-759.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690562

PubMed: 19544751
PubMed Central: 2690562

Links to Exploration step

PMC:2690562

Le document en format XML

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<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<affiliation><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients</title>
<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<affiliation><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
<idno type="eISSN">1550-9109</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.</p>
</sec>
<sec><title>Setting:</title>
<p>University Hospital</p>
</sec>
<sec><title>Design:</title>
<p>Controlled, prospective cohort</p>
</sec>
<sec><title>Participants:</title>
<p>75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.</p>
</sec>
<sec><title>Intervention:</title>
<p>Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h <italic>ad libitum</italic>
 sleep monitoring.</p>
</sec>
<sec><title>Results:</title>
<p>Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m<sup>2</sup>
; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.</p>
</sec>
<sec><title>Citation:</title>
<p>Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. <italic>SLEEP</italic>
 2009;32(6):753-759.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id>
<journal-id journal-id-type="publisher-id">Sleep</journal-id>
<journal-title>Sleep</journal-title>
<issn pub-type="ppub">0161-8105</issn>
<issn pub-type="epub">1550-9109</issn>
<publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19544751</article-id>
<article-id pub-id-type="pmc">2690562</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Idiopathic Hypersomnolence And Sleep Duration</subject>
</subj-group>
</article-categories>
<title-group><article-title>Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Vernet</surname>
<given-names>Cyrille</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arnulf</surname>
<given-names>Isabelle</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</aff>
<aff id="aff2"><label>2</label>
Paris 6 University, Paris, France</aff>
<aff id="aff3"><label>3</label>
Centre de référence national narcolepsie et hypersomnie, France</aff>
<author-notes><corresp id="cor1">Address correspondence to: Isabelle Arnulf, MD, PhD, 
<addr-line>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France</addr-line>
<phone>+33 1 42 16 77 02</phone>
<fax>+33 1 42 16 77 00</fax>
<email>isabelle.arnulf@psl.aphp.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>6</month>
<year>2009</year>
</pub-date>
<volume>32</volume>
<issue>6</issue>
<fpage>753</fpage>
<lpage>759</lpage>
<history><date date-type="received"><month>10</month>
<year>2008</year>
</date>
<date date-type="rev-recd"><month>2</month>
<year>2009</year>
</date>
<date date-type="accepted"><month>2</month>
<year>2009</year>
</date>
</history>
<copyright-statement>© 2009 Associated Professional Sleep Societies, LLC.</copyright-statement>
<copyright-year>2009</copyright-year>
<abstract><sec><title>Objective:</title>
<p>To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.</p>
</sec>
<sec><title>Setting:</title>
<p>University Hospital</p>
</sec>
<sec><title>Design:</title>
<p>Controlled, prospective cohort</p>
</sec>
<sec><title>Participants:</title>
<p>75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.</p>
</sec>
<sec><title>Intervention:</title>
<p>Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h <italic>ad libitum</italic>
 sleep monitoring.</p>
</sec>
<sec><title>Results:</title>
<p>Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m<sup>2</sup>
; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.</p>
</sec>
<sec><title>Citation:</title>
<p>Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. <italic>SLEEP</italic>
 2009;32(6):753-759.</p>
</sec>
</abstract>
<kwd-group><kwd>Hypersomnia</kwd>
<kwd>long sleep time</kwd>
<kwd>MSLT</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki