Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
Identifieur interne : 001C20 ( Main/Merge ); précédent : 001C19; suivant : 001C21Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
Auteurs : A. Eusebio [Royaume-Uni, France] ; W. Thevathasan [Royaume-Uni] ; L. Doyle Gaynor [Royaume-Uni] ; A. Pogosyan [Royaume-Uni] ; E. Bye [Royaume-Uni] ; T. Foltynie [Royaume-Uni] ; L. Zrinzo [Royaume-Uni] ; K. Ashkan [Royaume-Uni] ; T. Aziz [Royaume-Uni] ; P. Brown [Royaume-Uni]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2011-05.
English descriptors
- mix :
Abstract
Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.
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- https://api.istex.fr/document/293DA10CF672BED0E6B8B1BEFB56FB3229B2D373/fulltext/pdf
- https://hal.archives-ouvertes.fr/hal-00585779
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072048
DOI: 10.1136/jnnp.2010.217489
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ISTEX:293DA10CF672BED0E6B8B1BEFB56FB3229B2D373Le document en format XML
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Foltynie</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="569">569</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">293DA10CF672BED0E6B8B1BEFB56FB3229B2D373</idno><idno type="DOI">10.1136/jnnp.2010.217489</idno><idno type="href">jnnp-82-569.pdf</idno><idno type="ArticleID">jnnp217489</idno><idno type="PMID">20935326</idno><idno type="local">jnnp;82/5/569</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>ELECTRICAL STIMULATION</term><term>MOTOR</term><term>MOTOR PHYSIOLOGY</term><term>MOVEMENT DISORDERS</term><term>NEUROPHYSIOLOGY</term><term>PARKINSON'S DISEASE</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div></front></TEI><double doi="10.1136/jnnp.2010.217489"><HAL><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep Brain Stimulation can suppress pathological synchronization in parkinsonian patients</title><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300093" status="VALID"> <idno type="ISNI">0000 0001 0404 1115 </idno> <orgName> Hôpital de la Timone [CHU - APHM]</orgName> <orgName type="acronym">TIMONE</orgName> <date type="start">1974</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref> </desc></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Thevathasan, Wesley" sort="Thevathasan, Wesley" uniqKey="Thevathasan W" first="Wesley" last="Thevathasan">Wesley Thevathasan</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218831" status="VALID"> <orgName>University of Oxford (UK)</orgName> <desc> <address> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Doyle Gaynor, Louise" sort="Doyle Gaynor, Louise" uniqKey="Doyle Gaynor L" first="Louise" last="Doyle Gaynor">Louise Doyle Gaynor</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Pogosyan, Alek" sort="Pogosyan, Alek" uniqKey="Pogosyan A" first="Alek" last="Pogosyan">Alek Pogosyan</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Bye, Ed" sort="Bye, Ed" uniqKey="Bye E" first="Ed" last="Bye">Ed Bye</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Foltynie, Tom" sort="Foltynie, Tom" uniqKey="Foltynie T" first="Tom" last="Foltynie">Tom Foltynie</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" 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Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300093" status="VALID"> <idno type="ISNI">0000 0001 0404 1115 </idno> <orgName> Hôpital de la Timone [CHU - APHM]</orgName> <orgName type="acronym">TIMONE</orgName> <date type="start">1974</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-de-la-timone</ref> </desc></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Thevathasan, Wesley" sort="Thevathasan, Wesley" uniqKey="Thevathasan W" first="Wesley" last="Thevathasan">Wesley Thevathasan</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218831" status="VALID"> <orgName>University of Oxford (UK)</orgName> <desc> <address> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Doyle Gaynor, Louise" sort="Doyle Gaynor, Louise" uniqKey="Doyle Gaynor L" first="Louise" last="Doyle Gaynor">Louise Doyle Gaynor</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Pogosyan, Alek" sort="Pogosyan, Alek" uniqKey="Pogosyan A" first="Alek" last="Pogosyan">Alek Pogosyan</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Bye, Ed" sort="Bye, Ed" uniqKey="Bye E" first="Ed" last="Bye">Ed Bye</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Foltynie, Tom" sort="Foltynie, Tom" uniqKey="Foltynie T" first="Tom" last="Foltynie">Tom Foltynie</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Zrinzo, Ludvic" sort="Zrinzo, Ludvic" uniqKey="Zrinzo L" first="Ludvic" last="Zrinzo">Ludvic Zrinzo</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300875" status="VALID"> <orgName>University College of London [London]</orgName> <desc> <address> <addrLine>Gower Street, London WC1E 6BT </addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ucl.ac.uk/</ref> </desc></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Ashkan, Keymour" sort="Ashkan, Keymour" uniqKey="Ashkan K" first="Keymour" last="Ashkan">Keymour Ashkan</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-152917" status="INCOMING"> <orgName>Kings College Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-327063" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-327063" type="direct"><org type="institution" xml:id="struct-327063" status="INCOMING"> <orgName>Kings College Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Aziz, Tipu" sort="Aziz, Tipu" uniqKey="Aziz T" first="Tipu" last="Aziz">Tipu Aziz</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-218831" status="VALID"> <orgName>University of Oxford (UK)</orgName> <desc> <address> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-16095" status="INCOMING"> <orgName>University of Oxford, Atmospheric, Oceanic and Planetary Physics</orgName> <desc> <address> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author></analytic><idno type="DOI">10.1136/jnnp.2010.217489</idno><series><title level="j">Journal of Neurology, Neurosurgery and Psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date type="datePub">2010-10-09</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>ELECTRICAL STIMULATION</term><term>MOTOR</term><term>MOTOR PHYSIOLOGY</term><term>MOVEMENT DISORDERS</term><term>NEUROPHYSIOLOGY</term><term>PARKINSON'S DISEASE</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronized oscillatory activity. To explore this we recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse-width 60µs; frequency 130 Hz) of the same target using a specially designed amplifier. We analyzed data from 25 sides and found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54 % of baseline values by a stimulation intensity of 3.0 V. The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div></front></TEI></HAL><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title><author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name></author><author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name></author><author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name></author><author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name></author><author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name></author><author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:293DA10CF672BED0E6B8B1BEFB56FB3229B2D373</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1136/jnnp.2010.217489</idno><idno type="url">https://api.istex.fr/document/293DA10CF672BED0E6B8B1BEFB56FB3229B2D373/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002241</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002241</idno><idno type="wicri:Area/Istex/Curation">002239</idno><idno type="wicri:Area/Istex/Checkpoint">000444</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000444</idno><idno type="wicri:doubleKey">0022-3050:2010:Eusebio A:deep:brain:stimulation</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title><author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2011-05">2011-05</date><biblScope unit="volume">82</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="569">569</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">293DA10CF672BED0E6B8B1BEFB56FB3229B2D373</idno><idno type="DOI">10.1136/jnnp.2010.217489</idno><idno type="href">jnnp-82-569.pdf</idno><idno type="ArticleID">jnnp217489</idno><idno type="PMID">20935326</idno><idno type="local">jnnp;82/5/569</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title><author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurology and Movement Disorders, Timone University Hospital, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><nlm:aff id="aff4">Neurosurgery, King's College Hospital, Denmark Hill, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20935326</idno><idno type="pmc">3072048</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072048</idno><idno type="RBID">PMC:3072048</idno><idno type="doi">10.1136/jnnp.2010.217489</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000775</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000775</idno><idno type="wicri:Area/Pmc/Curation">000772</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000772</idno><idno type="wicri:Area/Pmc/Checkpoint">000767</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000767</idno><idno type="wicri:Area/Ncbi/Merge">000C29</idno><idno type="wicri:Area/Ncbi/Curation">000C29</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C29</idno><idno type="wicri:doubleKey">0022-3050:2010:Eusebio A:deep:brain:stimulation</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title><author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurology and Movement Disorders, Timone University Hospital, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><nlm:aff id="aff4">Neurosurgery, King's College Hospital, Denmark Hill, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.</p></sec><sec><title>Methods</title><p>To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.</p></sec><sec><title>Results</title><p>The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.</p></sec><sec><title>Conclusion</title><p>The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. 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Moro</name></author><author><name sortKey="Esselink, Rj" uniqKey="Esselink R">RJ Esselink</name></author><author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, R" uniqKey="Levy R">R Levy</name></author><author><name sortKey="Ashby, P" uniqKey="Ashby P">P Ashby</name></author><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberger, M" uniqKey="Weinberger M">M Weinberger</name></author><author><name sortKey="Mahant, N" uniqKey="Mahant N">N Mahant</name></author><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanslaski, S" uniqKey="Stanslaski S">S Stanslaski</name></author><author><name sortKey="Cong, P" uniqKey="Cong P">P Cong</name></author><author><name sortKey="Carlson, D" uniqKey="Carlson D">D Carlson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Cc" uniqKey="Chen C">CC Chen</name></author><author><name sortKey="Hsu, Yt" uniqKey="Hsu Y">YT Hsu</name></author><author><name sortKey="Chan, Hl" uniqKey="Chan H">HL Chan</name></author></analytic></biblStruct></listBibl></div1></back></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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