Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients
Identifieur interne : 000354 ( Pmc/Curation ); précédent : 000353; suivant : 000355Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients
Auteurs : Cyrille Vernet [France] ; Isabelle Arnulf [France]Source :
- Sleep [ 0161-8105 ] ; 2009.
Abstract
To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.
University Hospital
Controlled, prospective cohort
75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.
Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h
Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m2; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.
Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.
Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients.
Url:
PubMed: 19544751
PubMed Central: 2690562
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<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients</title>
<author><name sortKey="Vernet, Cyrille" sort="Vernet, Cyrille" uniqKey="Vernet C" first="Cyrille" last="Vernet">Cyrille Vernet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="1"><nlm:aff id="aff2">Paris 6 University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3">Centre de référence national narcolepsie et hypersomnie, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence national narcolepsie et hypersomnie</wicri:regionArea>
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<author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Paris 6 University, Paris</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence national narcolepsie et hypersomnie</wicri:regionArea>
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<series><title level="j">Sleep</title>
<idno type="ISSN">0161-8105</idno>
<idno type="eISSN">1550-9109</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.</p>
</sec>
<sec><title>Setting:</title>
<p>University Hospital</p>
</sec>
<sec><title>Design:</title>
<p>Controlled, prospective cohort</p>
</sec>
<sec><title>Participants:</title>
<p>75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.</p>
</sec>
<sec><title>Intervention:</title>
<p>Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h <italic>ad libitum</italic>
sleep monitoring.</p>
</sec>
<sec><title>Results:</title>
<p>Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m<sup>2</sup>
; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.</p>
</sec>
<sec><title>Citation:</title>
<p>Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. <italic>SLEEP</italic>
2009;32(6):753-759.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id>
<journal-id journal-id-type="publisher-id">Sleep</journal-id>
<journal-title>Sleep</journal-title>
<issn pub-type="ppub">0161-8105</issn>
<issn pub-type="epub">1550-9109</issn>
<publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19544751</article-id>
<article-id pub-id-type="pmc">2690562</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Idiopathic Hypersomnolence And Sleep Duration</subject>
</subj-group>
</article-categories>
<title-group><article-title>Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Vernet</surname>
<given-names>Cyrille</given-names>
</name>
<degrees>MSc</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arnulf</surname>
<given-names>Isabelle</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, Paris, France</aff>
<aff id="aff2"><label>2</label>
Paris 6 University, Paris, France</aff>
<aff id="aff3"><label>3</label>
Centre de référence national narcolepsie et hypersomnie, France</aff>
<author-notes><corresp id="cor1">Address correspondence to: Isabelle Arnulf, MD, PhD,
<addr-line>Unité des Pathologies du Sommeil, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France</addr-line>
<phone>+33 1 42 16 77 02</phone>
<fax>+33 1 42 16 77 00</fax>
<email>isabelle.arnulf@psl.aphp.fr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>6</month>
<year>2009</year>
</pub-date>
<volume>32</volume>
<issue>6</issue>
<fpage>753</fpage>
<lpage>759</lpage>
<history><date date-type="received"><month>10</month>
<year>2008</year>
</date>
<date date-type="rev-recd"><month>2</month>
<year>2009</year>
</date>
<date date-type="accepted"><month>2</month>
<year>2009</year>
</date>
</history>
<copyright-statement>© 2009 Associated Professional Sleep Societies, LLC.</copyright-statement>
<copyright-year>2009</copyright-year>
<abstract><sec><title>Objective:</title>
<p>To characterize the clinical, psychological, and sleep pattern of idiopathic hypersomnia with and without long sleep time, and provide normative values for 24-hour polysomnography.</p>
</sec>
<sec><title>Setting:</title>
<p>University Hospital</p>
</sec>
<sec><title>Design:</title>
<p>Controlled, prospective cohort</p>
</sec>
<sec><title>Participants:</title>
<p>75 consecutive patients (aged 34 ± 12 y) with idiopathic hypersomnia and 30 healthy matched controls.</p>
</sec>
<sec><title>Intervention:</title>
<p>Patients and controls underwent during 48 hours a face-to face interview, questionnaires, human leukocyte antigen genotype, a night polysomnography and multiple sleep latency test (MSLT), followed by 24-h <italic>ad libitum</italic>
sleep monitoring.</p>
</sec>
<sec><title>Results:</title>
<p>Hypersomniacs had more fatigue, higher anxiety and depression scores, and more frequent hypnagogic hallucinations (24%), sleep paralysis (28%), sleep drunkenness (36%), and unrefreshing naps (46%) than controls. They were more frequently evening types. DQB1*0602 genotype was similarly found in hypersomniacs (24.2%) and controls (19.2%). Hypersomniacs had more frequent slow wave sleep after 06:00 than controls. During 24-h polysomnography, the 95% confidence interval for total sleep time was 493–558 min in controls, versus 672–718 min in hypersomniacs. There were 40 hypersomniacs with and 35 hypersomniacs without long ( > 600 min) sleep time. The hypersomniacs with long sleep time were younger (29 ± 10 vs 40 ± 13 y, P = 0.0002), slimmer (body mass index: 26 ± 5 vs 23 ± 4 kg/m<sup>2</sup>
; P = 0.005), and had lower Horne-Ostberg scores and higher sleep efficiencies than those without long sleep time. MSLT latencies were normal ( > 8 min) in 71% hypersomniacs with long sleep time.</p>
</sec>
<sec><title>Conclusions:</title>
<p>Hypersomnia, especially with long sleep time, is frequently associated with evening chronotype and young age. It is inadequately diagnosed using MSLT.</p>
</sec>
<sec><title>Citation:</title>
<p>Vernet C; Arnulf I. Idiopathic Hypersomnia with and without Long Sleep Time: A Controlled Series of 75 Patients. <italic>SLEEP</italic>
2009;32(6):753-759.</p>
</sec>
</abstract>
<kwd-group><kwd>Hypersomnia</kwd>
<kwd>long sleep time</kwd>
<kwd>MSLT</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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