Pathophysiology of Parkinson's disease
Identifieur interne : 003D86 ( Main/Exploration ); précédent : 003D85; suivant : 003D87Pathophysiology of Parkinson's disease
Auteurs : A. M. Bonnet [France] ; J. L. Houeto [France]Source :
- Biomedicine & Pharmacotherapy [ 0753-3322 ] ; 1999.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme, Maladie congénitale.
English descriptors
- KwdEn :
- Animals, Apoptosis, Apoptosis (physiology), Basal Ganglia (pathology), Brain Chemistry (physiology), Congenital disease, Dopaminergic pathway, Environmental Pollutants (toxicity), Environmental factor, Human, Humans, Oxidative Stress (physiology), Oxidative stress, Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Pathogenesis, Pathophysiology, Receptors, Dopamine (physiology), Review, pathophysiology.
- MESH :
- chemical , physiology : Receptors, Dopamine.
- chemical , toxicity : Environmental Pollutants.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- pathology : Basal Ganglia, Parkinson Disease.
- physiology : Apoptosis, Brain Chemistry, Oxidative Stress.
- physiopathology : Parkinson Disease.
- Animals, Humans.
Abstract
Summary: Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.
Url:
DOI: 10.1016/S0753-3322(99)80076-6
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Summary: Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.</div>
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