ParkinsonFranceV1, PascalFrancis, Corpus, bibRecord, 000C90

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

Identifieur interne : 000C90 ( PascalFrancis/Corpus ); précédent : 000C89; suivant : 000C91

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

Auteurs : Isabelle Biseul ; Paul Sauleau ; Claire Haegelen ; Pascale Trebon ; Dominique Drapier ; Sylvie Raoul ; Sophie Drapier ; Francois Lallement ; Isabelle Rivier ; Youenn Lajat ; Marc Verin

Source :

Neuropsychologia [ 0028-3932 ] ; 2005.

RBID : Pascal:05-0246795

Descripteurs français

Pascal (Inist)
- Peur, Emotion émotivité, Cognition, Reconnaissance, Noyau sousthalamique, Parkinson maladie, Mimique, Face, Système limbique, Homme, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Cognition, Deep brain stimulation, Emotion emotionality, Face, Facial expression, Fear, Human, Limbic system, Parkinson disease, Recognition, Subthalamic nucleus.

Abstract

Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.
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C03	`01`	`X`	`ENG`	`@0 Fear @5 01`
C03	`01`	`X`	`SPA`	`@0 Miedo @5 01`
C03	`02`	`X`	`FRE`	`@0 Emotion émotivité @5 02`
C03	`02`	`X`	`ENG`	`@0 Emotion emotionality @5 02`
C03	`02`	`X`	`SPA`	`@0 Emoción emotividad @5 02`
C03	`03`	`X`	`FRE`	`@0 Cognition @5 03`
C03	`03`	`X`	`ENG`	`@0 Cognition @5 03`
C03	`03`	`X`	`SPA`	`@0 Cognición @5 03`
C03	`04`	`X`	`FRE`	`@0 Reconnaissance @5 04`
C03	`04`	`X`	`ENG`	`@0 Recognition @5 04`
C03	`04`	`X`	`SPA`	`@0 Reconocimiento @5 04`
C03	`05`	`X`	`FRE`	`@0 Noyau sousthalamique @5 05`
C03	`05`	`X`	`ENG`	`@0 Subthalamic nucleus @5 05`
C03	`05`	`X`	`SPA`	`@0 Núcleo subtalámico @5 05`
C03	`06`	`X`	`FRE`	`@0 Parkinson maladie @5 06`
C03	`06`	`X`	`ENG`	`@0 Parkinson disease @5 06`
C03	`06`	`X`	`SPA`	`@0 Parkinson enfermedad @5 06`
C03	`07`	`X`	`FRE`	`@0 Mimique @5 07`
C03	`07`	`X`	`ENG`	`@0 Facial expression @5 07`
C03	`07`	`X`	`SPA`	`@0 Mímica @5 07`
C03	`08`	`X`	`FRE`	`@0 Face @5 08`
C03	`08`	`X`	`ENG`	`@0 Face @5 08`
C03	`08`	`X`	`SPA`	`@0 Cara @5 08`
C03	`09`	`X`	`FRE`	`@0 Système limbique @5 09`
C03	`09`	`X`	`ENG`	`@0 Limbic system @5 09`
C03	`09`	`X`	`SPA`	`@0 Sistema límbico @5 09`
C03	`10`	`X`	`FRE`	`@0 Homme @5 18`
C03	`10`	`X`	`ENG`	`@0 Human @5 18`
C03	`10`	`X`	`SPA`	`@0 Hombre @5 18`
C03	`11`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`11`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Affect affectivité @5 37`
C07	`01`	`X`	`ENG`	`@0 Affect affectivity @5 37`
C07	`01`	`X`	`SPA`	`@0 Afecto afectividad @5 37`
C07	`02`	`X`	`FRE`	`@0 Encéphale pathologie @5 38`
C07	`02`	`X`	`ENG`	`@0 Cerebral disorder @5 38`
C07	`02`	`X`	`SPA`	`@0 Encéfalo patología @5 38`
C07	`03`	`X`	`FRE`	`@0 Système nerveux central @5 39`
C07	`03`	`X`	`ENG`	`@0 Central nervous system @5 39`
C07	`03`	`X`	`SPA`	`@0 Sistema nervioso central @5 39`
C07	`04`	`X`	`FRE`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 40`
C07	`04`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 40`
C07	`05`	`X`	`FRE`	`@0 Maladie dégénérative @5 41`
C07	`05`	`X`	`ENG`	`@0 Degenerative disease @5 41`
C07	`05`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 41`
C07	`06`	`X`	`FRE`	`@0 Système nerveux central pathologie @5 42`
C07	`06`	`X`	`ENG`	`@0 Central nervous system disease @5 42`
C07	`06`	`X`	`SPA`	`@0 Sistema nervosio central patología @5 42`
C07	`07`	`X`	`FRE`	`@0 Système nerveux pathologie @5 43`
C07	`07`	`X`	`ENG`	`@0 Nervous system diseases @5 43`
C07	`07`	`X`	`SPA`	`@0 Sistema nervioso patología @5 43`
N21				`@1 171`

Format Inist (serveur)

NO :	PASCAL 05-0246795 INIST
ET :	Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease
AU :	BISEUL (Isabelle); SAULEAU (Paul); HAEGELEN (Claire); TREBON (Pascale); DRAPIER (Dominique); RAOUL (Sylvie); DRAPIER (Sophie); LALLEMENT (Francois); RIVIER (Isabelle); LAJAT (Youenn); VERIN (Marc)
AF :	Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux/35033 Rennes/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut., 9 aut., 11 aut.); Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes/44000 Nantes/France (6 aut., 8 aut., 10 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2005; Vol. 43; No. 7; Pp. 1054-1059; Bibl. 1 p.1/4
LA :	Anglais
EA :	Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.
CC :	002A26C04
FD :	Peur; Emotion émotivité; Cognition; Reconnaissance; Noyau sousthalamique; Parkinson maladie; Mimique; Face; Système limbique; Homme; Stimulation cérébrale profonde
FG :	Affect affectivité; Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie
ED :	Fear; Emotion emotionality; Cognition; Recognition; Subthalamic nucleus; Parkinson disease; Facial expression; Face; Limbic system; Human; Deep brain stimulation
EG :	Affect affectivity; Cerebral disorder; Central nervous system; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases
SD :	Miedo; Emoción emotividad; Cognición; Reconocimiento; Núcleo subtalámico; Parkinson enfermedad; Mímica; Cara; Sistema límbico; Hombre
LO :	INIST-11143.354000125422140050
ID :	05-0246795

Links to Exploration step

Pascal:05-0246795

Le document en format XML

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<front><div type="abstract" xml:lang="en">Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.</div>
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<ET>Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease</ET>
<AU>BISEUL (Isabelle); SAULEAU (Paul); HAEGELEN (Claire); TREBON (Pascale); DRAPIER (Dominique); RAOUL (Sylvie); DRAPIER (Sophie); LALLEMENT (Francois); RIVIER (Isabelle); LAJAT (Youenn); VERIN (Marc)</AU>
<AF>Clinique Neurologique, Hôpital Pontchaillou, CHU de Rennes, Rue Henri Le Guilloux/35033 Rennes/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 7 aut., 9 aut., 11 aut.); Service de Neurochirurgie, Hôpital Laennec, CHU de Nantes/44000 Nantes/France (6 aut., 8 aut., 10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2005; Vol. 43; No. 7; Pp. 1054-1059; Bibl. 1 p.1/4</SO>
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<EA>Behavioural disturbances such as disorders of mood, apathy or indifference are often observed in Parkinson's disease (PD) patients with chronic high frequency deep brain stimulation of subthalamic nucleus (STN DBS). Neuropsychological modifications causing these adverse events induced by STN DBS remain unknown, even if limbic disturbances are hypothesised. The limbic system supports neural circuits processing emotional information. The aim of this work is to evaluate changes of emotional recognition in PD patients induced by STN DBS. Thirty PD patients were assessed using a computerised paradigm of recognition of emotional facial expressions [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press], 15 before STN DBS and 15 after. The two patients groups were compared to a group of 15 healthy control subjects. One series of 55 pictures of emotional facial expressions was presented to each patient. Patients had to classify the pictures according to seven basic emotions (happiness, sadness, fear, surprise, disgust, anger and no emotion). The intact ability to percept faces was firstly assured using the Benton Recognition Test. Recognition of fear expressions was significantly and selectively reduced in the post-operative group in comparison to both pre-operative and control groups. Our results demonstrate for the first time a selective reduction of recognition of facial expressions of fear by STN DBS. This impairment could be the first neuropsychological marker of a more general limbic dysfunction, thought to be responsible for the behavioural disorders reported after STN DBS.</EA>
<CC>002A26C04</CC>
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<FG>Affect affectivité; Encéphale pathologie; Système nerveux central; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie</FG>
<ED>Fear; Emotion emotionality; Cognition; Recognition; Subthalamic nucleus; Parkinson disease; Facial expression; Face; Limbic system; Human; Deep brain stimulation</ED>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson's disease

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