Gait and attentional performance in freezers under methylphenidate.
Identifieur interne : 000631 ( Main/Merge ); précédent : 000630; suivant : 000632Gait and attentional performance in freezers under methylphenidate.
Auteurs : A. Delval [France] ; C. Moreau [France] ; S. Bleuse [France] ; D. Guehl [France] ; E. Bestaven [France] ; E. Guillaud [France] ; K. Dujardin [France] ; L. Defebvre [France] ; D. Devos [France]Source :
- Gait & posture [ 1879-2219 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Dopamine Uptake Inhibitors, Methylphenidate.
- complications : Parkinson Disease.
- drug effects : Attention.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Attentional resources appear to be involved in the occurrence of FoG. The Parkgait study recently reported that methylphenidate reduces gait hypokinesia and freezing of gait (FoG) in advanced PD patients receiving STN-DBS in the off-dopaminergic drug condition. Methylphenidate is considered to improve attention. The primary objective of the present ancillary study was to determine whether methylphenidate reduced the interference between a cognitive task and gait in patients with FoG. The study's secondary objective was to compare attentional performance in methylphenidate-treated and placebo-treated patients.
DOI: 10.1016/j.gaitpost.2014.10.022
PubMed: 25468682
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pubmed:25468682Le document en format XML
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<term>Gait Disorders, Neurologic (drug therapy)</term>
<term>Gait Disorders, Neurologic (etiology)</term>
<term>Humans</term>
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<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">Attentional resources appear to be involved in the occurrence of FoG. The Parkgait study recently reported that methylphenidate reduces gait hypokinesia and freezing of gait (FoG) in advanced PD patients receiving STN-DBS in the off-dopaminergic drug condition. Methylphenidate is considered to improve attention. The primary objective of the present ancillary study was to determine whether methylphenidate reduced the interference between a cognitive task and gait in patients with FoG. The study's secondary objective was to compare attentional performance in methylphenidate-treated and placebo-treated patients.</div>
</front>
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