Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
Identifieur interne : 000767 ( Pmc/Checkpoint ); précédent : 000766; suivant : 000768Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
Auteurs : A. Eusebio [Royaume-Uni, France] ; W. Thevathasan [Royaume-Uni] ; L. Doyle Gaynor [Royaume-Uni] ; A. Pogosyan [Royaume-Uni] ; E. Bye [Royaume-Uni] ; T. Foltynie [Royaume-Uni] ; L. Zrinzo [Royaume-Uni] ; K. Ashkan [Royaume-Uni] ; T. Aziz [Royaume-Uni] ; P. Brown [Royaume-Uni]Source :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 2010.
Abstract
Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.
To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.
The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.
The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.
Url:
DOI: 10.1136/jnnp.2010.217489
PubMed: 20935326
PubMed Central: 3072048
Affiliations:
- France, Royaume-Uni
- Angleterre, Grand Londres, Oxfordshire, Provence-Alpes-Côte d'Azur
- Londres, Marseille, Oxford
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3072048Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title><author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurology and Movement Disorders, Timone University Hospital, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><nlm:aff id="aff4">Neurosurgery, King's College Hospital, Denmark Hill, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20935326</idno><idno type="pmc">3072048</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072048</idno><idno type="RBID">PMC:3072048</idno><idno type="doi">10.1136/jnnp.2010.217489</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000775</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000775</idno><idno type="wicri:Area/Pmc/Curation">000772</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000772</idno><idno type="wicri:Area/Pmc/Checkpoint">000767</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000767</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</title><author><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Department of Neurology and Movement Disorders, Timone University Hospital, Marseille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><affiliation wicri:level="3"><nlm:aff id="aff4">Neurosurgery, King's College Hospital, Denmark Hill, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurosurgery, King's College Hospital, Denmark Hill, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><affiliation wicri:level="3"><nlm:aff id="aff5">Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Neurological Surgery, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><affiliation wicri:level="3"><nlm:aff id="aff1">Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3">Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Neurology, John Radcliffe Hospital, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.</p></sec><sec><title>Methods</title><p>To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.</p></sec><sec><title>Results</title><p>The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.</p></sec><sec><title>Conclusion</title><p>The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hammond, C" uniqKey="Hammond C">C Hammond</name></author><author><name sortKey="Ammari, R" uniqKey="Ammari R">R Ammari</name></author><author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B Bioulac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, P" uniqKey="Brown P">P Brown</name></author><author><name sortKey="Eusebio, A" uniqKey="Eusebio A">A Eusebio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gatev, P" uniqKey="Gatev P">P Gatev</name></author><author><name sortKey="Darbin, O" uniqKey="Darbin O">O Darbin</name></author><author><name sortKey="Wichmann, T" uniqKey="Wichmann T">T Wichmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammond, C" uniqKey="Hammond C">C Hammond</name></author><author><name sortKey="Bergman, H" uniqKey="Bergman H">H Bergman</name></author><author><name sortKey="Brown, P" uniqKey="Brown P">P Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uhlhaas, Pj" uniqKey="Uhlhaas P">PJ Uhlhaas</name></author><author><name sortKey="Singer, W" uniqKey="Singer W">W Singer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberger, M" uniqKey="Weinberger M">M Weinberger</name></author><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author><author><name sortKey="Dostrovsky, J" uniqKey="Dostrovsky J">J Dostrovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, L" uniqKey="Rossi L">L Rossi</name></author><author><name sortKey="Foffani, G" uniqKey="Foffani G">G Foffani</name></author><author><name sortKey="Marceglia, S" uniqKey="Marceglia S">S Marceglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bronte Stewart, H" uniqKey="Bronte Stewart H">H Bronte-Stewart</name></author><author><name sortKey="Barberini, C" uniqKey="Barberini C">C Barberini</name></author><author><name sortKey="Koop, Mm" uniqKey="Koop M">MM Koop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, P" uniqKey="Brown P">P Brown</name></author><author><name sortKey="Mazzone, P" uniqKey="Mazzone P">P Mazzone</name></author><author><name sortKey="Oliviero, A" uniqKey="Oliviero A">A Oliviero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kuhn</name></author><author><name sortKey="Kempf, F" uniqKey="Kempf F">F Kempf</name></author><author><name sortKey="Brucke, C" uniqKey="Brucke C">C Brucke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silberstein, P" uniqKey="Silberstein P">P Silberstein</name></author><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kuhn</name></author><author><name sortKey="Kupsch, A" uniqKey="Kupsch A">A Kupsch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wingeier, B" uniqKey="Wingeier B">B Wingeier</name></author><author><name sortKey="Tcheng, T" uniqKey="Tcheng T">T Tcheng</name></author><author><name sortKey="Koop, Mm" uniqKey="Koop M">MM Koop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foffani, G" uniqKey="Foffani G">G Foffani</name></author><author><name sortKey="Ardolino, G" uniqKey="Ardolino G">G Ardolino</name></author><author><name sortKey="Egidi, M" uniqKey="Egidi M">M Egidi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossi, L" uniqKey="Rossi L">L Rossi</name></author><author><name sortKey="Marceglia, S" uniqKey="Marceglia S">S Marceglia</name></author><author><name sortKey="Foffani, G" uniqKey="Foffani G">G Foffani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Cc" uniqKey="Chen C">CC Chen</name></author><author><name sortKey="Pogosyan, A" uniqKey="Pogosyan A">A Pogosyan</name></author><author><name sortKey="Zrinzo, Lu" uniqKey="Zrinzo L">LU Zrinzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alonso Frech, F" uniqKey="Alonso Frech F">F Alonso-Frech</name></author><author><name sortKey="Zamarbide, I" uniqKey="Zamarbide I">I Zamarbide</name></author><author><name sortKey="Alegre, M" uniqKey="Alegre M">M Alegre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Devos, D" uniqKey="Devos D">D Devos</name></author><author><name sortKey="Szurhaj, W" uniqKey="Szurhaj W">W Szurhaj</name></author><author><name sortKey="Reyns, N" uniqKey="Reyns N">N Reyns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miyagi, Y" uniqKey="Miyagi Y">Y Miyagi</name></author><author><name sortKey="Okamoto, T" uniqKey="Okamoto T">T Okamoto</name></author><author><name sortKey="Morioka, T" uniqKey="Morioka T">T Morioka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshida, F" uniqKey="Yoshida F">F Yoshida</name></author><author><name sortKey="Martinez Torres, I" uniqKey="Martinez Torres I">I Martinez-Torres</name></author><author><name sortKey="Pogosyan, A" uniqKey="Pogosyan A">A Pogosyan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Priori, A" uniqKey="Priori A">A Priori</name></author><author><name sortKey="Foffani, G" uniqKey="Foffani G">G Foffani</name></author><author><name sortKey="Pesenti, A" uniqKey="Pesenti A">A Pesenti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Priori, A" uniqKey="Priori A">A Priori</name></author><author><name sortKey="Foffani, G" uniqKey="Foffani G">G Foffani</name></author><author><name sortKey="Pesenti, A" uniqKey="Pesenti A">A Pesenti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, D" uniqKey="Williams D">D Williams</name></author><author><name sortKey="Tijssen, M" uniqKey="Tijssen M">M Tijssen</name></author><author><name sortKey="Van Bruggen, G" uniqKey="Van Bruggen G">G Van Bruggen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Foffani, G" uniqKey="Foffani G">G Foffani</name></author><author><name sortKey="Bianchi, Am" uniqKey="Bianchi A">AM Bianchi</name></author><author><name sortKey="Baselli, G" uniqKey="Baselli G">G Baselli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Curran Everett, D" uniqKey="Curran Everett D">D Curran-Everett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kühn</name></author><author><name sortKey="Brucke, C" uniqKey="Brucke C">C Brücke</name></author><author><name sortKey="Schneider, G H" uniqKey="Schneider G">G-H Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ecceles, Jc" uniqKey="Ecceles J">JC Ecceles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Logothetis, Nk" uniqKey="Logothetis N">NK Logothetis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fogelson, N" uniqKey="Fogelson N">N Fogelson</name></author><author><name sortKey="Williams, D" uniqKey="Williams D">D Williams</name></author><author><name sortKey="Tijssen, M" uniqKey="Tijssen M">M Tijssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lalo, E" uniqKey="Lalo E">E Lalo</name></author><author><name sortKey="Thobois, S" uniqKey="Thobois S">S Thobois</name></author><author><name sortKey="Sharott, A" uniqKey="Sharott A">A Sharott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gradinaru, V" uniqKey="Gradinaru V">V Gradinaru</name></author><author><name sortKey="Mogri, M" uniqKey="Mogri M">M Mogri</name></author><author><name sortKey="Thompson, Kr" uniqKey="Thompson K">KR Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dorval, Ad" uniqKey="Dorval A">AD Dorval</name></author><author><name sortKey="Russo, Gs" uniqKey="Russo G">GS Russo</name></author><author><name sortKey="Hashimoto, T" uniqKey="Hashimoto T">T Hashimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montgomery, Ebj" uniqKey="Montgomery E">EBJ Montgomery</name></author><author><name sortKey="Gale, Jt" uniqKey="Gale J">JT Gale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia, L" uniqKey="Garcia L">L Garcia</name></author><author><name sortKey="D Alessandro, G" uniqKey="D Alessandro G">G