ParkinsonFranceV1, Main, Merge, bibRecord, 004C84

Effect of tolcapone on plasma and striatal apomorphine disposition in rats

Identifieur interne : 004C84 ( Main/Merge ); précédent : 004C83; suivant : 004C85

Effect of tolcapone on plasma and striatal apomorphine disposition in rats

Auteurs : F. Coudore [France] ; F. Durif [France] ; E. Duroux [France] ; A. Eschalier [France] ; J. Fialip [France]

Source :

Neuroreport : (Oxford) [ 0959-4965 ] ; 1997.

RBID : Pascal:97-0283334

Descripteurs français

Pascal (Inist)
- Corps strié, Apomorphine, Tolcapone, Inhibiteur enzyme, Catechol O-methyltransferase, Plasma sanguin, Antiparkinsonien, Agoniste, Récepteur dopaminergique, Biodisponibilité, Animal, Rat.

English descriptors

KwdEn :
- Agonist, Animal, Antiparkinson agent, Bioavailability, Blood plasma, Catechol O-methyltransferase, Corpus striatum, Dopamine receptor, Enzyme inhibitor, Rat, Tolcapone.

Abstract

THE influence of tolcapone, an inhibitor of catechol-O-methyl transferase, was evaluated on the disposition of apomorphine, a dopamine agonist used to treat Parkinson's disease, to explain a previously observed increase of duration of the effect of apomorphine associated with tolcapone. Sampling was performed in rats before and at different times after administration of apomorphine and following that of tolcapone or saline. Both in plasma and striatum, times to reach maximal concentration and maximal concentrations did not significantly differ between the two groups but the elimination half-life times and areas under the curve were significantly greater following tolcapone treatment than in the saline group. These results show that tolcapone can increase plasma apomorphine bioavailability by modifying its liver catabolism.

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Pascal:97-0283334

Le document en format XML

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<term>Blood plasma</term>
<term>Catechol O-methyltransferase</term>
<term>Corpus striatum</term>
<term>Dopamine receptor</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Corps strié</term>
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<term>Antiparkinsonien</term>
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<front><div type="abstract" xml:lang="en">THE influence of tolcapone, an inhibitor of catechol-O-methyl transferase, was evaluated on the disposition of apomorphine, a dopamine agonist used to treat Parkinson's disease, to explain a previously observed increase of duration of the effect of apomorphine associated with tolcapone. Sampling was performed in rats before and at different times after administration of apomorphine and following that of tolcapone or saline. Both in plasma and striatum, times to reach maximal concentration and maximal concentrations did not significantly differ between the two groups but the elimination half-life times and areas under the curve were significantly greater following tolcapone treatment than in the saline group. These results show that tolcapone can increase plasma apomorphine bioavailability by modifying its liver catabolism.</div>
</front>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Effect of tolcapone on plasma and striatal apomorphine disposition in rats

Effect of tolcapone on plasma and striatal apomorphine disposition in rats

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri