Treatment of motor dysfunction in Parkinson's disease: an overview
Identifieur interne : 000C89 ( PascalFrancis/Corpus ); précédent : 000C88; suivant : 000C90Treatment of motor dysfunction in Parkinson's disease: an overview
Auteurs : Stéphane Thobois ; Florence Delamarre-Damier ; Pascal DerkinderenSource :
- Clinical neurology and neurosurgery [ 0303-8467 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 05-0254276 INIST |
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ET : | Treatment of motor dysfunction in Parkinson's disease: an overview |
AU : | THOBOIS (Stéphane); DELAMARRE-DAMIER (Florence); DERKINDEREN (Pascal) |
AF : | Service de Neurologie, Hôpital Neurologique Pierre Wertheimer/Lyon/France (1 aut.); ITG, Consulting Group/Paris/France (2 aut.); Service de Neurologie et Centre d'investigations cliniques, CHU de Nantes, Hôpital Laennec/Nantes/France (3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Clinical neurology and neurosurgery; ISSN 0303-8467; Coden CNNSBV; Pays-Bas; Da. 2005; Vol. 107; No. 4; Pp. 269-281; Bibl. 171 ref. |
LA : | Anglais |
EA : | Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation. |
CC : | 002B25J |
FD : | Système nerveux pathologie; Chirurgie; Traitement; Parkinson maladie; Lévodopa; Stimulant dopaminergique |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie |
ED : | Nervous system diseases; Surgery; Treatment; Parkinson disease; Levodopa; Dopamine agonist |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Cirugía; Tratamiento; Parkinson enfermedad; Levodopa; Estimulante dopaminérgico |
LO : | INIST-4348.354000125421640010 |
ID : | 05-0254276 |
Links to Exploration step
Pascal:05-0254276Le document en format XML
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<front><div type="abstract" xml:lang="en">Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.</div>
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