ParkinsonFranceV1, Main, Merge, bibRecord, 004C83

Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice

Identifieur interne : 004C83 ( Main/Merge ); précédent : 004C82; suivant : 004C84

Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice

Auteurs : E. Bezard [France] ; S. Dovero [France] ; B. Bioulac [France] ; C. Gross [France]

Source :

Experimental neurology [ 0014-4886 ] ; 1997.

RBID : Pascal:98-0055833

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Pyridine(1-méthyl-4-phényl-1,2,3,6-tétrahydro), Dégénérescence, Neurone dopaminergique, Rythme administration, Pathogénie, Animal, Souris, Etude comparative.

English descriptors

KwdEn :
- Administration schedule, Animal, Comparative study, Degeneration, Dopaminergic neuron, Mouse, Parkinson disease, Pathogenesis.

Abstract

Although a valuable 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) animal model of human Parkinson's disease has been developed, our knowledge of the course of nigral degeneration remains fragmentary. Experimental factors which could possibly influence the destructive process must be taken into account. To evaluate the impact of experimental design, we compared the effects of different schedules of injection of the same cumulative dose of MPTP, in mice, by measuring tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta. Massive injection of the total dose over 1 day (4 injections of 20 mg/kg) destroyed more dopaminergic neurons than did the long-term daily injections of a lower dose of MPTP (20 injections of 4 mg/kg). This suggests that different schedules of administration of MPTP might induce different mechanisms of neuronal death. These mechanisms need to be better understood if chronic models of intoxication that replicate the evolution of human Parkinson's disease more precisely are to be developed.

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Pascal:98-0055833

Le document en format XML

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<front><div type="abstract" xml:lang="en">Although a valuable 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) animal model of human Parkinson's disease has been developed, our knowledge of the course of nigral degeneration remains fragmentary. Experimental factors which could possibly influence the destructive process must be taken into account. To evaluate the impact of experimental design, we compared the effects of different schedules of injection of the same cumulative dose of MPTP, in mice, by measuring tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta. Massive injection of the total dose over 1 day (4 injections of 20 mg/kg) destroyed more dopaminergic neurons than did the long-term daily injections of a lower dose of MPTP (20 injections of 4 mg/kg). This suggests that different schedules of administration of MPTP might induce different mechanisms of neuronal death. These mechanisms need to be better understood if chronic models of intoxication that replicate the evolution of human Parkinson's disease more precisely are to be developed.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice

Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri