Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease
Identifieur interne : 002D71 ( Main/Curation ); précédent : 002D70; suivant : 002D72Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease
Auteurs : Isabelle Biseul [France] ; Paul Sauleau [France] ; Claire Haegelen [France] ; Pascale Trebon [France] ; Dominique Drapier [France] ; Sylvie Raoul [France] ; Sophie Drapier [France] ; Francois Lallement [France] ; Isabelle Rivier [France] ; Youenn Lajat [France] ; Marc Verin [France]Source :
- Neuropsychologia [ 0028-3932 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Cognition, Deep brain stimulation, Discrimination (Psychology) (physiology), Electric Stimulation Therapy (psychology), Emotion emotionality, Face, Facial Expression, Facial expression, Fear, Female, Human, Humans, Limbic system, Male, Middle Aged, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Recognition, Recognition (Psychology) (physiology), Reference Values, Statistics, Nonparametric, Subthalamic Nucleus (physiology), Subthalamic Nucleus (physiopathology), Subthalamic Nucleus (surgery), Subthalamic nucleus.
- MESH :
- physiology : Discrimination (Psychology), Recognition (Psychology), Subthalamic Nucleus.
- physiopathology : Parkinson Disease, Subthalamic Nucleus.
- psychology : Electric Stimulation Therapy, Parkinson Disease.
- surgery : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Facial Expression, Fear, Female, Humans, Male, Middle Aged, Reference Values, Statistics, Nonparametric.
Abstract
Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000C90
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000744
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000B25
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003148
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000F80
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000F40
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000F40
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000507
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000507
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000507
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002F39
Links to Exploration step
Pascal:05-0246795Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease</title>
<author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="Francois" last="Lallement">Francois Lallement</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0246795</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0246795 INIST</idno>
<idno type="RBID">Pascal:05-0246795</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C90</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000744</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000B25</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B25</idno>
<idno type="wicri:doubleKey">0028-3932:2005:Biseul I:fear:recognition:is</idno>
<idno type="wicri:Area/Main/Merge">003148</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:15769491</idno>
<idno type="wicri:Area/PubMed/Corpus">000F80</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F80</idno>
<idno type="wicri:Area/PubMed/Curation">000F40</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F40</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000F40</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F40</idno>
<idno type="wicri:Area/Ncbi/Merge">000507</idno>
<idno type="wicri:Area/Ncbi/Curation">000507</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000507</idno>
<idno type="wicri:doubleKey">0028-3932:2005:Biseul I:fear:recognition:is</idno>
<idno type="wicri:Area/Main/Merge">002F39</idno>
<idno type="wicri:Area/Main/Curation">002D71</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease</title>
<author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="Francois" last="Lallement">Francois Lallement</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition</term>
<term>Deep brain stimulation</term>
<term>Discrimination (Psychology) (physiology)</term>
<term>Electric Stimulation Therapy (psychology)</term>
<term>Emotion emotionality</term>
<term>Face</term>
<term>Facial Expression</term>
<term>Facial expression</term>
<term>Fear</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Limbic system</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Recognition</term>
<term>Recognition (Psychology) (physiology)</term>
<term>Reference Values</term>
<term>Statistics, Nonparametric</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Subthalamic Nucleus (surgery)</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term>
<term>Recognition (Psychology)</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Electric Stimulation Therapy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Facial Expression</term>
<term>Fear</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
<term>Statistics, Nonparametric</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Peur</term>
<term>Emotion émotivité</term>
<term>Cognition</term>
<term>Reconnaissance</term>
<term>Noyau sousthalamique</term>
<term>Parkinson maladie</term>
<term>Mimique</term>
<term>Face</term>
<term>Système limbique</term>
<term>Homme</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.</div>
</front>
</TEI>
<double idat="0028-3932:2005:Biseul I:fear:recognition:is"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease</title>
<author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="Francois" last="Lallement">Francois Lallement</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">05-0246795</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0246795 INIST</idno>
<idno type="RBID">Pascal:05-0246795</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000C90</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000744</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000B25</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000B25</idno>
