La maladie de Parkinson en France (serveur d'exploration)

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Treatment of motor dysfunction in Parkinson's disease: an overview

Identifieur interne : 000C89 ( PascalFrancis/Corpus ); précédent : 000C88; suivant : 000C90

Treatment of motor dysfunction in Parkinson's disease: an overview

Auteurs : Stéphane Thobois ; Florence Delamarre-Damier ; Pascal Derkinderen

Source :

RBID : Pascal:05-0254276

Descripteurs français

English descriptors

Abstract

Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0303-8467
A02 01      @0 CNNSBV
A03   1    @0 Clin. neurol. neurosurg.
A05       @2 107
A06       @2 4
A08 01  1  ENG  @1 Treatment of motor dysfunction in Parkinson's disease: an overview
A11 01  1    @1 THOBOIS (Stéphane)
A11 02  1    @1 DELAMARRE-DAMIER (Florence)
A11 03  1    @1 DERKINDEREN (Pascal)
A14 01      @1 Service de Neurologie, Hôpital Neurologique Pierre Wertheimer @2 Lyon @3 FRA @Z 1 aut.
A14 02      @1 ITG, Consulting Group @2 Paris @3 FRA @Z 2 aut.
A14 03      @1 Service de Neurologie et Centre d'investigations cliniques, CHU de Nantes, Hôpital Laennec @2 Nantes @3 FRA @Z 3 aut.
A20       @1 269-281
A21       @1 2005
A23 01      @0 ENG
A43 01      @1 INIST @2 4348 @5 354000125421640010
A44       @0 0000 @1 © 2005 INIST-CNRS. All rights reserved.
A45       @0 171 ref.
A47 01  1    @0 05-0254276
A60       @1 P
A61       @0 A
A64 01  1    @0 Clinical neurology and neurosurgery
A66 01      @0 NLD
C01 01    ENG  @0 Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.
C02 01  X    @0 002B25J
C03 01  X  FRE  @0 Système nerveux pathologie @5 01
C03 01  X  ENG  @0 Nervous system diseases @5 01
C03 01  X  SPA  @0 Sistema nervioso patología @5 01
C03 02  X  FRE  @0 Chirurgie @5 02
C03 02  X  ENG  @0 Surgery @5 02
C03 02  X  SPA  @0 Cirugía @5 02
C03 03  X  FRE  @0 Traitement @5 03
C03 03  X  ENG  @0 Treatment @5 03
C03 03  X  SPA  @0 Tratamiento @5 03
C03 04  X  FRE  @0 Parkinson maladie @5 04
C03 04  X  ENG  @0 Parkinson disease @5 04
C03 04  X  SPA  @0 Parkinson enfermedad @5 04
C03 05  X  FRE  @0 Lévodopa @2 NK @2 FR @5 05
C03 05  X  ENG  @0 Levodopa @2 NK @2 FR @5 05
C03 05  X  SPA  @0 Levodopa @2 NK @2 FR @5 05
C03 06  X  FRE  @0 Stimulant dopaminergique @5 06
C03 06  X  ENG  @0 Dopamine agonist @5 06
C03 06  X  SPA  @0 Estimulante dopaminérgico @5 06
C07 01  X  FRE  @0 Encéphale pathologie @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Extrapyramidal syndrome @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Système nerveux central pathologie @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 178
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 05-0254276 INIST
ET : Treatment of motor dysfunction in Parkinson's disease: an overview
AU : THOBOIS (Stéphane); DELAMARRE-DAMIER (Florence); DERKINDEREN (Pascal)
AF : Service de Neurologie, Hôpital Neurologique Pierre Wertheimer/Lyon/France (1 aut.); ITG, Consulting Group/Paris/France (2 aut.); Service de Neurologie et Centre d'investigations cliniques, CHU de Nantes, Hôpital Laennec/Nantes/France (3 aut.)
DT : Publication en série; Niveau analytique
SO : Clinical neurology and neurosurgery; ISSN 0303-8467; Coden CNNSBV; Pays-Bas; Da. 2005; Vol. 107; No. 4; Pp. 269-281; Bibl. 171 ref.
LA : Anglais
EA : Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.
CC : 002B25J
FD : Système nerveux pathologie; Chirurgie; Traitement; Parkinson maladie; Lévodopa; Stimulant dopaminergique
FG : Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED : Nervous system diseases; Surgery; Treatment; Parkinson disease; Levodopa; Dopamine agonist
EG : Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD : Sistema nervioso patología; Cirugía; Tratamiento; Parkinson enfermedad; Levodopa; Estimulante dopaminérgico
LO : INIST-4348.354000125421640010
ID : 05-0254276

Links to Exploration step

Pascal:05-0254276

Le document en format XML

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