ParkinsonFranceV1, Main, Exploration, bibRecordById, ISTEX:CC2812BB34683B8A7D4AF1FC4467460CEA86A77A

Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography

Identifieur interne : 004A06 ( Main/Exploration ); précédent : 004A05; suivant : 004A07

Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography

Auteurs : Stéphane Lehéricy [France] ; Jean-Philippe Brandel [France] ; Etienne C. Hirsch [France] ; Philippe Anglade [France] ; Joao Villares [France] ; Daniel Scherman [France] ; Charles Duyckaerts [France] ; France Javoy-Agid [France] ; Yves Agid [France]

Source :

Brain Research [ 0006-8993 ] ; 1994.

RBID : ISTEX:CC2812BB34683B8A7D4AF1FC4467460CEA86A77A

Descripteurs français

Pascal (Inist)
- Autoradiographie, Corps strié, Dopamine, Démence Alzheimer, Etude comparative, Exploration, Homme, Neurone dopaminergique, Parkinson maladie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (metabolism), Alzheimer disease, Autoradiography, Binding Sites, Biogenic Monoamines (metabolism), Caudate nucleus, Comparative study, Corpus Striatum (metabolism), Corpus striatum, Dopamine, Dopaminergic neuron, Exploration, Female, Human, Human brain, Humans, Male, Matrix, Middle Aged, Monoamine, Parkinson Disease (metabolism), Parkinson disease, Putamen, Reference Values, Striosome, Tetrabenazine (analogs & derivatives), Tetrabenazine (metabolism), Tritium, Ventral striatum.
MESH :
- chemical , analogs & derivatives : Tetrabenazine.
- chemical , metabolism : Biogenic Monoamines, Tetrabenazine.
- metabolism : Alzheimer Disease, Corpus Striatum, Parkinson Disease.
- Aged, Aged, 80 and over, Autoradiography, Binding Sites, Female, Humans, Male, Middle Aged, Reference Values, Tritium.

Abstract

The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (3H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of 3H-TBZOH was specific and saturable (Kd 5.3 nM). In control striatum, the pattern of distribution of 3H-TBZOH binding was heterogeneous, with higher binding levels in the ‘matrix’ than in the ‘striosome’ compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of 3H-TBZOH binding was reduced. A severe decrease in 3H-TBZOH binding was observed in all parts of the striatum (caudate nucleus: −80%, putamen: −86%, ventral striatum: −94%) in PD brains. The data corroborate the deficiency in striatal dopaminergic transmission and suggest that in PD brains dopaminergic terminals have disappeared and/or no longer contain synaptic vesicles. In Alzheimer's disease (AD), 3H-TBZOH binding was significantly reduced by 57% in the ventral striatum and not in the caudate nucleus and putamen. The specific decrease of monoaminergic transporter levels in the ventral striatum confirm that this nucleus is a target area in AD.

Url:

https://api.istex.fr/document/CC2812BB34683B8A7D4AF1FC4467460CEA86A77A/fulltext/pdf

DOI: 10.1016/0006-8993(94)90856-7

Affiliations:

Le document en format XML

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<term>Autoradiography</term>
<term>Binding Sites</term>
<term>Biogenic Monoamines (metabolism)</term>
<term>Caudate nucleus</term>
<term>Comparative study</term>
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<front><div type="abstract" xml:lang="en">The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (3H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of 3H-TBZOH was specific and saturable (Kd 5.3 nM). In control striatum, the pattern of distribution of 3H-TBZOH binding was heterogeneous, with higher binding levels in the ‘matrix’ than in the ‘striosome’ compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of 3H-TBZOH binding was reduced. A severe decrease in 3H-TBZOH binding was observed in all parts of the striatum (caudate nucleus: −80%, putamen: −86%, ventral striatum: −94%) in PD brains. The data corroborate the deficiency in striatal dopaminergic transmission and suggest that in PD brains dopaminergic terminals have disappeared and/or no longer contain synaptic vesicles. In Alzheimer's disease (AD), 3H-TBZOH binding was significantly reduced by 57% in the ventral striatum and not in the caudate nucleus and putamen. The specific decrease of monoaminergic transporter levels in the ventral striatum confirm that this nucleus is a target area in AD.</div>
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La maladie de Parkinson en France (serveur d'exploration)

Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography

Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.