ParkinsonFranceV1, Hal, Corpus, bibRecord, 000255

Deep Brain Stimulation can suppress pathological synchronization in parkinsonian patients

Identifieur interne : 000255 ( Hal/Corpus ); précédent : 000254; suivant : 000256

Deep Brain Stimulation can suppress pathological synchronization in parkinsonian patients

Auteurs : Alexandre Eusebio ; Wesley Thevathasan ; Louise Doyle Gaynor ; Alek Pogosyan ; Ed Bye ; Tom Foltynie ; Ludvic Zrinzo ; Keymour Ashkan ; Tipu Aziz ; Peter Brown

Source :

Journal of Neurology, Neurosurgery and Psychiatry [ 0022-3050 ] ; 2010-10-09.

RBID : Hal:hal-00585779

English descriptors

mix :
- ELECTRICAL STIMULATION, MOTOR, MOTOR PHYSIOLOGY, MOVEMENT DISORDERS, NEUROPHYSIOLOGY, PARKINSON'S DISEASE.

Abstract

Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronized oscillatory activity. To explore this we recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse-width 60µs; frequency 130 Hz) of the same target using a specially designed amplifier. We analyzed data from 25 sides and found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54 % of baseline values by a stimulation intensity of 3.0 V. The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.

Url:

https://hal.archives-ouvertes.fr/hal-00585779

DOI: 10.1136/jnnp.2010.217489

Links to Exploration step

Hal:hal-00585779

Le document en format XML

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<front><div type="abstract" xml:lang="en">Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronized oscillatory activity. To explore this we recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse-width 60µs; frequency 130 Hz) of the same target using a specially designed amplifier. We analyzed data from 25 sides and found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54 % of baseline values by a stimulation intensity of 3.0 V. The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</div>
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            <idno type="halRefHtml">Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2010, 82 (5), pp.569. <10.1136/jnnp.2010.217489></idno>
            <idno type="halRef">Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2010, 82 (5), pp.569. <10.1136/jnnp.2010.217489></idno>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Deep Brain Stimulation can suppress pathological synchronization in parkinsonian patients</title>
                <author role="aut">                  <persName>                    <forename type="first">Alexandre</forename>
                    <surname>Eusebio</surname>
                  </persName>
                  <email type="md5">86fa68093c3aebe523e295f6b2f9eed5</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="halauthorid">600241</idno>
                  <affiliation ref="#struct-300093"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Wesley</forename>
                    <surname>Thevathasan</surname>
                  </persName>
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                  <email type="domain">ion.ucl.ac.uk</email>
                  <idno type="halauthorid">600242</idno>
                  <affiliation ref="#struct-218831"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Louise</forename>
                    <surname>Doyle Gaynor</surname>
                  </persName>
                  <email type="md5">cb1bf6c34cce78f8b71cbcd5d016f233</email>
                  <email type="domain">ucl.ac.uk</email>
                  <idno type="halauthorid">600243</idno>
                  <affiliation ref="#struct-300875"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Alek</forename>
                    <surname>Pogosyan</surname>
                  </persName>
                  <email type="md5">5fc61acfb26dd7b4188a67d4306a28e6</email>
                  <email type="domain">ion.ucl.ac.uk</email>
                  <idno type="halauthorid">600244</idno>
                  <affiliation ref="#struct-300875"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Ed</forename>
                    <surname>Bye</surname>
                  </persName>
                  <email type="md5">d7bb421378a0c454b3ac33e09ac2c477</email>
                  <email type="domain">ion.ucl.ac.uk</email>
                  <idno type="halauthorid">600245</idno>
                  <affiliation ref="#struct-300875"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Tom</forename>
                    <surname>Foltynie</surname>
                  </persName>
                  <email type="md5">ffb1a0e59f2136a098b27f49d9d70fe1</email>
                  <email type="domain">ion.ucl.ac.uk</email>
                  <idno type="halauthorid">600246</idno>
                  <affiliation ref="#struct-300875"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Ludvic</forename>
                    <surname>Zrinzo</surname>
                  </persName>
                  <email type="md5">9dcde2a2f8a672af1675d30fc03fa500</email>
                  <email type="domain">ion.ucl.ac.uk</email>
                  <idno type="halauthorid">591647</idno>
                  <affiliation ref="#struct-300875"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Keymour</forename>
                    <surname>Ashkan</surname>
                  </persName>
                  <email type="md5">c8db83a370d107306fcabdba719283a0</email>
                  <email type="domain">kch.nhs.uk</email>
                  <idno type="halauthorid">600247</idno>
                  <affiliation ref="#struct-152917"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Tipu</forename>
                    <surname>Aziz</surname>
                  </persName>
                  <email type="md5">194c5753542d3ac2556a55e6be29f646</email>
                  <email type="domain">dpag.ox.ac.uk</email>
                  <idno type="halauthorid">600248</idno>
                  <affiliation ref="#struct-218831"></affiliation>
                </author>
                <author role="crp">                  <persName>                    <forename type="first">Peter</forename>
                    <surname>Brown</surname>
                  </persName>
                  <email type="md5">86fa68093c3aebe523e295f6b2f9eed5</email>
                  <email type="domain">ap-hm.fr</email>
                  <idno type="halauthorid">600249</idno>
                  <affiliation ref="#struct-16095"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">15872</idno>
                <idno type="issn">0022-3050</idno>
                <idno type="eissn">1468-330X</idno>
                <title level="j">Journal of Neurology, Neurosurgery and Psychiatry</title>
                <imprint>                  <publisher>BMJ Publishing Group</publisher>
                  <biblScope unit="volume">82</biblScope>
                  <biblScope unit="issue">5</biblScope>
                  <biblScope unit="pp">569</biblScope>
                  <date type="datePub">2010-10-09</date>
                </imprint>
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              <idno type="doi">10.1136/jnnp.2010.217489</idno>
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          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="en">ELECTRICAL STIMULATION</term>
                <term xml:lang="en">MOTOR PHYSIOLOGY</term>
                <term xml:lang="en">MOVEMENT DISORDERS</term>
                <term xml:lang="en">NEUROPHYSIOLOGY</term>
                <term xml:lang="en">MOTOR</term>
                <term xml:lang="en">PARKINSON'S DISEASE</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronized oscillatory activity. To explore this we recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse-width 60µs; frequency 130 Hz) of the same target using a specially designed amplifier. We analyzed data from 25 sides and found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54 % of baseline values by a stimulation intensity of 3.0 V. The findings suggest that DBS can suppress pathological 11-30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</abstract>
          </profileDesc>
        </hal>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Deep Brain Stimulation can suppress pathological synchronization in parkinsonian patients

Deep Brain Stimulation can suppress pathological synchronization in parkinsonian patients

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