ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:15885384

Treatment of motor dysfunction in Parkinson's disease: an overview

Identifieur interne : 002D37 ( Main/Exploration ); précédent : 002D36; suivant : 002D38

Treatment of motor dysfunction in Parkinson's disease: an overview

Auteurs : Stéphane Thobois [France] ; Florence Delamarre-Damier [France] ; Pascal Derkinderen [France]

Source :

Clinical neurology and neurosurgery [ 0303-8467 ] ; 2005.

RBID : Pascal:05-0254276

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Chirurgie, Traitement, Parkinson maladie, Lévodopa, Stimulant dopaminergique.
Wicri :
- topic : Chirurgie.

English descriptors

KwdEn :
- Animals, Antiparkinson Agents (therapeutic use), Deep Brain Stimulation, Dopamine agonist, Dyskinesias (etiology), Dyskinesias (therapy), Globus Pallidus (surgery), Humans, Levodopa, Nerve Growth Factors (therapeutic use), Nervous system diseases, Neurons (transplantation), Neuroprotective Agents (therapeutic use), Parkinson Disease (complications), Parkinson disease, Surgery, Thalamus (surgery), Treatment.
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Nerve Growth Factors, Neuroprotective Agents.
- complications : Parkinson Disease.
- etiology : Dyskinesias.
- surgery : Globus Pallidus, Thalamus.
- therapy : Dyskinesias.
- transplantation : Neurons.
- Animals, Deep Brain Stimulation, Humans.

Abstract

Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Treatment of motor dysfunction in Parkinson's disease: an overview

Treatment of motor dysfunction in Parkinson's disease: an overview

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
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