Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
Identifieur interne : 001C20 ( Main/Merge ); précédent : 001C19; suivant : 001C21Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
Auteurs : A. Eusebio [Royaume-Uni, France] ; W. Thevathasan [Royaume-Uni] ; L. Doyle Gaynor [Royaume-Uni] ; A. Pogosyan [Royaume-Uni] ; E. Bye [Royaume-Uni] ; T. Foltynie [Royaume-Uni] ; L. Zrinzo [Royaume-Uni] ; K. Ashkan [Royaume-Uni] ; T. Aziz [Royaume-Uni] ; P. Brown [Royaume-Uni]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2011-05.
English descriptors
- mix :
Abstract
Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.
Url:
- https://api.istex.fr/document/293DA10CF672BED0E6B8B1BEFB56FB3229B2D373/fulltext/pdf
- https://hal.archives-ouvertes.fr/hal-00585779
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072048
DOI: 10.1136/jnnp.2010.217489
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<front><div type="abstract">Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div>
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<front><div type="abstract" xml:lang="en">Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronized oscillatory activity. To explore this we recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse-width 60µs; frequency 130 Hz) of the same target using a specially designed amplifier. We analyzed data from 25 sides and found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54 % of baseline values by a stimulation intensity of 3.0 V. The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div>
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<front><div type="abstract">Background Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity. Methods To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides. Results The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V. Conclusion The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div>
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<author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name>
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<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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</author>
<author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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</author>
<author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Oxford</settlement>
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<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
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<author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
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<idno type="pmid">20935326</idno>
<idno type="pmc">3072048</idno>
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<idno type="RBID">PMC:3072048</idno>
<idno type="doi">10.1136/jnnp.2010.217489</idno>
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<idno type="wicri:doubleKey">0022-3050:2010:Eusebio A:deep:brain:stimulation</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title>
<author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurology and Movement Disorders, Timone University Hospital, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name>
<affiliation wicri:level="3"><nlm:aff id="aff4">Neurosurgery, King's College Hospital, Denmark Hill, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name>
<affiliation wicri:level="3"><nlm:aff id="aff5">Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<idno type="eISSN">1468-330X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.</p>
</sec>
<sec><title>Methods</title>
<p>To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.</p>
</sec>
<sec><title>Results</title>
<p>The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.</p>
</sec>
<sec><title>Conclusion</title>
<p>The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</p>
</sec>
</div>
</front>
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