ParkinsonFranceV1, Main, Exploration, bibRecordById, Pascal:05-0246795

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

Identifieur interne : 002D71 ( Main/Exploration ); précédent : 002D70; suivant : 002D72

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

Auteurs : Isabelle Biseul [France] ; Paul Sauleau [France] ; Claire Haegelen [France] ; Pascale Trebon [France] ; Dominique Drapier [France] ; Sylvie Raoul [France] ; Sophie Drapier [France] ; Francois Lallement [France] ; Isabelle Rivier [France] ; Youenn Lajat [France] ; Marc Verin [France]

Source :

Neuropsychologia [ 0028-3932 ] ; 2005.

RBID : Pascal:05-0246795

Descripteurs français

Pascal (Inist)
- Peur, Emotion émotivité, Cognition, Reconnaissance, Noyau sousthalamique, Parkinson maladie, Mimique, Face, Système limbique, Homme, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Cognition, Deep brain stimulation, Discrimination (Psychology) (physiology), Electric Stimulation Therapy (psychology), Emotion emotionality, Face, Facial Expression, Facial expression, Fear, Female, Human, Humans, Limbic system, Male, Middle Aged, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Recognition, Recognition (Psychology) (physiology), Reference Values, Statistics, Nonparametric, Subthalamic Nucleus (physiology), Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (surgery), Subthalamic nucleus.
MESH :
- physiology : Discrimination (Psychology), Recognition (Psychology), Subthalamic Nucleus.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- psychology : Electric Stimulation Therapy, Parkinson Disease.
- surgery : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Facial Expression, Fear, Female, Humans, Male, Middle Aged, Reference Values, Statistics, Nonparametric.

Abstract

Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.

Affiliations:

Le document en format XML

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<seriesStmt><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition</term>
<term>Deep brain stimulation</term>
<term>Discrimination (Psychology) (physiology)</term>
<term>Electric Stimulation Therapy (psychology)</term>
<term>Emotion emotionality</term>
<term>Face</term>
<term>Facial Expression</term>
<term>Facial expression</term>
<term>Fear</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Limbic system</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Recognition</term>
<term>Recognition (Psychology) (physiology)</term>
<term>Reference Values</term>
<term>Statistics, Nonparametric</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Subthalamic Nucleus (surgery)</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term>
<term>Recognition (Psychology)</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Electric Stimulation Therapy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Facial Expression</term>
<term>Fear</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Peur</term>
<term>Emotion émotivité</term>
<term>Cognition</term>
<term>Reconnaissance</term>
<term>Noyau sousthalamique</term>
<term>Parkinson maladie</term>
<term>Mimique</term>
<term>Face</term>
<term>Système limbique</term>
<term>Homme</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Pays de la Loire</li>
<li>Région Bretagne</li>
</region>
<settlement><li>Nantes</li>
<li>Rennes</li>
</settlement>
</list>
<tree><country name="France"><region name="Région Bretagne"><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
</region>
<name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
<name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
<name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
<name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="Francois" last="Lallement">Francois Lallement</name>
<name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
<name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
<name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
<name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
<name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

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	La maladie de Parkinson en France (serveur d'exploration)
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