Pathophysiology of Parkinson's disease.
Identifieur interne : 001407 ( PubMed/Corpus ); précédent : 001406; suivant : 001408Pathophysiology of Parkinson's disease.
Auteurs : A M Bonnet ; J L HouetoSource :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 0753-3322 ] ; 1999.
English descriptors
- KwdEn :
- Animals, Apoptosis (physiology), Basal Ganglia (pathology), Brain Chemistry (physiology), Environmental Pollutants (toxicity), Humans, Oxidative Stress (physiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Receptors, Dopamine (physiology).
- MESH :
- chemical , physiology : Receptors, Dopamine.
- chemical , toxicity : Environmental Pollutants.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- pathology : Basal Ganglia, Parkinson Disease.
- physiology : Apoptosis, Brain Chemistry, Oxidative Stress.
- physiopathology : Parkinson Disease.
- Animals, Humans.
Abstract
Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.
DOI: 10.1016/S0753-3322(99)80076-6
PubMed: 10349507
Links to Exploration step
pubmed:10349507Le document en format XML
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The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10349507</PMID><DateCreated><Year>1999</Year><Month>07</Month><Day>21</Day></DateCreated><DateCompleted><Year>1999</Year><Month>07</Month><Day>21</Day></DateCompleted><DateRevised><Year>2005</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0753-3322</ISSN><JournalIssue CitedMedium="Print"><Volume>53</Volume><Issue>3</Issue><PubDate><Year>1999</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie</Title><ISOAbbreviation>Biomed. Pharmacother.</ISOAbbreviation></Journal><ArticleTitle>Pathophysiology of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>117-21</MedlinePgn></Pagination><Abstract><AbstractText>Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonnet</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Hôpital de la Pitié-Salpêtrière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houeto</LastName><ForeName>J L</ForeName><Initials>JL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Biomed Pharmacother</MedlineTA><NlmUniqueID>8213295</NlmUniqueID><ISSNLinking>0753-3322</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004785">Environmental Pollutants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011954">Receptors, Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001479" MajorTopicYN="N">Basal Ganglia</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001923" MajorTopicYN="N">Brain Chemistry</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004785" MajorTopicYN="N">Environmental Pollutants</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011954" MajorTopicYN="N">Receptors, Dopamine</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>48</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10349507</ArticleId><ArticleId IdType="pii">S0753-3322(99)80076-6</ArticleId><ArticleId IdType="doi">10.1016/S0753-3322(99)80076-6</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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