Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography
Identifieur interne : 001936 ( PascalFrancis/Corpus ); précédent : 001935; suivant : 001937Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography
Auteurs : S. Lehericy ; J.-P. Brandel ; E. C. Hirsch ; P. Anglade ; J. Villares ; D. Scherman ; C. Duyckaerts ; F. Javoy-Agid ; Y. AgidSource :
- Brain research [ 0006-8993 ] ; 1994.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (3H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of 3H-TBZOH was specific and saturable (Kd 5.3 nM). In control striatum, the pattern of distribution of 3H-TBZOH binding was heterogeneous, with higher binding levels in the «matrix» than in the «striosome» compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of 3H-TBZOH binding was reduced
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 94-0677079 INIST |
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ET : | Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography |
AU : | LEHERICY (S.); BRANDEL (J.-P.); HIRSCH (E. C.); ANGLADE (P.); VILLARES (J.); SCHERMAN (D.); DUYCKAERTS (C.); JAVOY-AGID (F.); AGID (Y.) |
AF : | INSERM, U 289 lab. médecine exp./Paris/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut., 9 aut.); Rhône-Poulenc Rorer/94403 Vitry sur Seine/France (6 aut.); Hôp. Salpêtrière, lab. neuropathologie/Paris/France (7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1994; Vol. 659; No. 1-2; Pp. 1-9; Bibl. 45 ref. |
LA : | Anglais |
EA : | The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (3H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of 3H-TBZOH was specific and saturable (Kd 5.3 nM). In control striatum, the pattern of distribution of 3H-TBZOH binding was heterogeneous, with higher binding levels in the «matrix» than in the «striosome» compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of 3H-TBZOH binding was reduced |
CC : | 002B17G |
FD : | Exploration; Parkinson maladie; Démence Alzheimer; Corps strié; Dopamine; Neurone dopaminergique; Etude comparative; Autoradiographie; Homme |
FG : | Maladie dégénérative; Système nerveux pathologie; Noyau gris central; Encéphale; Système nerveux central; Neurotransmetteur; Catécholamine |
ED : | Exploration; Parkinson disease; Alzheimer disease; Corpus striatum; Dopamine; Dopaminergic neuron; Comparative study; Autoradiography; Human |
EG : | Degenerative disease; Nervous system diseases; Basal ganglion; Brain (vertebrata); Central nervous system; Neurotransmitter; Catecholamine |
GD : | Vergleich; Autoradiographie |
SD : | Exploración; Parkinson enfermedad; Demencia Alzheimer; Cuerpo estriado; Dopamina; Neurona dopaminérgica; Estudio comparativo; Autorradiografía; Hombre |
LO : | INIST-12895.354000041405480010 |
ID : | 94-0677079 |
Links to Exploration step
Pascal:94-0677079Le document en format XML
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<front><div type="abstract" xml:lang="en">The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (<sup>3</sup>
H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of <sup>3</sup>
H-TBZOH was specific and saturable (K<sub>d</sub>
5.3 nM). In control striatum, the pattern of distribution of <sup>3</sup>
H-TBZOH binding was heterogeneous, with higher binding levels in the «matrix» than in the «striosome» compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of <sup>3</sup>
H-TBZOH binding was reduced</div>
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H-TBZOH was specific and saturable (K<sub>d</sub>
5.3 nM). In control striatum, the pattern of distribution of <sup>3</sup>
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<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Dopaminergic neuron</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Neurona dopaminérgica</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="GER"><s0>Vergleich</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Autoradiographie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Autoradiography</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="GER"><s0>Autoradiographie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Autorradiografía</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0>
<s5>41</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Human</s0>
<s5>41</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0>
<s5>41</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Noyau gris central</s0>
<s5>26</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Basal ganglion</s0>
<s5>26</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Núcleo basal</s0>
<s5>26</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>27</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>27</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>27</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>28</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>28</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>28</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Neurotransmetteur</s0>
<s5>29</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Neurotransmitter</s0>
<s5>29</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Neurotransmisor</s0>
<s5>29</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>30</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>30</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>30</s5>
</fC07>
<fN21><s1>338</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 94-0677079 INIST</NO>
<ET>Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography</ET>
<AU>LEHERICY (S.); BRANDEL (J.-P.); HIRSCH (E. C.); ANGLADE (P.); VILLARES (J.); SCHERMAN (D.); DUYCKAERTS (C.); JAVOY-AGID (F.); AGID (Y.)</AU>
<AF>INSERM, U 289 lab. médecine exp./Paris/France (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 8 aut., 9 aut.); Rhône-Poulenc Rorer/94403 Vitry sur Seine/France (6 aut.); Hôp. Salpêtrière, lab. neuropathologie/Paris/France (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Brain research; ISSN 0006-8993; Coden BRREAP; Pays-Bas; Da. 1994; Vol. 659; No. 1-2; Pp. 1-9; Bibl. 45 ref.</SO>
<LA>Anglais</LA>
<EA>The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (<sup>3</sup>
H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of <sup>3</sup>
H-TBZOH was specific and saturable (K<sub>d</sub>
5.3 nM). In control striatum, the pattern of distribution of <sup>3</sup>
H-TBZOH binding was heterogeneous, with higher binding levels in the «matrix» than in the «striosome» compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of <sup>3</sup>
H-TBZOH binding was reduced</EA>
<CC>002B17G</CC>
<FD>Exploration; Parkinson maladie; Démence Alzheimer; Corps strié; Dopamine; Neurone dopaminergique; Etude comparative; Autoradiographie; Homme</FD>
<FG>Maladie dégénérative; Système nerveux pathologie; Noyau gris central; Encéphale; Système nerveux central; Neurotransmetteur; Catécholamine</FG>
<ED>Exploration; Parkinson disease; Alzheimer disease; Corpus striatum; Dopamine; Dopaminergic neuron; Comparative study; Autoradiography; Human</ED>
<EG>Degenerative disease; Nervous system diseases; Basal ganglion; Brain (vertebrata); Central nervous system; Neurotransmitter; Catecholamine</EG>
<GD>Vergleich; Autoradiographie</GD>
<SD>Exploración; Parkinson enfermedad; Demencia Alzheimer; Cuerpo estriado; Dopamina; Neurona dopaminérgica; Estudio comparativo; Autorradiografía; Hombre</SD>
<LO>INIST-12895.354000041405480010</LO>
<ID>94-0677079</ID>
</server>
</inist>
</record>
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