Pathophysiology of Parkinson's disease.
Identifieur interne : 001366 ( PubMed/Curation ); précédent : 001365; suivant : 001367Pathophysiology of Parkinson's disease.
Auteurs : A M Bonnet [France] ; J L HouetoSource :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [ 0753-3322 ] ; 1999.
English descriptors
- KwdEn :
- Animals, Apoptosis (physiology), Basal Ganglia (pathology), Brain Chemistry (physiology), Environmental Pollutants (toxicity), Humans, Oxidative Stress (physiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Receptors, Dopamine (physiology).
- MESH :
- chemical , physiology : Receptors, Dopamine.
- chemical , toxicity : Environmental Pollutants.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- pathology : Basal Ganglia, Parkinson Disease.
- physiology : Apoptosis, Brain Chemistry, Oxidative Stress.
- physiopathology : Parkinson Disease.
- Animals, Humans.
Abstract
Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.
DOI: 10.1016/S0753-3322(99)80076-6
PubMed: 10349507
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pubmed:10349507Le document en format XML
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<front><div type="abstract" xml:lang="en">Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.</div>
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<Abstract><AbstractText>Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research.</AbstractText>
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