ParkinsonFranceV1, Main, Exploration, bibRecordById, pubmed:10349507

Pathophysiology of Parkinson's disease

Identifieur interne : 003D86 ( Main/Exploration ); précédent : 003D85; suivant : 003D87

Pathophysiology of Parkinson's disease

Auteurs : A. M. Bonnet [France] ; J. L. Houeto [France]

Source :

Biomedicine & Pharmacotherapy [ 0753-3322 ] ; 1999.

RBID : ISTEX:BE65A2895707726AA9471629442410A1C7019200

Descripteurs français

Pascal (Inist)
- Apoptose, Article synthèse, Facteur milieu, Homme, Maladie congénitale, Parkinson maladie, Pathogénie, Physiopathologie, Stress oxydatif, Voie dopaminergique.
Wicri :
- topic : Homme, Maladie congénitale.

English descriptors

KwdEn :
- Animals, Apoptosis, Apoptosis (physiology), Basal Ganglia (pathology), Brain Chemistry (physiology), Congenital disease, Dopaminergic pathway, Environmental Pollutants (toxicity), Environmental factor, Human, Humans, Oxidative Stress (physiology), Oxidative stress, Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Pathogenesis, Pathophysiology, Receptors, Dopamine (physiology), Review, pathophysiology.
MESH :
- chemical , physiology : Receptors, Dopamine.
- chemical , toxicity : Environmental Pollutants.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- pathology : Basal Ganglia, Parkinson Disease.
- physiology : Apoptosis, Brain Chemistry, Oxidative Stress.
- physiopathology : Parkinson Disease.
- Animals, Humans.

Abstract

Summary: Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.

Url:

https://api.istex.fr/document/BE65A2895707726AA9471629442410A1C7019200/fulltext/pdf

DOI: 10.1016/S0753-3322(99)80076-6

Affiliations:

Le document en format XML

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La maladie de Parkinson en France (serveur d'exploration)

Pathophysiology of Parkinson's disease

Pathophysiology of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.