ParkinsonFranceV1, Main, Merge, bibRecord, 004C82

Effects of iron complexes on brain calcium homeostasis

Identifieur interne : 004C82 ( Main/Merge ); précédent : 004C81; suivant : 004C83

Effects of iron complexes on brain calcium homeostasis

Auteurs : L. J. Anghileri [France] ; P. Thouvenot [France] ; A. Bertrand [France]

Source :

Annals of clinical and laboratory science [ 0091-7370 ] ; 1997.

RBID : Pascal:97-0299238

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Homéostasie phosphocalcique, Calcium, Fer complexe, In vivo, Pathogénie, Animal, Souris, Rat, In vitro, Culture cellulaire.
Wicri :
- topic : Calcium.

English descriptors

KwdEn :
- Animal, Calcium, Cell culture, In vitro, In vivo, Iron complex, Mouse, Parkinson disease, Pathogenesis, Phosphocalcic homeostasis, Rat.

Abstract

The effects of two physiological low molecular weight iron complexes, ferric lactate and ferric adenosine triphosphate (ATP) on brain Ca²⁺ homeostasis modification, have been studied in vitro and in vivo. In vitro ferric ATP complex shows a higher efficiency as modifier of Ca²⁺ homeostasis. This higher reactivity and the in vivo observed effect of increased brain uptake of iron from ferric lactate provoked by the presence of ATP, corroborate in vitro results showing an iron transfer from ferric lactate to ATP, as well as the mediator role of ATP in the iron-induced cellular Ca²⁺ homeostasis modification process. The possible role of this process in Parkinson's disease is discussed.

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Pascal:97-0299238

Le document en format XML

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<front><div type="abstract" xml:lang="en">The effects of two physiological low molecular weight iron complexes, ferric lactate and ferric adenosine triphosphate (ATP) on brain Ca<sup>2+</sup>
 homeostasis modification, have been studied in vitro and in vivo. In vitro ferric ATP complex shows a higher efficiency as modifier of Ca<sup>2+</sup>
 homeostasis. This higher reactivity and the in vivo observed effect of increased brain uptake of iron from ferric lactate provoked by the presence of ATP, corroborate in vitro results showing an iron transfer from ferric lactate to ATP, as well as the mediator role of ATP in the iron-induced cellular Ca<sup>2+</sup>
 homeostasis modification process. The possible role of this process in Parkinson's disease is discussed.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Effects of iron complexes on brain calcium homeostasis

Effects of iron complexes on brain calcium homeostasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri