Gait and attentional performance in freezers under methylphenidate.
Identifieur interne : 000628 ( Main/Exploration ); précédent : 000627; suivant : 000629Gait and attentional performance in freezers under methylphenidate.
Auteurs : A. Delval [France] ; C. Moreau [France] ; S. Bleuse [France] ; D. Guehl [France] ; E. Bestaven [France] ; E. Guillaud [France] ; K. Dujardin [France] ; L. Defebvre [France] ; D. Devos [France]Source :
- Gait & posture [ 1879-2219 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Dopamine Uptake Inhibitors, Methylphenidate.
- complications : Parkinson Disease.
- drug effects : Attention.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Attentional resources appear to be involved in the occurrence of FoG. The Parkgait study recently reported that methylphenidate reduces gait hypokinesia and freezing of gait (FoG) in advanced PD patients receiving STN-DBS in the off-dopaminergic drug condition. Methylphenidate is considered to improve attention. The primary objective of the present ancillary study was to determine whether methylphenidate reduced the interference between a cognitive task and gait in patients with FoG. The study's secondary objective was to compare attentional performance in methylphenidate-treated and placebo-treated patients.
DOI: 10.1016/j.gaitpost.2014.10.022
PubMed: 25468682
Affiliations:
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Le document en format XML
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Delval</name><affiliation wicri:level="1"><nlm:affiliation>Lille University, France; EA 1046, Department of Clinical Neurophysiology, Lille University Medical Center, France. Electronic address: arnaud.delval@chru-lille.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lille University, France; EA 1046, Department of Clinical Neurophysiology, Lille University Medical Center</wicri:regionArea><wicri:noRegion>Lille University Medical Center</wicri:noRegion><wicri:noRegion>Lille University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Moreau, C" sort="Moreau, C" uniqKey="Moreau C" first="C" last="Moreau">C. Moreau</name><affiliation wicri:level="1"><nlm:affiliation>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center</wicri:regionArea><wicri:noRegion>Lille University Medical Center</wicri:noRegion><wicri:noRegion>Lille University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Bleuse, S" sort="Bleuse, S" uniqKey="Bleuse S" first="S" last="Bleuse">S. Bleuse</name><affiliation wicri:level="1"><nlm:affiliation>Lille University, France; EA 1046, Department of Clinical Neurophysiology, Lille University Medical Center, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lille University, France; EA 1046, Department of Clinical Neurophysiology, Lille University Medical Center</wicri:regionArea><wicri:noRegion>Lille University Medical Center</wicri:noRegion><wicri:noRegion>Lille University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name><affiliation wicri:level="3"><nlm:affiliation>Bordeaux 2 University, UMR 5293, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux 2 University, UMR 5293, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bestaven, E" sort="Bestaven, E" uniqKey="Bestaven E" first="E" last="Bestaven">E. Bestaven</name><affiliation wicri:level="3"><nlm:affiliation>Bordeaux 2 University, UMR 5293, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux 2 University, UMR 5293, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Guillaud, E" sort="Guillaud, E" uniqKey="Guillaud E" first="E" last="Guillaud">E. Guillaud</name><affiliation wicri:level="3"><nlm:affiliation>Bordeaux 2 University, UMR 5293, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Bordeaux 2 University, UMR 5293, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name><affiliation wicri:level="1"><nlm:affiliation>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center</wicri:regionArea><wicri:noRegion>Lille University Medical Center</wicri:noRegion><wicri:noRegion>Lille University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><affiliation wicri:level="1"><nlm:affiliation>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center</wicri:regionArea><wicri:noRegion>Lille University Medical Center</wicri:noRegion><wicri:noRegion>Lille University Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Devos, D" sort="Devos, D" uniqKey="Devos D" first="D" last="Devos">D. Devos</name><affiliation wicri:level="1"><nlm:affiliation>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center, France; EA 1046, Department of Pharmacology, Lille University Medical Center, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Lille University, France; EA 1046, Department of Neurology and Movement Disorders, Lille University Medical Center, France; EA 1046, Department of Pharmacology, Lille University Medical Center</wicri:regionArea><wicri:noRegion>Lille University Medical Center</wicri:noRegion><wicri:noRegion>Lille University Medical Center</wicri:noRegion></affiliation></author></analytic><series><title level="j">Gait & posture</title><idno type="eISSN">1879-2219</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Attention (drug effects)</term><term>Dopamine Uptake Inhibitors (therapeutic use)</term><term>Female</term><term>Gait Disorders, Neurologic (drug therapy)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Male</term><term>Methylphenidate (therapeutic use)</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Uptake Inhibitors</term><term>Methylphenidate</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Attention</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Attentional resources appear to be involved in the occurrence of FoG. The Parkgait study recently reported that methylphenidate reduces gait hypokinesia and freezing of gait (FoG) in advanced PD patients receiving STN-DBS in the off-dopaminergic drug condition. Methylphenidate is considered to improve attention. The primary objective of the present ancillary study was to determine whether methylphenidate reduced the interference between a cognitive task and gait in patients with FoG. The study's secondary objective was to compare attentional performance in methylphenidate-treated and placebo-treated patients.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Delval, A" sort="Delval, A" uniqKey="Delval A" first="A" last="Delval">A. Delval</name></noRegion><name sortKey="Bestaven, E" sort="Bestaven, E" uniqKey="Bestaven E" first="E" last="Bestaven">E. Bestaven</name><name sortKey="Bleuse, S" sort="Bleuse, S" uniqKey="Bleuse S" first="S" last="Bleuse">S. Bleuse</name><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name><name sortKey="Devos, D" sort="Devos, D" uniqKey="Devos D" first="D" last="Devos">D. Devos</name><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name><name sortKey="Guillaud, E" sort="Guillaud, E" uniqKey="Guillaud E" first="E" last="Guillaud">E. Guillaud</name><name sortKey="Moreau, C" sort="Moreau, C" uniqKey="Moreau C" first="C" last="Moreau">C. Moreau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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