ParkinsonFranceV1, Main, Exploration, bibRecord, 000D76

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease☆

Identifieur interne : 000D76 ( Main/Exploration ); précédent : 000D75; suivant : 000D77

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease☆

Auteurs : Rik Vandenberghe [Belgique] ; Katarzyna Adamczuk [Belgique] ; Patrick Dupont [Belgique] ; Koen Van Laere [Belgique] ; Gaël Chételat [France]

Source :

NeuroImage : Clinical [ 2213-1582 ] ; 2013.

RBID : PMC:3777773

Abstract

Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related β amyloidosis. Based on recent findings from cross-sectional and longitudinal imaging studies using different modalities, we will incorporate amyloid imaging into a multidimensional model of Alzheimer's disease. Aside from the critical role in improving clinical trial design for amyloid-lowering drugs, we will also propose a tentative algorithm for when it may be useful in a memory clinic environment. Gaps in our evidence-based knowledge of the added value of amyloid imaging in a clinical context will be identified and will need to be addressed by dedicated studies of clinical utility.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777773

DOI: 10.1016/j.nicl.2013.03.014
PubMed: 24179802
PubMed Central: 3777773

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related <italic>β</italic>
 amyloidosis. Based on recent findings from cross-sectional and longitudinal imaging studies using different modalities, we will incorporate amyloid imaging into a multidimensional model of Alzheimer's disease. Aside from the critical role in improving clinical trial design for amyloid-lowering drugs, we will also propose a tentative algorithm for when it may be useful in a memory clinic environment. Gaps in our evidence-based knowledge of the added value of amyloid imaging in a clinical context will be identified and will need to be addressed by dedicated studies of clinical utility.</p>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
</country>
<region><li>Basse-Normandie</li>
<li>Région Normandie</li>
</region>
<settlement><li>Caen</li>
</settlement>
<orgName><li>Université de Caen Basse-Normandie</li>
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</list>
<tree><country name="Belgique"><noRegion><name sortKey="Vandenberghe, Rik" sort="Vandenberghe, Rik" uniqKey="Vandenberghe R" first="Rik" last="Vandenberghe">Rik Vandenberghe</name>
</noRegion>
<name sortKey="Adamczuk, Katarzyna" sort="Adamczuk, Katarzyna" uniqKey="Adamczuk K" first="Katarzyna" last="Adamczuk">Katarzyna Adamczuk</name>
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<name sortKey="Dupont, Patrick" sort="Dupont, Patrick" uniqKey="Dupont P" first="Patrick" last="Dupont">Patrick Dupont</name>
<name sortKey="Dupont, Patrick" sort="Dupont, Patrick" uniqKey="Dupont P" first="Patrick" last="Dupont">Patrick Dupont</name>
<name sortKey="Laere, Koen Van" sort="Laere, Koen Van" uniqKey="Laere K" first="Koen Van" last="Laere">Koen Van Laere</name>
<name sortKey="Vandenberghe, Rik" sort="Vandenberghe, Rik" uniqKey="Vandenberghe R" first="Rik" last="Vandenberghe">Rik Vandenberghe</name>
<name sortKey="Vandenberghe, Rik" sort="Vandenberghe, Rik" uniqKey="Vandenberghe R" first="Rik" last="Vandenberghe">Rik Vandenberghe</name>
</country>
<country name="France"><region name="Région Normandie"><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name>
</region>
<name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name>
<name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name>
<name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease☆

Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease☆

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	La maladie de Parkinson en France (serveur d'exploration)
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