<idno type="wicri:doubleKey">0028-3932:2005:Biseul I:fear:recognition:is</idno>
<idno type="wicri:Area/Main/Merge">003148</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease</title>
<author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="Francois" last="Lallement">Francois Lallement</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes</s1>
<s2>44000 Nantes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux</s1>
<s2>35033 Rennes</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neuropsychologia</title>
<title level="j" type="abbreviated">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term>
<term>Deep brain stimulation</term>
<term>Emotion emotionality</term>
<term>Face</term>
<term>Facial expression</term>
<term>Fear</term>
<term>Human</term>
<term>Limbic system</term>
<term>Parkinson disease</term>
<term>Recognition</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Peur</term>
<term>Emotion émotivité</term>
<term>Cognition</term>
<term>Reconnaissance</term>
<term>Noyau sousthalamique</term>
<term>Parkinson maladie</term>
<term>Mimique</term>
<term>Face</term>
<term>Système limbique</term>
<term>Homme</term>
<term>Stimulation cérébrale profonde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease.</title>
<author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux, 35033 Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux, 35033 Rennes</wicri:regionArea>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
</author>
<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
</author>
<author><name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
</author>
<author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
</author>
<author><name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
</author>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
</author>
<author><name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="François" last="Lallement">François Lallement</name>
</author>
<author><name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
</author>
<author><name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:15769491</idno>
<idno type="pmid">15769491</idno>
<idno type="doi">10.1016/j.neuropsychologia.2004.10.006</idno>
<idno type="wicri:Area/PubMed/Corpus">000F80</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F80</idno>
<idno type="wicri:Area/PubMed/Curation">000F40</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F40</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000F40</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F40</idno>
<idno type="wicri:Area/Ncbi/Merge">000507</idno>
<idno type="wicri:Area/Ncbi/Curation">000507</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000507</idno>
<idno type="wicri:doubleKey">0028-3932:2005:Biseul I:fear:recognition:is</idno>
<idno type="wicri:Area/Main/Merge">002F39</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease.</title>
<author><name sortKey="Biseul, Isabelle" sort="Biseul, Isabelle" uniqKey="Biseul I" first="Isabelle" last="Biseul">Isabelle Biseul</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux, 35033 Rennes, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux, 35033 Rennes</wicri:regionArea>
<placeName><region type="region" nuts="2">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
</author>
<author><name sortKey="Haegelen, Claire" sort="Haegelen, Claire" uniqKey="Haegelen C" first="Claire" last="Haegelen">Claire Haegelen</name>
</author>
<author><name sortKey="Trebon, Pascale" sort="Trebon, Pascale" uniqKey="Trebon P" first="Pascale" last="Trebon">Pascale Trebon</name>
</author>
<author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name>
</author>
<author><name sortKey="Raoul, Sylvie" sort="Raoul, Sylvie" uniqKey="Raoul S" first="Sylvie" last="Raoul">Sylvie Raoul</name>
</author>
<author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name>
</author>
<author><name sortKey="Lallement, Francois" sort="Lallement, Francois" uniqKey="Lallement F" first="François" last="Lallement">François Lallement</name>
</author>
<author><name sortKey="Rivier, Isabelle" sort="Rivier, Isabelle" uniqKey="Rivier I" first="Isabelle" last="Rivier">Isabelle Rivier</name>
</author>
<author><name sortKey="Lajat, Youenn" sort="Lajat, Youenn" uniqKey="Lajat Y" first="Youenn" last="Lajat">Youenn Lajat</name>
</author>
<author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Verin">Marc Verin</name>
</author>
</analytic>
<series><title level="j">Neuropsychologia</title>
<idno type="ISSN">0028-3932</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Discrimination (Psychology) (physiology)</term>
<term>Electric Stimulation Therapy (psychology)</term>
<term>Facial Expression</term>
<term>Fear</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Recognition (Psychology) (physiology)</term>
<term>Reference Values</term>
<term>Statistics, Nonparametric</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic Nucleus (physiopathology)</term>
<term>Subthalamic Nucleus (surgery)</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Discrimination (Psychology)</term>
<term>Recognition (Psychology)</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Electric Stimulation Therapy</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Facial Expression</term>
<term>Fear</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reference Values</term>
<term>Statistics, Nonparametric</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D71 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002D71 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:05-0246795 |texte= Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |