Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography
Identifieur interne : 005438 ( Main/Merge ); précédent : 005437; suivant : 005439Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography
Auteurs : S. Lehericy [France] ; J.-P. Brandel [France] ; E. C. Hirsch [France] ; P. Anglade [France] ; J. Villares [France] ; D. Scherman [France] ; C. Duyckaerts [France] ; F. Javoy-Agid [France] ; Yves Agid [France]Source :
- Brain research [ 0006-8993 ] ; 1994.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (3H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of 3H-TBZOH was specific and saturable (Kd 5.3 nM). In control striatum, the pattern of distribution of 3H-TBZOH binding was heterogeneous, with higher binding levels in the «matrix» than in the «striosome» compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of 3H-TBZOH binding was reduced
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001936
- to stream PascalFrancis, to step Curation: 001716
- to stream PascalFrancis, to step Checkpoint: 001794
Links to Exploration step
Pascal:94-0677079Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography</title><author><name sortKey="Lehericy, S" sort="Lehericy, S" uniqKey="Lehericy S" first="S." last="Lehericy">S. Lehericy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brandel, J P" sort="Brandel, J P" uniqKey="Brandel J" first="J.-P." last="Brandel">J.-P. Brandel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Anglade, P" sort="Anglade, P" uniqKey="Anglade P" first="P." last="Anglade">P. Anglade</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Villares, J" sort="Villares, J" uniqKey="Villares J" first="J." last="Villares">J. Villares</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Scherman, D" sort="Scherman, D" uniqKey="Scherman D" first="D." last="Scherman">D. Scherman</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Rhône-Poulenc Rorer</s1><s2>94403 Vitry sur Seine</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry sur Seine</settlement></placeName></affiliation></author><author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hôp. Salpêtrière, lab. neuropathologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">94-0677079</idno><date when="1994">1994</date><idno type="stanalyst">PASCAL 94-0677079 INIST</idno><idno type="RBID">Pascal:94-0677079</idno><idno type="wicri:Area/PascalFrancis/Corpus">001936</idno><idno type="wicri:Area/PascalFrancis/Curation">001716</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001794</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001794</idno><idno type="wicri:doubleKey">0006-8993:1994:Lehericy S:monoamine:vesicular:uptake</idno><idno type="wicri:Area/Main/Merge">005438</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography</title><author><name sortKey="Lehericy, S" sort="Lehericy, S" uniqKey="Lehericy S" first="S." last="Lehericy">S. Lehericy</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Brandel, J P" sort="Brandel, J P" uniqKey="Brandel J" first="J.-P." last="Brandel">J.-P. Brandel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Anglade, P" sort="Anglade, P" uniqKey="Anglade P" first="P." last="Anglade">P. Anglade</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Villares, J" sort="Villares, J" uniqKey="Villares J" first="J." last="Villares">J. Villares</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Scherman, D" sort="Scherman, D" uniqKey="Scherman D" first="D." last="Scherman">D. Scherman</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Rhône-Poulenc Rorer</s1><s2>94403 Vitry sur Seine</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Vitry sur Seine</settlement></placeName></affiliation></author><author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hôp. Salpêtrière, lab. neuropathologie</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM, U 289 lab. médecine exp.</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName></affiliation></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="1994">1994</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Autoradiography</term><term>Comparative study</term><term>Corpus striatum</term><term>Dopamine</term><term>Dopaminergic neuron</term><term>Exploration</term><term>Human</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Exploration</term><term>Parkinson maladie</term><term>Démence Alzheimer</term><term>Corps strié</term><term>Dopamine</term><term>Neurone dopaminergique</term><term>Etude comparative</term><term>Autoradiographie</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The monoaminergic innervation of the caudate nucleus, putamen and ventral striatum was investigated post mortem, in patients with Parkinson's and Alzheimer's disease as compared to control subjects, by autoradiographic detection of tritiated dihydrotetrabenazine (<sup>3</sup>H-TBZOH), a specific high affinity ligand of the vesicular monoamine transporter. The binding of <sup>3</sup>H-TBZOH was specific and saturable (K<sub>d</sub> 5.3 nM). In control striatum, the pattern of distribution of <sup>3</sup>H-TBZOH binding was heterogeneous, with higher binding levels in the «matrix» than in the «striosome» compartment. Changes in ligand binding levels were observed in the pathological brains compared to controls. In Parkinson's disease (PD), characterized by a severe damage of mesostriatal dopaminergic neurons, the density of <sup>3</sup>H-TBZOH binding was reduced</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li><li>Vitry sur Seine</li></settlement><orgName><li>Hôpital de la Salpêtrière</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Lehericy, S" sort="Lehericy, S" uniqKey="Lehericy S" first="S." last="Lehericy">S. Lehericy</name></region><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name><name sortKey="Anglade, P" sort="Anglade, P" uniqKey="Anglade P" first="P." last="Anglade">P. Anglade</name><name sortKey="Brandel, J P" sort="Brandel, J P" uniqKey="Brandel J" first="J.-P." last="Brandel">J.-P. Brandel</name><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name><name sortKey="Javoy Agid, F" sort="Javoy Agid, F" uniqKey="Javoy Agid F" first="F." last="Javoy-Agid">F. Javoy-Agid</name><name sortKey="Scherman, D" sort="Scherman, D" uniqKey="Scherman D" first="D." last="Scherman">D. Scherman</name><name sortKey="Villares, J" sort="Villares, J" uniqKey="Villares J" first="J." last="Villares">J. Villares</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005438 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 005438 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Merge
|type= RBID
|clé= Pascal:94-0677079
|texte= Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography
}}
| This area was generated with Dilib version V0.6.29. |  |