Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk.
Identifieur interne : 000D75 ( Main/Exploration ); précédent : 000D74; suivant : 000D76Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk.
Auteurs : Valentina Moskvina ; Denise Harold ; Giancarlo Russo ; Alexey Vedernikov ; Manu Sharma ; Mohamed Saad ; Peter Holmans ; Jose M. Bras ; Francesco Bettella ; Margaux F. Keller ; Nayia Nicolaou ; Javier Sim N-Sánchez ; J Raphael Gibbs ; Claudia Schulte ; Alexandra Durr ; Rita Guerreiro ; Dena Hernandez ; Alexis Brice ; Hreinn Stefánsson ; Kari Majamaa ; Thomas Gasser ; Peter Heutink ; Nick Wood ; Maria Martinez ; Andrew B. Singleton ; Michael A. Nalls ; John Hardy ; Michael J. Owen ; Michael C. O'Donovan ; Julie Williams ; Huw R. Morris ; Nigel M. WilliamsSource :
- JAMA neurology [ 2168-6157 ] ; 2013.
Descripteurs français
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer Disease (genetics), Databases, Factual (statistics & numerical data), Europe, Female, Gene Frequency, Genetic Predisposition to Disease (genetics), Genome-Wide Association Study, Genotype, Humans, In Vitro Techniques, Male, Middle Aged, Parkinson Disease (genetics), Polymorphism, Single Nucleotide (genetics), Risk Factors, United States.
- MESH :
- geographic : Europe, United States.
- genetics : Alzheimer Disease, Genetic Predisposition to Disease, Parkinson Disease, Polymorphism, Single Nucleotide.
- statistics & numerical data : Databases, Factual.
- Adult, Aged, Aged, 80 and over, Female, Gene Frequency, Genome-Wide Association Study, Genotype, Humans, In Vitro Techniques, Male, Middle Aged, Risk Factors.
Abstract
Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically distinct entities, there is a possibility of a pathological overlap, with some genome-wide association (GWA) studies suggesting that the 2 diseases represent a biological continuum. The application of GWA studies to idiopathic forms of AD and PD have identified a number of loci that contain genetic variants that increase the risk of these disorders.
DOI: 10.1001/jamaneurol.2013.448
PubMed: 23921447
Affiliations:
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Le document en format XML
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Bras</name></author><author><name sortKey="Bettella, Francesco" sort="Bettella, Francesco" uniqKey="Bettella F" first="Francesco" last="Bettella">Francesco Bettella</name></author><author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F" last="Keller">Margaux F. Keller</name></author><author><name sortKey="Nicolaou, Nayia" sort="Nicolaou, Nayia" uniqKey="Nicolaou N" first="Nayia" last="Nicolaou">Nayia Nicolaou</name></author><author><name sortKey="Sim N Sanchez, Javier" sort="Sim N Sanchez, Javier" uniqKey="Sim N Sanchez J" first="Javier" last="Sim N-Sánchez">Javier Sim N-Sánchez</name></author><author><name sortKey="Gibbs, J Raphael" sort="Gibbs, J Raphael" uniqKey="Gibbs J" first="J Raphael" last="Gibbs">J Raphael Gibbs</name></author><author><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name></author><author><name sortKey="Guerreiro, Rita" sort="Guerreiro, Rita" uniqKey="Guerreiro R" first="Rita" last="Guerreiro">Rita Guerreiro</name></author><author><name sortKey="Hernandez, Dena" sort="Hernandez, Dena" uniqKey="Hernandez D" first="Dena" last="Hernandez">Dena Hernandez</name></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefánsson">Hreinn Stefánsson</name></author><author><name sortKey="Majamaa, Kari" sort="Majamaa, Kari" uniqKey="Majamaa K" first="Kari" last="Majamaa">Kari Majamaa</name></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name></author><author><name sortKey="Wood, Nick" sort="Wood, Nick" uniqKey="Wood N" first="Nick" last="Wood">Nick Wood</name></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></author><author><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name></author><author><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C" last="O'Donovan">Michael C. O'Donovan</name></author><author><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name></author><author><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name></author><author><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel M" last="Williams">Nigel M. Williams</name></author></analytic><series><title level="j">JAMA neurology</title><idno type="eISSN">2168-6157</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (genetics)</term><term>Databases, Factual (statistics & numerical data)</term><term>Europe</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>In Vitro Techniques</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Risk Factors</term><term>United States</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Genetic Predisposition to Disease</term><term>Parkinson Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Gene Frequency</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>In Vitro Techniques</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite Alzheimer disease (AD) and Parkinson disease (PD) being clinically distinct entities, there is a possibility of a pathological overlap, with some genome-wide association (GWA) studies suggesting that the 2 diseases represent a biological continuum. The application of GWA studies to idiopathic forms of AD and PD have identified a number of loci that contain genetic variants that increase the risk of these disorders.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bettella, Francesco" sort="Bettella, Francesco" uniqKey="Bettella F" first="Francesco" last="Bettella">Francesco Bettella</name><name sortKey="Bras, Jose M" sort="Bras, Jose M" uniqKey="Bras J" first="Jose M" last="Bras">Jose M. Bras</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Durr">Alexandra Durr</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Gibbs, J Raphael" sort="Gibbs, J Raphael" uniqKey="Gibbs J" first="J Raphael" last="Gibbs">J Raphael Gibbs</name><name sortKey="Guerreiro, Rita" sort="Guerreiro, Rita" uniqKey="Guerreiro R" first="Rita" last="Guerreiro">Rita Guerreiro</name><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><name sortKey="Harold, Denise" sort="Harold, Denise" uniqKey="Harold D" first="Denise" last="Harold">Denise Harold</name><name sortKey="Hernandez, Dena" sort="Hernandez, Dena" uniqKey="Hernandez D" first="Dena" last="Hernandez">Dena Hernandez</name><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><name sortKey="Holmans, Peter" sort="Holmans, Peter" uniqKey="Holmans P" first="Peter" last="Holmans">Peter Holmans</name><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F" last="Keller">Margaux F. Keller</name><name sortKey="Majamaa, Kari" sort="Majamaa, Kari" uniqKey="Majamaa K" first="Kari" last="Majamaa">Kari Majamaa</name><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><name sortKey="Morris, Huw R" sort="Morris, Huw R" uniqKey="Morris H" first="Huw R" last="Morris">Huw R. Morris</name><name sortKey="Moskvina, Valentina" sort="Moskvina, Valentina" uniqKey="Moskvina V" first="Valentina" last="Moskvina">Valentina Moskvina</name><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A" last="Nalls">Michael A. Nalls</name><name sortKey="Nicolaou, Nayia" sort="Nicolaou, Nayia" uniqKey="Nicolaou N" first="Nayia" last="Nicolaou">Nayia Nicolaou</name><name sortKey="O Donovan, Michael C" sort="O Donovan, Michael C" uniqKey="O Donovan M" first="Michael C" last="O'Donovan">Michael C. O'Donovan</name><name sortKey="Owen, Michael J" sort="Owen, Michael J" uniqKey="Owen M" first="Michael J" last="Owen">Michael J. Owen</name><name sortKey="Russo, Giancarlo" sort="Russo, Giancarlo" uniqKey="Russo G" first="Giancarlo" last="Russo">Giancarlo Russo</name><name sortKey="Saad, Mohamed" sort="Saad, Mohamed" uniqKey="Saad M" first="Mohamed" last="Saad">Mohamed Saad</name><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><name sortKey="Sim N Sanchez, Javier" sort="Sim N Sanchez, Javier" uniqKey="Sim N Sanchez J" first="Javier" last="Sim N-Sánchez">Javier Sim N-Sánchez</name><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B" last="Singleton">Andrew B. Singleton</name><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefánsson">Hreinn Stefánsson</name><name sortKey="Vedernikov, Alexey" sort="Vedernikov, Alexey" uniqKey="Vedernikov A" first="Alexey" last="Vedernikov">Alexey Vedernikov</name><name sortKey="Williams, Julie" sort="Williams, Julie" uniqKey="Williams J" first="Julie" last="Williams">Julie Williams</name><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel M" last="Williams">Nigel M. Williams</name><name sortKey="Wood, Nick" sort="Wood, Nick" uniqKey="Wood N" first="Nick" last="Wood">Nick Wood</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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