Supplementary and primary sensory motor area activity in Parkinson's disease : regional cerebral blood flow changes during finger movements and effects of apomorphine
Identifieur interne : 004E33 ( Main/Curation ); précédent : 004E32; suivant : 004E34Supplementary and primary sensory motor area activity in Parkinson's disease : regional cerebral blood flow changes during finger movements and effects of apomorphine
Auteurs : O. Rascol [France] ; U. Sabatini ; F. Chollet ; P. Celsis ; J.-L. Montastruc ; J.-P. Marc-Vergnes ; A. RascolSource :
- Archives of neurology : (Chicago) [ 0003-9942 ] ; 1992.
Descripteurs français
- Pascal (Inist)
- Parkinson maladie, Maladie dégénérative, Akinésie, Tomoscintigraphie, Exploration radioisotopique, Photon, Débit sanguin régional, Encéphale, Hémodynamique, Mouvement corporel, Doigt, Membre supérieur, Noyau gris central, Cortex moteur, Apomorphine, Système nerveux pathologie, Epreuve pharmacologique, Stimulant dopaminergique.
English descriptors
- KwdEn :
- Aged, Akinesia, Apomorphine (pharmacology), Basal ganglion, Body movement, Brain (vertebrata), Brain Mapping, Cerebrovascular Circulation (drug effects), Degenerative disease, Dopamine agonist, Female, Finger, Fingers (physiology), Hemodynamics, Humans, Male, Middle Aged, Motor Cortex (diagnostic imaging), Motor Cortex (physiopathology), Motor cortex, Movement, Nervous system diseases, Parkinson Disease (diagnostic imaging), Parkinson Disease (physiopathology), Parkinson disease, Pharmacologic test, Photon, Positron emission tomography, Radionuclide study, Regional blood flow, Tomography, Emission-Computed, Single-Photon, Upper limb.
- MESH :
- chemical , pharmacology : Apomorphine.
- diagnostic imaging : Motor Cortex, Parkinson Disease.
- drug effects : Cerebrovascular Circulation.
- physiology : Fingers.
- physiopathology : Motor Cortex, Parkinson Disease.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged, Movement, Tomography, Emission-Computed, Single-Photon.
Abstract
We have measured with single-photon emission tomography the regional cerebral blood flow changes that occurred in the supplementary motor areas and in the primary sensory motor areas during sequential finger-to-thumb opposition movements of the right hand in seven akinetic patients with Parkinson's disease and in nine normal volunteers. Parkinsonian patients were studied before («off» condition) and after a subcutaneous injection of apomorphine hydrochloride which was able to switch them «on» (on condition)
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Pascal:92-0210001Le document en format XML
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Rascol</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National inst. health medical res., fac. medicine, medical clin. pharmacology</s1><s2>Toulouse</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P." last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J.-L." last="Montastruc">J.-L. Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J.-P." last="Marc-Vergnes">J.-P. Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A." last="Rascol">A. Rascol</name></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="1992">1992</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Akinesia</term><term>Apomorphine (pharmacology)</term><term>Basal ganglion</term><term>Body movement</term><term>Brain (vertebrata)</term><term>Brain Mapping</term><term>Cerebrovascular Circulation (drug effects)</term><term>Degenerative disease</term><term>Dopamine agonist</term><term>Female</term><term>Finger</term><term>Fingers (physiology)</term><term>Hemodynamics</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (diagnostic imaging)</term><term>Motor Cortex (physiopathology)</term><term>Motor cortex</term><term>Movement</term><term>Nervous system diseases</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Pharmacologic test</term><term>Photon</term><term>Positron emission tomography</term><term>Radionuclide study</term><term>Regional blood flow</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Upper limb</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fingers</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Maladie dégénérative</term><term>Akinésie</term><term>Tomoscintigraphie</term><term>Exploration radioisotopique</term><term>Photon</term><term>Débit sanguin régional</term><term>Encéphale</term><term>Hémodynamique</term><term>Mouvement corporel</term><term>Doigt</term><term>Membre supérieur</term><term>Noyau gris central</term><term>Cortex moteur</term><term>Apomorphine</term><term>Système nerveux pathologie</term><term>Epreuve pharmacologique</term><term>Stimulant dopaminergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have measured with single-photon emission tomography the regional cerebral blood flow changes that occurred in the supplementary motor areas and in the primary sensory motor areas during sequential finger-to-thumb opposition movements of the right hand in seven akinetic patients with Parkinson's disease and in nine normal volunteers. Parkinsonian patients were studied before («off» condition) and after a subcutaneous injection of apomorphine hydrochloride which was able to switch them «on» (on condition)</div></front></TEI><double idat="0003-9942:1992:Rascol O:supplementary:and:primary"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Supplementary and primary sensory motor area activity in Parkinson's disease : regional cerebral blood flow changes during finger movements and effects of apomorphine</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National inst. health medical res., fac. medicine, medical clin. pharmacology</s1><s2>Toulouse</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P." last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J.-L." last="Montastruc">J.-L. Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J.-P." last="Marc-Vergnes">J.-P. Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A." last="Rascol">A. Rascol</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">92-0210001</idno><date when="1992">1992</date><idno type="stanalyst">PASCAL 92-0210001 INIST</idno><idno type="RBID">Pascal:92-0210001</idno><idno type="wicri:Area/PascalFrancis/Corpus">001B48</idno><idno type="wicri:Area/PascalFrancis/Curation">001503</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001948</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001948</idno><idno type="wicri:doubleKey">0003-9942:1992:Rascol O:supplementary:and:primary</idno><idno type="wicri:Area/Main/Merge">005871</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Supplementary and primary sensory motor area activity in Parkinson's disease : regional cerebral blood flow changes during finger movements and effects of apomorphine</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O." last="Rascol">O. Rascol</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>National inst. health medical res., fac. medicine, medical clin. pharmacology</s1><s2>Toulouse</s2><s3>FRA</s3></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U." last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F." last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P." last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J.-L." last="Montastruc">J.-L. Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J.-P." last="Marc-Vergnes">J.-P. Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A." last="Rascol">A. Rascol</name></author></analytic><series><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno><imprint><date when="1992">1992</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title><title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title><idno type="ISSN">0003-9942</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Akinesia</term><term>Basal ganglion</term><term>Body movement</term><term>Brain (vertebrata)</term><term>Degenerative disease</term><term>Dopamine agonist</term><term>Finger</term><term>Hemodynamics</term><term>Motor cortex</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Pharmacologic test</term><term>Photon</term><term>Positron emission tomography</term><term>Radionuclide study</term><term>Regional blood flow</term><term>Upper limb</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Maladie dégénérative</term><term>Akinésie</term><term>Tomoscintigraphie</term><term>Exploration radioisotopique</term><term>Photon</term><term>Débit sanguin régional</term><term>Encéphale</term><term>Hémodynamique</term><term>Mouvement corporel</term><term>Doigt</term><term>Membre supérieur</term><term>Noyau gris central</term><term>Cortex moteur</term><term>Apomorphine</term><term>Système nerveux pathologie</term><term>Epreuve pharmacologique</term><term>Stimulant dopaminergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have measured with single-photon emission tomography the regional cerebral blood flow changes that occurred in the supplementary motor areas and in the primary sensory motor areas during sequential finger-to-thumb opposition movements of the right hand in seven akinetic patients with Parkinson's disease and in nine normal volunteers. Parkinsonian patients were studied before («off» condition) and after a subcutaneous injection of apomorphine hydrochloride which was able to switch them «on» (on condition)</div></front></TEI></INIST><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><affiliation wicri:level="3"><nlm:affiliation>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1736846</idno><idno type="pmid">1736846</idno><idno type="wicri:Area/PubMed/Corpus">001768</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001768</idno><idno type="wicri:Area/PubMed/Curation">001727</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001727</idno><idno type="wicri:Area/PubMed/Checkpoint">001727</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001727</idno><idno type="wicri:Area/Ncbi/Merge">000713</idno><idno type="wicri:Area/Ncbi/Curation">000713</idno><idno type="wicri:Area/Ncbi/Checkpoint">000713</idno><idno type="wicri:doubleKey">0003-9942:1992:Rascol O:supplementary:and:primary</idno><idno type="wicri:Area/Main/Merge">005693</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.</title><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><affiliation wicri:level="3"><nlm:affiliation>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Medical and Clinical Pharmacology Service, Faculty of Medicine, Purpan University Hospital Center, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Sabatini, U" sort="Sabatini, U" uniqKey="Sabatini U" first="U" last="Sabatini">U. Sabatini</name></author><author><name sortKey="Chollet, F" sort="Chollet, F" uniqKey="Chollet F" first="F" last="Chollet">F. Chollet</name></author><author><name sortKey="Celsis, P" sort="Celsis, P" uniqKey="Celsis P" first="P" last="Celsis">P. Celsis</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author><author><name sortKey="Marc Vergnes, J P" sort="Marc Vergnes, J P" uniqKey="Marc Vergnes J" first="J P" last="Marc-Vergnes">J P Marc-Vergnes</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="ISSN">0003-9942</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apomorphine (pharmacology)</term><term>Brain Mapping</term><term>Cerebrovascular Circulation (drug effects)</term><term>Female</term><term>Fingers (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (diagnostic imaging)</term><term>Motor Cortex (physiopathology)</term><term>Movement</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (physiopathology)</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fingers</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have measured with single-photon emission tomography the regional cerebral blood flow changes that occurred in the supplementary motor areas and in the primary sensory motor areas during sequential finger-to-thumb opposition movements of the right hand in seven akinetic patients with Parkinson's disease and in nine normal volunteers. Parkinsonian patients were studied before ("off" condition) and after a subcutaneous injection of apomorphine hydrochloride which was able to switch them "on" (on condition). In normal volunteers and parkinsonian patients in the on condition, regional cerebral blood flow significantly increased in the supplementary motor areas and in the contralateral primary sensory motor cortex but not in the ipsilateral primary sensory motor cortex. On the contrary, no significant regional cerebral blood flow change was observed in these areas in parkinsonian patients in the off condition. These results support the hypothesis that a functional cortical motor area deafferentation is involved in the pathophysiological makeup of akinesia and that this abnormality is reversed by dopaminergic drugs.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Supplementary and primary sensory motor area activity in Parkinson's disease : regional cerebral blood flow changes during finger movements and effects of apomorphine
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