D'Alessandro</name></author><author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B Bioulac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashimoto, T" uniqKey="Hashimoto T">T Hashimoto</name></author><author><name sortKey="Elder, Cm" uniqKey="Elder C">CM Elder</name></author><author><name sortKey="Okun, Ms" uniqKey="Okun M">MS Okun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maurice, N" uniqKey="Maurice N">N Maurice</name></author><author><name sortKey="Thierry, Am" uniqKey="Thierry A">AM Thierry</name></author><author><name sortKey="Glowinski, J" uniqKey="Glowinski J">J Glowinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilker, R" uniqKey="Hilker R">R Hilker</name></author><author><name sortKey="Voges, J" uniqKey="Voges J">J Voges</name></author><author><name sortKey="Weber, T" uniqKey="Weber T">T Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koop, Mm" uniqKey="Koop M">MM Koop</name></author><author><name sortKey="Andrzejewski, A" uniqKey="Andrzejewski A">A Andrzejewski</name></author><author><name sortKey="Hill, Bc" uniqKey="Hill B">BC Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosa, M" uniqKey="Rosa M">M Rosa</name></author><author><name sortKey="Marceglia, S" uniqKey="Marceglia S">S Marceglia</name></author><author><name sortKey="Servello, D" uniqKey="Servello D">D Servello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kuhn</name></author><author><name sortKey="Kupsch, A" uniqKey="Kupsch A">A Kupsch</name></author><author><name sortKey="Schneider, Gh" uniqKey="Schneider G">GH Schneider</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kuhn</name></author><author><name sortKey="Tsui, A" uniqKey="Tsui A">A Tsui</name></author><author><name sortKey="Aziz, T" uniqKey="Aziz T">T Aziz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ray, Nj" uniqKey="Ray N">NJ Ray</name></author><author><name sortKey="Jenkinson, N" uniqKey="Jenkinson N">N Jenkinson</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuhn, Aa" uniqKey="Kuhn A">AA Kühn</name></author><author><name sortKey="Trottenberg, T" uniqKey="Trottenberg T">T Trottenberg</name></author><author><name sortKey="Kivi, A" uniqKey="Kivi A">A Kivi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaidel, A" uniqKey="Zaidel A">A Zaidel</name></author><author><name sortKey="Spivak, A" uniqKey="Spivak A">A Spivak</name></author><author><name sortKey="Grieb, B" uniqKey="Grieb B">B Grieb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saint Cyr, Ja" uniqKey="Saint Cyr J">JA Saint-Cyr</name></author><author><name sortKey="Hoque, T" uniqKey="Hoque T">T Hoque</name></author><author><name sortKey="Pereira, Lc" uniqKey="Pereira L">LC Pereira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voges, J" uniqKey="Voges J">J Voges</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author><author><name sortKey="Allert, N" uniqKey="Allert N">N Allert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plaha, P" uniqKey="Plaha P">P Plaha</name></author><author><name sortKey="Ben Shlomo, Y" uniqKey="Ben Shlomo Y">Y Ben-Shlomo</name></author><author><name sortKey="Patel, Nk" uniqKey="Patel N">NK Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moro, E" uniqKey="Moro E">E Moro</name></author><author><name sortKey="Esselink, Rj" uniqKey="Esselink R">RJ Esselink</name></author><author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, R" uniqKey="Levy R">R Levy</name></author><author><name sortKey="Ashby, P" uniqKey="Ashby P">P Ashby</name></author><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberger, M" uniqKey="Weinberger M">M Weinberger</name></author><author><name sortKey="Mahant, N" uniqKey="Mahant N">N Mahant</name></author><author><name sortKey="Hutchison, Wd" uniqKey="Hutchison W">WD Hutchison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stanslaski, S" uniqKey="Stanslaski S">S Stanslaski</name></author><author><name sortKey="Cong, P" uniqKey="Cong P">P Cong</name></author><author><name sortKey="Carlson, D" uniqKey="Carlson D">D Carlson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Cc" uniqKey="Chen C">CC Chen</name></author><author><name sortKey="Hsu, Yt" uniqKey="Hsu Y">YT Hsu</name></author><author><name sortKey="Chan, Hl" uniqKey="Chan H">HL Chan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-id journal-id-type="publisher-id">jnnp</journal-id><journal-id journal-id-type="hwp">jnnp</journal-id><journal-title-group><journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title></journal-title-group><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20935326</article-id><article-id pub-id-type="pmc">3072048</article-id><article-id pub-id-type="publisher-id">jnnp217489</article-id><article-id pub-id-type="doi">10.1136/jnnp.2010.217489</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject></subj-group></article-categories><title-group><article-title>Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Eusebio</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Thevathasan</surname><given-names>W</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Doyle Gaynor</surname><given-names>L</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pogosyan</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Bye</surname><given-names>E</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Foltynie</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zrinzo</surname><given-names>L</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ashkan</surname><given-names>K</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Aziz</surname><given-names>T</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Brown</surname><given-names>P</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK</aff><aff id="aff2"><label>2</label>Department of Neurology and Movement Disorders, Timone University Hospital, Marseille, France</aff><aff id="aff3"><label>3</label>Department of Clinical Neurology, John Radcliffe Hospital, Oxford, UK</aff><aff id="aff4"><label>4</label>Neurosurgery, King's College Hospital, Denmark Hill, London, UK</aff><aff id="aff5"><label>5</label>Department of Neurological Surgery, John Radcliffe Hospital, Oxford, UK</aff><author-notes><corresp><label>Correspondence to</label> Professor P Brown, Department of Clinical Neurology, John Radcliffe Hospital, Oxford OX3 9DU, UK; <email>peter.brown@clneuro.ox.ac.uk</email></corresp><fn fn-type="other"><p>P Brown holds a consultancy with Medtronic Inc.</p></fn></author-notes><pub-date pub-type="epub"><day>9</day><month>10</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2011</year></pub-date><volume>82</volume><issue>5</issue><fpage>569</fpage><lpage>573</lpage><history><date date-type="received"><day>19</day><month>5</month><year>2010</year></date><date date-type="rev-recd"><day>27</day><month>8</month><year>2010</year></date><date date-type="accepted"><day>2</day><month>9</month><year>2010</year></date></history><permissions><copyright-statement>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2011</copyright-year><license license-type="open-access"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/">http://creativecommons.org/licenses/by-nc/2.0/</ext-link> and <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/2.0/legalcode">http://creativecommons.org/licenses/by-nc/2.0/legalcode</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="jnnp217489.pdf"></self-uri><abstract><sec><title>Background</title><p>Although deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effective therapeutic intervention in severe Parkinson's disease, its mechanism of action remains unclear. One possibility is that DBS suppresses local pathologically synchronised oscillatory activity.</p></sec><sec><title>Methods</title><p>To explore this, the authors recorded from DBS electrodes implanted in the STN of 16 patients with Parkinson's disease during simultaneous stimulation (pulse width 60 μs; frequency 130 Hz) of the same target using a specially designed amplifier. The authors analysed data from 25 sides.</p></sec><sec><title>Results</title><p>The authors found that DBS progressively suppressed peaks in local field potential activity at frequencies between 11 and 30 Hz as voltage was increased beyond a stimulation threshold of 1.5 V. Median peak power had fallen to 54% of baseline values by a stimulation intensity of 3.0 V.</p></sec><sec><title>Conclusion</title><p>The findings suggest that DBS can suppress pathological 11–30 Hz activity in the vicinity of stimulation in patients with Parkinson's disease. This suppression occurs at stimulation voltages that are clinically effective.</p></sec></abstract><kwd-group><kwd>Parkinson's disease</kwd><kwd>basal ganglia</kwd><kwd>deep brain stimulation</kwd><kwd>oscillations</kwd><kwd>neurophysiology</kwd><kwd>electrical stimulation</kwd><kwd>motor physiology</kwd><kwd>movement disorders</kwd><kwd>motor</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Oxfordshire</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Londres</li><li>Marseille</li><li>Oxford</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name></region><name sortKey="Ashkan, K" sort="Ashkan, K" uniqKey="Ashkan K" first="K" last="Ashkan">K. Ashkan</name><name sortKey="Aziz, T" sort="Aziz, T" uniqKey="Aziz T" first="T" last="Aziz">T. Aziz</name><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><name sortKey="Brown, P" sort="Brown, P" uniqKey="Brown P" first="P" last="Brown">P. Brown</name><name sortKey="Bye, E" sort="Bye, E" uniqKey="Bye E" first="E" last="Bye">E. Bye</name><name sortKey="Doyle Gaynor, L" sort="Doyle Gaynor, L" uniqKey="Doyle Gaynor L" first="L" last="Doyle Gaynor">L. Doyle Gaynor</name><name sortKey="Foltynie, T" sort="Foltynie, T" uniqKey="Foltynie T" first="T" last="Foltynie">T. Foltynie</name><name sortKey="Pogosyan, A" sort="Pogosyan, A" uniqKey="Pogosyan A" first="A" last="Pogosyan">A. Pogosyan</name><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><name sortKey="Thevathasan, W" sort="Thevathasan, W" uniqKey="Thevathasan W" first="W" last="Thevathasan">W. Thevathasan</name><name sortKey="Zrinzo, L" sort="Zrinzo, L" uniqKey="Zrinzo L" first="L" last="Zrinzo">L. Zrinzo</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Eusebio, A" sort="Eusebio, A" uniqKey="Eusebio A" first="A" last="Eusebio">A. Eusebio</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000767 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000767 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:3072048
|texte= Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:20935326" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |