Cognitive disorders in Parkinson's disease: Confirmation of a spectrum of severity.
Identifieur interne : 000394 ( PubMed/Checkpoint ); précédent : 000393; suivant : 000395Cognitive disorders in Parkinson's disease: Confirmation of a spectrum of severity.
Auteurs : Kathy Dujardin [France] ; Anja J H. Moonen [Pays-Bas] ; Hélène Behal [France] ; Luc Defebvre [France] ; Alain Duhamel [France] ; Annelien A. Duits [Pays-Bas] ; Lucie Plomhause [France] ; Celine Tard [France] ; Albert F G. Leentjens [Pays-Bas]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Cluster Analysis, Cognition Disorders (etiology), Cognition Disorders (physiopathology), Executive Function (physiology), Female, Humans, Male, Memory Disorders (etiology), Memory Disorders (physiopathology), Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (physiopathology), Severity of Illness Index.
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Memory Disorders.
- physiology : Executive Function.
- physiopathology : Cognition Disorders, Memory Disorders, Parkinson Disease.
- Aged, Cluster Analysis, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
Clinical presentation and progression of cognitive disorders in Parkinson's disease (PD) is heterogeneous. Our objective was to confirm prospectively a previous exploratory cluster analysis based on retrospective data that identified five cognitive phenotypes in PD.
DOI: 10.1016/j.parkreldis.2015.08.032
PubMed: 26350121
Affiliations:
- France, Pays-Bas
- Hauts-de-France, Nord-Pas-de-Calais
- Lille
- Université Lille 2, Université Lille Nord de France
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:26350121Le document en format XML
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Electronic address: alain.duhamel@univ-lille2.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duits, Annelien A" sort="Duits, Annelien A" uniqKey="Duits A" first="Annelien A" last="Duits">Annelien A. Duits</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: annelien.duits@maastrichtuniversity.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Plomhause, Lucie" sort="Plomhause, Lucie" uniqKey="Plomhause L" first="Lucie" last="Plomhause">Lucie Plomhause</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France. Electronic address: lucie.plomhause@chru-lille.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Tard, Celine" sort="Tard, Celine" uniqKey="Tard C" first="Celine" last="Tard">Celine Tard</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France. 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Electronic address: kathy.dujardin@univ-lille2.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J H" last="Moonen">Anja J H. Moonen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: anja.moonen@maastrichtuniversity.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Behal, Helene" sort="Behal, Helene" uniqKey="Behal H" first="Hélène" last="Behal">Hélène Behal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biostatistics, Lille University Medical Center, Lille, France. Electronic address: hbehalchr@gmail.com.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France. Electronic address: luc.defebvre@chru-lille.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Biostatistics, Lille University Medical Center, Lille, France. Electronic address: alain.duhamel@univ-lille2.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Biostatistics, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duits, Annelien A" sort="Duits, Annelien A" uniqKey="Duits A" first="Annelien A" last="Duits">Annelien A. Duits</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: annelien.duits@maastrichtuniversity.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Plomhause, Lucie" sort="Plomhause, Lucie" uniqKey="Plomhause L" first="Lucie" last="Plomhause">Lucie Plomhause</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France. Electronic address: lucie.plomhause@chru-lille.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Tard, Celine" sort="Tard, Celine" uniqKey="Tard C" first="Celine" last="Tard">Celine Tard</name><affiliation wicri:level="3"><nlm:affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France. Electronic address: celine.tard@chru-lille.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F G" last="Leentjens">Albert F G. Leentjens</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: a.leentjens@maastrichtuniversity.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Maastricht University Medical Center, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cluster Analysis</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (physiopathology)</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Memory Disorders (etiology)</term><term>Memory Disorders (physiopathology)</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Memory Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Executive Function</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Cognition Disorders</term><term>Memory Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cluster Analysis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical presentation and progression of cognitive disorders in Parkinson's disease (PD) is heterogeneous. Our objective was to confirm prospectively a previous exploratory cluster analysis based on retrospective data that identified five cognitive phenotypes in PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26350121</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>03</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>06</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>11</Issue><PubDate><Year>2015</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Cognitive disorders in Parkinson's disease: Confirmation of a spectrum of severity.</ArticleTitle><Pagination><MedlinePgn>1299-305</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2015.08.032</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(15)00371-5</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Clinical presentation and progression of cognitive disorders in Parkinson's disease (PD) is heterogeneous. Our objective was to confirm prospectively a previous exploratory cluster analysis based on retrospective data that identified five cognitive phenotypes in PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A model-based confirmatory cluster analysis was conducted on the results of neuropsychological tests administered in 156 PD patients from two European movement disorder centers (Lille, n = 81; Maastricht, n = 75). The number of clusters was determined on the basis of statistical criteria as well as clinical plausibility. A factorial discriminant analysis assessed the quality of the clusters' separation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A five-cluster model was statistically superior and clinically the most relevant. These clusters can be described as follows: 1) cognitively intact patients with high level of performance in all cognitive domains (25.64%), 2) cognitively intact patients slightly slower than those in cluster 1 (26.92%), 3) patients with deficits in executive functions (37.18%), 4) patients with severe deficits in all cognitive domains, particularly executive functions (3.20%), 5) patients with severe deficits in all cognitive domains, particularly working memory and recall in verbal episodic memory (7.05%). The groups differed in terms of age, apathy and frequency of hallucinations that were all higher in the clusters with cognitive deficits, and the duration of formal education was lower in those groups.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We confirm our previous exploratory analysis. Cognitive disorders in PD patients are heterogeneous and can be separated in five clusters ranging from patients with performance in the normal range to patients with severe disorders in all cognitive domains.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dujardin</LastName><ForeName>Kathy</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France. Electronic address: kathy.dujardin@univ-lille2.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moonen</LastName><ForeName>Anja J H</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: anja.moonen@maastrichtuniversity.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Behal</LastName><ForeName>Hélène</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Lille University Medical Center, Lille, France. Electronic address: hbehalchr@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>Luc</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France. Electronic address: luc.defebvre@chru-lille.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duhamel</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Lille University Medical Center, Lille, France. Electronic address: alain.duhamel@univ-lille2.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duits</LastName><ForeName>Annelien A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: annelien.duits@maastrichtuniversity.nl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Plomhause</LastName><ForeName>Lucie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France; Neurology and Movement Disorders Department, Lille University Medical Center, Lille, France. Electronic address: lucie.plomhause@chru-lille.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tard</LastName><ForeName>Celine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm, U1171, Troubles cognitifs dégénératifs et vasculaires, Université de Lille, Lille, France. Electronic address: celine.tard@chru-lille.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leentjens</LastName><ForeName>Albert F G</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Maastricht University Medical Center, Maastricht, The Netherlands. Electronic address: a.leentjens@maastrichtuniversity.nl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>08</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016000" MajorTopicYN="N">Cluster Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003072" MajorTopicYN="N">Cognition Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056344" MajorTopicYN="N">Executive Function</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008569" MajorTopicYN="N">Memory Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="Y">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Behavior</Keyword><Keyword MajorTopicYN="N">Cluster analysis</Keyword><Keyword MajorTopicYN="N">Cognition</Keyword><Keyword MajorTopicYN="N">Dementia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>08</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>08</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26350121</ArticleId><ArticleId IdType="pii">S1353-8020(15)00371-5</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2015.08.032</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li><li>Pays-Bas</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Dujardin, Kathy" sort="Dujardin, Kathy" uniqKey="Dujardin K" first="Kathy" last="Dujardin">Kathy Dujardin</name></region><name sortKey="Behal, Helene" sort="Behal, Helene" uniqKey="Behal H" first="Hélène" last="Behal">Hélène Behal</name><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><name sortKey="Duhamel, Alain" sort="Duhamel, Alain" uniqKey="Duhamel A" first="Alain" last="Duhamel">Alain Duhamel</name><name sortKey="Plomhause, Lucie" sort="Plomhause, Lucie" uniqKey="Plomhause L" first="Lucie" last="Plomhause">Lucie Plomhause</name><name sortKey="Tard, Celine" sort="Tard, Celine" uniqKey="Tard C" first="Celine" last="Tard">Celine Tard</name></country><country name="Pays-Bas"><noRegion><name sortKey="Moonen, Anja J H" sort="Moonen, Anja J H" uniqKey="Moonen A" first="Anja J H" last="Moonen">Anja J H. Moonen</name></noRegion><name sortKey="Duits, Annelien A" sort="Duits, Annelien A" uniqKey="Duits A" first="Annelien A" last="Duits">Annelien A. Duits</name><name sortKey="Leentjens, Albert F G" sort="Leentjens, Albert F G" uniqKey="Leentjens A" first="Albert F G" last="Leentjens">Albert F G. Leentjens</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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